Influence of Distinct Radiotherapy Techniques to Induce Second Cancer Risks in Left Breast Cancer

Abstract

Influence of distinct radiotherapy techniques to induce second cancer risks in left breast cancer. Material and methods: Ten female patients with intact left breast cancer. Two treatment plans for each patient: 1) two tangential beams 3D-Conformal radiotherapy, 2) intensity-modulated radiotherapy (IMRT) plan. Estimation of second cancer risk from Organ equivalent dose models (OEDs) in three dose-response model for organs at risk in left breast cases. Results: The P-value for OED models in 3D-IMRT for left lung, both lung, heart, right lung, right breast, thyroid, liver and spinal cord in linear dose model was 0.016, 0.005, 0.019, 3.95E−06, 5.79E−07, 0.003, 1.78E−10 and 0.000206475 respectively, for linear exponential dose model 0.0577, 0.024, 0.031, 3.40E−06, 3.28E−07, 0.003, 2.01E−10 and 0.000120072 respectively and in plateau dose model 0.088, 0.042, 0.039, 3.18E−06, 2.53E−07, 0.003, 2.27E−10 and 9.00535E−05 respectively. Conclusion: organ equivalent dose models for organs at risk increasing in IMRT than tangential beams.

Incidence risk assessment of secondary cancer due to radiotherapy of women with rectal cancer using BEIR VII, EPA, and ICRP models

“…It was observed that the risk using the ICRP model was significantly higher when comparing BEIR VII, and EPA models as shown the data in Figure 4 which show three models of ERR and EAR values This is consistent with the study by Amaoui et al [ 27 ] on the evaluation SCRs in breast cancer using the EAR and ERR from the ICRP models. They reported that the results are much higher (by around 19 times) than those calculated by Elgendy et al [ 28 ] on the estimation of SCRs in breast cancer. A limitation of the current study was that the results were based on 3D-CRT.…”

Collapsed cone superposition algorithm validation for chest wall tangential fields using virtual wedge filters

“…Researches have demonstrated that using VW to treat breast cancer in comparison to intensity-modulated radiation therapy can reduce the risk of secondary cancer, OAR, and body radiation exposure. [ 12 13 ] Some studies have evaluated the dose calculation accuracy of various algorithms in the wedged field technique. Venselaar et al .…”