Influence of disease burden, public perception, and other factors on new vaccine development, implementation, and continued use

Levine, Myron M.; Levine, Orin S.

doi:10.1016/s0140-6736(97)03253-4

Cited by 53 publications

(30 citation statements)

References 35 publications

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“…T yphoid fever remains highly prevalent in developing countries, with an estimated 16 million new cases annually and 600,000 deaths (1,2). The appearance of antibiotic-resistant Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, has added new urgency for the development of a typhoid vaccine that is well tolerated, highly immunogenic, and protective (1,2).…”

mentioning

confidence: 99%

“…The appearance of antibiotic-resistant Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, has added new urgency for the development of a typhoid vaccine that is well tolerated, highly immunogenic, and protective (1,2). The only licensed attenuated live oral typhoid vaccine, S. Typhi strain Ty21a, is well tolerated and immunogenic, but requires three or four spaced doses of 2-6 ϫ 10 9 CFU each given every other day, an important practical shortcoming (1).…”

mentioning

confidence: 99%

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Concomitant Induction of CD4+ and CD8+ T Cell Responses in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain CVD 908-htrA

Salerno-Gonçalves

Wyant

Pasetti

et al. 2003

The Journal of Immunology

138

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Type 1 cell-mediated immunity might play an important role in protection from typhoid fever. We evaluated whether immunization with Salmonella enterica serovar Typhi (S. Typhi) strain CVD 908-htrA (a ΔaroC ΔaroD ΔhtrA mutant), a leading live oral typhoid vaccine candidate, elicits specific CD4+ and CD8+ S. Typhi immune responses. Potent CTL responses and IFN-γ secretion by CD8+ T cells were detected following immunization with CVD 908-htrA in high (4.5 × 108 CFU) and low (5 × 107 CFU) dosages. S. Typhi-specific CTL were observed in six of eight vaccinees (four high and two low dose) after immunization. Mean increases in the frequency of IFN-γ spot-forming cells (SFC) in the presence of S. Typhi-infected targets were 221 ± 41 SFC/106 PBMC and 233 ± 87 SFC/106 PBMC, in the high and low dose groups, respectively. Strong CD4+ T cell responses were also observed. Increases in the IFN-γ production to soluble S. Typhi flagella (STF) occurred in 82 and 38% of the volunteers who received the high and low doses, respectively. Robust correlations were observed between volunteers that responded with IFN-γ SFC to stimulation with S. Typhi-infected cells and IFN-γ released in response to stimulation with STF Ags (r = 0.822, p < 0.001) and between CTL and IFN-γ production to STF (r = 0.818, p = 0.013). These data demonstrating the concomitant induction of both CD4- and CD8-mediated CMI are consistent with a significant role for type 1 immunity in controlling typhoid infection and support the continuing evaluation of CVD 908-htrA as a typhoid vaccine candidate.

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confidence: 99%

mentioning

confidence: 99%

Concomitant Induction of CD4+ and CD8+ T Cell Responses in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain CVD 908-htrA

Salerno-Gonçalves

Wyant

Pasetti

et al. 2003

The Journal of Immunology

138

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“…Worldwide, typhoid fever affects ϳ16 million individuals annually with 600,000 deaths (3). In Asia and northeast Africa, the appearance of S. typhi showing resistance to many antibiotics has become an important public-health problem (4). Therefore, an improved prophylactic vaccine to prevent typhoid fever is urgently needed.…”

mentioning

confidence: 99%

“…Results from studies in typhoid patients and vaccine trials with attenuated S. typhi indicate that Abs appear to be involved in protection against S. typhi (2, 6, 7). However, the role of cell-mediated immunity (CMI) 4 in protection from S. typhi infection remains unclear. There is considerable evidence that host resistance to many intracellular bacteria such as Listeria monocytogenes (8,9), and Mycobacteria (10,11) is strongly influenced by CMI responses.…”

mentioning

confidence: 99%

Characterization of CD8+ Effector T Cell Responses in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain Ty21a Typhoid Vaccine

Salerno-Gonçalves

Pasetti

Sztein

2002

The Journal of Immunology

129

167

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Salmonella enterica serovar Typhi (S. typhi) strain Ty21a remains the only licensed attenuated typhoid vaccine. Despite years of research, the identity of the protective immunological mechanisms elicited by immunization with the Ty21a typhoid vaccine remains elusive. The present study was designed to characterize effector T cell responses in volunteers immunized with S. typhi strain Ty21a typhoid vaccine. We determined whether immunization with Ty21a induced specific CTL able to lyse S. typhi-infected cells and secrete IFN-γ, a key effector molecule against intracellular pathogens. We measured the functional activity of these CTL by a 51Cr-release assay using 8-day restimulated PBMC from Ty21a vaccinees as effector cells and S. Typhi-infected autologous PHA-activated PBMC as target cells. Most vaccinees exhibited consistently increased CD8-mediated lysis of targets by postimmunization PBMC when compared with preimmunization levels. We also developed an IFN-γ ELISPOT assay to quantify the frequency of IFN-γ spot-forming cells (SFC) in PBMC from Ty21a vaccinees using an ex vivo system. Significant increases in the frequency of IFN-γ SFC following immunization (mean ± SD, 393 ± 172; range 185–548 SFC/106 PBMC; p = 0.010), as compared with preimmunization levels, were observed. IFN-γ was secreted predominantly by CD8+ T cells. A strong correlation was recorded between the cytolytic activity of CTL lines and the frequency of IFN-γ SFC (r2 = 0.910, p < 0.001). In conclusion, this work constitutes the first evidence that immunization of volunteers with Ty21a elicits specific CD8+ CTL and provides an estimate of the frequency of CD8+ IFN-γ-secreting cells induced by vaccination.

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“…Ces données et leur modélisation constituent un préalable indispensable à la mise en place d'une campagne de vaccination, permettant d'en définir les objectifs [16][17][18][19]. En effet, un manque de clarté sur les objectifs de santé publique poursuivis peut mener à l'échec d'une campagne de vaccination.…”

Section: Disposer De Données De Surveillance éPidémiologiqueunclassified

L’évaluation du rapport risque/ bénéfice des stratégies de vaccination

Hanslik

Boëlle

2007

Med Sci (Paris)

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Influence of disease burden, public perception, and other factors on new vaccine development, implementation, and continued use

Cited by 53 publications

References 35 publications

Concomitant Induction of CD4+ and CD8+ T Cell Responses in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain CVD 908-htrA

Concomitant Induction of CD4+ and CD8+ T Cell Responses in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain CVD 908-htrA

Characterization of CD8+ Effector T Cell Responses in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain Ty21a Typhoid Vaccine

L’évaluation du rapport risque/ bénéfice des stratégies de vaccination

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