Materials and methods. A study was conducted at the Department of Orthopedic Dentistry and Orthodontics of the Ryazan State Medical University, in which one patient (A.) after tooth extraction underwent orthopedic rehabilitation using the method of immediate prosthetics, in the second patient (B.) healing after extraction proceeded naturally. Both patients underwent dental implantation 4 months later. After tooth extraction and implantation, both patients underwent a complex of diagnostic observations on days 7, 20, 30 using objective, instrumental and laboratory control of inflammation using the Schiller-Pisarev test, laser doppler flowmetry, and assessment of the level of pro-inflammatory cytokines IL-6, C-reactive protein, TNF-.
Results. After the extraction of teeth on the 30th day, the indicators of the clinical picture in both patients indicated a complete subsidence of inflammation and stabilization of repair. In patient A., the IL-6 values were 1.36 pg/ml, in patient B 1.75 pg/ml, the level of CRP in patient A. was 0.68 mg/l, in patient B. 0.88 mg/l . TNF- in patient A. was 17.8 pg/ml, in patient B. 21.3 pg/ml. Indicators of LDF in patient A. 18.47 conventional units, in patient B. the microcirculation parameter was equal to 11.46 conventional units. After implantation on the 30th day, the indicators were as follows: in patient A., the IL-6 values were 1.39 pg/ml, in patient B. 1.78 pg/ml, the level of CRP in patient A. was 0.74 mg/l, in patient B. 0.92 mg/ml l. TNF- in patient A. was 18.9 pg/ml, in patient B. - 20.2 pg/ml. The LDF values in patient A were 20.35 units, in patient B the microcirculation parameter was 19.62 units.
Conclusion. A comprehensive analysis of inflammation is effective due to its high information content and the ability to identify possible complications.