Influence of dipyridamole stress echocardiography on galectin-3, amino-terminal B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T

Lippi, Giuseppe; Salvagno, Gian Luca; Robuschi, Fiorenza; Scioscioli, Francesco; Ruffini, Livia; Cervellin, Gianfranco

doi:10.1080/ac.69.4.3036653

Cited by 3 publications

(3 citation statements)

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“…48 Our findings in the DIP group are consistent with previously published studies showing no hsTnT release following a dipyridamole challenge, which is probably due to the absence of adrenergic stimulation and resulting increased wall stress observed during the ExSE and DSE. 15,16,49,50…”

Section: Discussionmentioning

confidence: 99%

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors–single center study

et al. 2022

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Objectives In stress echocardiography (SE), dipyridamole (DIP) and dynamic stress (ExSE) are reported as being safer than dobutamine stress echocardiography (DSE). We investigated whether these commonly used stressors cause myocardial injury, measured by high sensitivity troponin T (hsTnT). Methods One hundred and thirty five patients (DSE n = 46, ExsE n = 46, DIP n = 43) with negative result of SE were studied. The exclusion criteria were known ischaemic heart disease (IHD), baseline wall motion abnormalities, left ventricle systolic dysfunction/regional wall motion abnormalities, septum/posterior wall ≥13 mm, diabetes/pre‐diabetes, baseline hsTnT level ≥14 ng/L, baseline blood pressure ≥160/100 mmHg, peak pulmonary pressure ≥45mmHg, eGFR <1ml/s/1.73m2, more than mild to moderate valvular disease and dobutamine side effects. HsTnT was measured before and 180 minutes after the test. Results All patients had low pre‐test probabilities of having obstructive IHD. HsTnT increased in DSE, less so in ExSE, and was unchanged in the DIP group (∆hsTnT 9.4 [1.5–58.6], 1.1 [‐0.9–15.7], ‐0.1 [‐1.4–2.1] ng/L, respectively, p<0.001). In DSE, the ∆hsTnT was associated with peak dobutamine dose (r = 0.30, p = 0.045), test length (r = 0.43, p = 0.003) and atropine use (p<0.001). In ExSE, the hsTnT increase was more likely in females (p = 0.012) and the elderly (>65 years) (r = 0.32, p = 0.03); no association was found between atropine use (p = 0.786) or test length and ∆hsTnT (r = 0.10, p = 0.530). Conclusions DSE is associated with myocardial injury in patients with negative SE, no injury was observed in DIP and only mild case in ExSE. Whether myocardial injury is causative of the higher reported adverse event rates in DSE remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors–single center study

et al. 2022

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“…GAL-3 is a marker of tissue fibrosis, which is a hallmark of cardiac remodeling and heart failure. This can be reliably measured in the blood and studies have shown its prognostic value in heart failure [118]. GAL-3 is a 31-kDa member of family of lectins that bind beta-galactosides by either N-linked or O-linked glycosylation through their carbohydrate recognition domain (CRD) [119].…”

Section: Galectin-3 (Gal-3)mentioning

confidence: 99%

Cardiac biomarkers in dialysis

2017

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Cardiovascular disease is the major cause of death, accounting for approximately 40 percent of all-cause mortality in patients receiving either hemodialysis or peritoneal dialysis. Cardiovascular risk stratification is an important aspect of managing dialysis patients as it enables early identification of high-risk patients, so therapeutic interventions can be optimized to lower cardiovascular morbidity and mortality. Biomarkers can detect early stages of cardiac injury so timely intervention can be provided. The B-type natriuretic peptides (Brain Natriuretic peptide [BNP] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]) and troponins have been shown to predict mortality in dialysis patients. Suppression of tumorigenicity 2 (ST2) and galectin-3 are new emerging biomarkers in the field of heart failure in both the general and dialysis populations. This article aims to discuss the current evidence regarding cardiac biomarker use to diagnose myocardial injury and monitor the risk of major adverse cardiovascular events in patients undergoing dialysis.

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“…This biomarker can reliably be measured in the circulation, and several recent studies have shown its prognostic value in acute and chronic HF, and its potential utility in the general population (10). GAL-3 [also occasionally referred as Mac-2 or carbohydrate-binding protein (CBP)-35] is a 31-kDa member of a growing family of lectins that bind β-galactosides by either N-linked or O-linked glycosylation through their carbohydrate recognition domain (CRD) (11).…”

Section: Gal-3mentioning

confidence: 99%

Prognostic biomarkers in acute coronary syndrome

Salvagno¹,

Pavan²

2016

Ann. Transl. Med.

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The acute coronary syndrome (ACS) is a leading cause of death around the globe. Beside a still high mortality rate, additional complications of ACS include arrhythmias, left ventricular mural thrombus, cardiac fibrosis, heart failure (HF), cardiogenic shock, mitral valve dysfunction, aneurysms, up to cardiac rupture. Despite many prognostic tools have been developed over the past decades, efforts are still ongoing to identify reliable and predictive biomarkers, which may help predict the prognosis of these patients and especially the risk of HF. Recent evidence suggests that the value of a discrete number of biomarkers of myocardial fibrosis, namely the soluble form of suppression of tumorigenicity 2 (sST2) and galectin-3 (GAL-3), may be predictive of HF and death in patients with ACS. Interestingly, the already promising predictive value of these biomarkers when measured alone was shown to be consistently magnified when combined with other and well-established cardiac biomarkers such natriuretic peptides and cardiac troponins. This article is hence aimed to review the current knowledge about cardiac biomarkers of fibrosis and adverse remodeling.

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Influence of dipyridamole stress echocardiography on galectin-3, amino-terminal B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T

Cited by 3 publications

References 0 publications

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors–single center study

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors–single center study

Cardiac biomarkers in dialysis

Prognostic biomarkers in acute coronary syndrome

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