Influence of Different Biological Environments on Serotonin (5‐HT) Electrochemical Behavior at Gold Screen Printed Electrodes

Abstract

Serotonin is a key neurotransmitter, present in the brain, blood and gastrointestinal tract. Due to the interest in measuring this important biogenic amine in these various environments, electrochemical recordings were carried out in PBS buffer, 0.5 % w/v mucin and 5 % w/v albumin on Screen Printed Gold Electrodes (SPAuEs) bare and modified with gold nanoparticles (AuNps), for better understanding the influence of the matrix on the stability of recordings The results suggest that the proteins resulted protective against electrode fouling, compared to PBS buffer, which enhanced the rate of such a fouling.

Three-dimensional mesoporous silica networks with improved diffusion and interference-abating properties for electrochemical sensing

“…Our samples were tested for the determination of dopamine, an important neurotransmitter widely studied in the field of neurodegenerative diseases, also in the presence of mucin as interferent species. Mucin is a high molecular weight glycoprotein that is a component of mucus and as a result, can be found in a variety of bodily fluids; it is easily adsorbed on electrode surfaces, giving rise to biofouling effects [76,77].…”