Influence of dietary vitamin E on prostaglandin biosynthesis in rat blood

Hope, William C.; Dalton, Colin; Machlin, L. J.; Filipski, R.; Vane, Floie M.

doi:10.1016/s0090-6980(75)80002-5

Cited by 79 publications

(15 citation statements)

References 16 publications

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“…Vitamin E should act by reducing the inflammatory process triggered by peritoneal trauma, because it inhibits cyclooxygenase-2 (COX-2) 9,11 and endogenous conversion of arachidonic acid to PGE 2 and PGF 2␣ . 12,13 Even more interestingly, its antioxidant function inhibits the oxidation started and mediated by free radicals, [14][15][16] which seem to play a key role in the inflammatory process related to the adhesion formation cascade, 17,18 and also have a deleterious effect on the mesothelial cells of the peritoneum.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Peritoneal Adhesions by Intraperitoneal Administration of Vitamin E: An Experimental Study in Rats

Portilla

Ynfante

Bejarano

et al. 2004

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Prevention of Peritoneal Adhesions by Intraperitoneal Administration of Vitamin E: An Experimental Study in Rats

Portilla

Ynfante

Bejarano

et al. 2004

Diseases of the Colon &Amp; Rectum

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“…Tocopherols are powerful in vivo antioxidants which are intimately associated with lipids of cell membranes and are postulated to exert wide-ranging effects on aging, cancer, arthritis, platelet aggregation, and prostaglandin synthesis (1,2). Natural plant tocopherols include alpha (αT), beta (βT), gamma (γT), and delta (δT) forms, but αT is widely believed to be the most biologically efficacious form of vitamin E in animals.…”

mentioning

confidence: 99%

Distribution of α‐and γ‐tocopherols in Atlantic salmon (Salmo salar) tissues

Parazo

Lall

Castell

et al. 1998

Lipids

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Groups of Atlantic salmon parr (mean initial weight 9.5 g) were fed three diets, the first containing no tocopherol supplement, the others supplemented with either all-rac-alpha-tocopherol (A-T) or RRR-gamma-tocopherol (G-T). Tocopherol concentrations in the liver, serum, testes, kidney, brain, gill, muscle, and perivisceral fat were measured after 36 wk. Despite a higher dietary intake of G-T, compared to A-T, deposition of gamma-tocopherol (gammaT) was less efficient than of alpha-tocopherol (alphaT) in most tissues except in the perivisceral fat, an adipose tissue. In fish fed the G-T diet, the gammaT/alphaT ratio was highest in the perivisceral fat and lowest in the liver, indicating that the liver is the most discriminatory organ for retaining alphaT as compared to gammaT, and the perivisceral fat is more suitable for the storage of gammaT. A negative correlation (P < 0.01) was observed between the gammaT/alphaT ratio and the corresponding tissue phospholipid content, suggesting that gammaT is less efficiently deposited compared to alphaT in the phospholipid-rich membranes which are presumed to be the functional site for lipid antioxidants in vivo. During restricted intake of alphaT, the liver and muscle exhibited the greatest reduction of this tocopherol among the tissues analyzed. The presence of minimal alphaT in the muscle from fish fed the tocopherol-unsupplemented diet led to greater susceptibility to lipid peroxidation after frozen storage than was the case for muscle containing higher concentrations of either alphaT or gammaT. However, both alphaT and gammaT were effective stabilizers of salmon muscle lipids during frozen storage.

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“…12 Favorable results with this therapy have been attributed to effects of vitamin E on platelet function. 11 Platelet hyperaggregability and increased malonyldialdehyde production have been demonstrated in vitamin E-deficient children, with complete reversal by supplemental dietary vitamin E. 13 Supplementation with dietary vitamin E has been shown to inhibit platelet aggregation, 1415 PGE 2 and PGF 2u synthesis, 16 and TxA 2 synthesis. 1718 We have recently reported that platelets from streptozotocin-diabetic rats, when compared with platelets from nondiabetic controls, contain decreased vitamin E content.…”

mentioning

confidence: 99%

Interrelation of Platelet Vitamin E and Thromboxane Synthesis in Type I Diabetes Mellitus

et al. 1984

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Platelet vitamin E content and thromboxane A2 (TxA2) synthesis have been investigated in type I diabetic subjects and age- and sex-matched controls. Platelets, but not plasma, from diabetic subjects contained significantly lower vitamin E levels and synthesized significantly greater amounts of TxA2 when challenged with collagen or thrombin than platelets from control subjects. Conversion of exogenously added arachidonic acid to TxA2 was unaltered between platelets from control and diabetic groups. Platelet vitamin E content from control and diabetic groups combined exhibited a significant negative linear correlation with collagen- and thrombin-induced TxA2 production. These data suggest that low platelet vitamin E levels could be a contributing factor to the increased thromboxane synthesis demonstrated by platelets from the above type I diabetic subjects.

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Influence of dietary vitamin E on prostaglandin biosynthesis in rat blood

Cited by 79 publications

References 16 publications

Prevention of Peritoneal Adhesions by Intraperitoneal Administration of Vitamin E: An Experimental Study in Rats

Prevention of Peritoneal Adhesions by Intraperitoneal Administration of Vitamin E: An Experimental Study in Rats

Distribution of α‐and γ‐tocopherols in Atlantic salmon (Salmo salar) tissues

Interrelation of Platelet Vitamin E and Thromboxane Synthesis in Type I Diabetes Mellitus

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