Influence of dietary unsaturated and saturated fat on the plasma lipoproteins of mongolian gerbils

Nicolosi, Robert J.; Marlett, Judith A.; Morello, Antonio; Flanagan, Susan; Hegsted, D. M.

doi:10.1016/0021-9150(81)90052-6

Cited by 29 publications

(15 citation statements)

References 48 publications

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“…In the present study, the gerbils' serum cholesterol levels were lowered by SO relative to BT after 11 days, regardless of the cholesterol content of the diets. This lowering effect of serum cholesterol by'a polyunsaturated fat relative to a saturated fat agrees with the reports of Mercer and Holub (8), Hegsted and Gallagher (10) and Nicolosi et al (11). The sensitivity of the response is in contrast to that seen in the rat and indicates the greater usefulness of the gerbil as an animal model.…”

Section: Discussionsupporting

confidence: 91%

The effect of dietary lipid on the lipoprotein status of the mongolian gerbil

Leach

Holub

1984

Lipids

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The Mongolian gerbil, Meriones unguiculatus, may be a suitable animal model for the investigation of dietary lipid effects on cholesterol metabolism. The effects of dietary cholesterol, and its possible interaction with the type of dietary fat, on the lipoprotein status of this animal have not been examined previously. In the present research, the effects of adding 0.5% cholesterol to diets high in saturated (19.5% beef tallow: 0.5% safflower oil) or polyunsaturated (20% safflower oil) fats on the lipoprotein status of the gerbil were determined after 11 and 22 days of feeding. Lipoproteins (VLDL, LDL and HDL) were separated by sequential ultracentrifugation. Their cholesterol, phospholipid and protein concentrations were determined colorimetrically. In the absence of 0.5% cholesterol, safflower oil lowered the concentration (mg/100 ml) of cholesterol in each of the VLDL, LDL and HDL relative to beef tallow (BT) without greatly influencing the cholesterol distribution amongst them. The HDL carried the majority of the serum cholesterol and the VLDL transported the smallest amount. However, inclusion of 0.5% dietary cholesterol resulted in a redistribution of cholesterol amongst the lipoproteins so that the VLDL and LDL became the major and the HDL the minor carriers. Dietary cholesterol also brought about a rise in the VLDL and LDL concentrations (mg/100 ml) of cholesterol, phospholipid and protein and altered the VLDL and LDL compositions. No such changes were observed in the HDL, indicating that the HDL are relatively resistant to any of the possible effects of cholesterol feeding measured in this experiment. The specific mechanisms responsible for the changes observed in the lipoprotein status of the gerbil remain to be elucidated.

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Section: Discussionsupporting

confidence: 91%

The effect of dietary lipid on the lipoprotein status of the mongolian gerbil

Leach

Holub

1984

Lipids

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“…Saturated fatty acids increase the blood cholesterol level (Nicolosi et al, 1981) and dietary cholesterol, even at low concentrations, induce hypercholesterolemia (Temmerman et al, 1988). Thus, gerbils react more readily than e.g.…”

Section: El;'fects On Plasma and Liver Lipids In Gerbils And Ratsmentioning

confidence: 99%

Analysis, Heat Stability and Physiological Effects of Saponins from Oats

Önning

Asp

1996

Advances in Experimental Medicine and Biology

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“…Others include genetically modified mice (Getz & Reardon, 2006), rats (Herrera & Ruiz-Opazo, 2005), monkeys (Ross & Harker, 1976), pigs (Koskinas et al, 2010), guinea pigs (Fernandez & Volek, 2006), hamsters (Russell & Proctor, 2006) and gerbils (Nicolosi et al, 1981). Rabbits have certain advantages that allow them to remain a useful model.…”

Section: Discussionmentioning

confidence: 99%

Optimization of a Low Magnesium, Cholesterol-Containing Diet for the Development of Atherosclerosis in Rabbits

Smith¹,

King²,

Miller³

et al. 2013

JFR

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The cholesterol-fed rabbit is useful for atherosclerosis research. We describe development of a low-magnesium (Mg) cholesterol-containing diet to accelerate atherosclerosis in this model. Male New Zealand White rabbits were fed either chow or one of four atherogenic diets: 1% cholesterol 10% fat 0.11% Mg, 1% cholesterol 10% fat 0.40% Mg, 2% cholesterol 20% fat 0.11% Mg, or 2% cholesterol 20% fat 0.40% Mg. While feed intake decreased in cholesterol-fed rabbits, they were able to maintain their body weights. Rabbits consuming cholesterol experienced profound hypercholesterolemia and tissue lipid accumulation, with plasma cholesterol levels above 1500 mg/dl for all groups at the completion of the study. Liver and spleen lipid content and liver cholesterol content also increased. Aortic arch atheroma thickness was greatest in 1% cholesterol 10% fat 0.11% Mg animals. Tissue Mg levels decreased in cholesterol-fed animals compared to chow-fed controls, despite equal or greater serum Mg levels. Our results indicate that the 1% cholesterol 10% fat 0.11% Mg diet was optimal at promoting hypercholesterolemia and atherosclerosis while minimizing health complications for the animals. The low Mg cholesterol diet will be useful to other biomedical researchers interested in utilizing the rabbit for cardiovascular disease research.

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Influence of dietary unsaturated and saturated fat on the plasma lipoproteins of mongolian gerbils

Cited by 29 publications

References 48 publications

The effect of dietary lipid on the lipoprotein status of the mongolian gerbil

The effect of dietary lipid on the lipoprotein status of the mongolian gerbil

Analysis, Heat Stability and Physiological Effects of Saponins from Oats

Optimization of a Low Magnesium, Cholesterol-Containing Diet for the Development of Atherosclerosis in Rabbits

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