Influence of Dietary Protein Concentration and Quality on Response to Erythropoietin in the Polycythaemic Rat

Alippi, Rosa M.; Giglio, J. M.; Barceló, Ana C.; Bozzini, Carlos E.; Farina, Rosario; Río, M. E.

doi:10.1111/j.1365-2141.1979.tb03772.x

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…The data really indicate that acute starvation, and protein deprivation to a lesser extent, effectively inhibit red cell production in post-hypoxic polycythemic mice in which initiation of erythropoiesis was induced by exogenous EPO, thus confirming previous results obtained in rats [2,4]. Unexpected observations were that both feeding conditions depressed the response to EPO when applied during the 48-how post-injection period and were ineffective when applied during the 48-hour pre-injection one.…”

Section: Discussionsupporting

confidence: 88%

“…Studies performed in our laboratory confirmed these findings and extended them to the water-deprived, polycythemic rat [3]. Furthermore, they also showed that the ability of rats to respond normally to EPO is dependent on a continuous dietary intake of proteins at levels which are dependent on their biological values [4]. Fondu et al [5] also reported that the responsiveness of the bone marrow to EPO is impaired in humans with protein-energy malnutrition.…”

Section: Introductionsupporting

confidence: 61%

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Impaired Response of Polycythemic Mice to Erythropoietin Induced by Protein Starvation Imposed After Hormone Administration

et al. 1993

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The present study was performed to determine the stage of the erythropoietic pathway which is affected by starvation or protein deprivation and whose manifestation is a depressed response to exogenous erythropoietin (EPO). The response to recombinant human EPO was measured in post-hypoxic polycythemic mice by determination of 59Fe uptake into red cells, spleen and femur and/or erythroid colony forming units (CFU-E) and erythroid precursor cell concentrations in femoral marrow. Experimental mice were either starved or fed one of seven different diets whose protein (casein) content ranged from 0 to 20%. All diets were isocaloric. The response of mice maintained on the standard diet (Purina Lab chow) was taken as the normal one. Starvation during the 48-hour period immediately before EPO injection had no effect on the response to the hormone. Starvation, and protein deprivation to a lesser extent, during the 48-hour period following EPO, on the other hand, significantly reduced the response. There was a progressive increase in the response as the casein content of the diet was increased. A normal response was observed when dietary casein concentration was 10%. These findings indicate that nutritional deprivation or dietary protein alterations during the period immediately following EPO injection in polycythemic mice can have detrimental effects on the erythroid response in a model in which nutritional deprivation was relatively short and acute. They also indicate that the subnormal response is not due to a decreased size of the erythroid progenitor pool available for differentiation but to deficient rates of differentiation of erythropoietic units.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionsupporting

confidence: 61%

Impaired Response of Polycythemic Mice to Erythropoietin Induced by Protein Starvation Imposed After Hormone Administration

et al. 1993

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“…They were housed in stainless-steel cages and were fed a diet containing 20% casein (Alippi et al, 1979), which has been shown to meet all necessary requirements for adequate growth of rats, and water ad libitum. Three days after being weaned, 10 animals were selected randomly and killed (initial control rats).…”

Section: Methodsmentioning

confidence: 99%

Mandibular Growth Retardation in Growing Rats Chronically Exposed to Hypobaria

1987

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Weanling male Wistar rats aged 21 days were divided into three groups: initial control, normobaric, and hypobaric (C, N, and H, respectively). C rats were killed three days after being weaned. H rats were placed into an altitude chamber and maintained at 456 mb (6100 m) for 14 days. N rats were maintained at sea-level conditions. Body weight, body and tail lengths, and food intake were recorded every day. Animals were killed at the end of the experimental period, and four linear dimensions of the dried mandible were measured. The amount of food eaten by the H rats during the entire exposure period was 54.6% of that consumed by N ones. Body weight gain in H rats was 32.7% of that seen in N rats. Body length was 49.0% and tail length was 56.6% of normal. All mandibular dimensions were significantly reduced in H rats when compared with N rats and were, in general, in close relation with the reduction observed in skeletal growth. Only one dimension was reduced out of proportion, which indicates some deformation of the mandible. The average daily caloric intake related to metabolic body weight (body weight 0.75) of H rats was 60% of the N value. Efficiency of protein utilization for growth was not significantly different between both groups of rats. These results indicate that chronic exposure to hypobaria induces overall skeletal and mandibular growth retardation, which appears to be the result of a diminution in food intake because of decreased appetite.

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High-Altitude Polycythemia

Winslow

1984

High Altitude and Man

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Influence of Dietary Protein Concentration and Quality on Response to Erythropoietin in the Polycythaemic Rat

Cited by 5 publications

References 8 publications

Impaired Response of Polycythemic Mice to Erythropoietin Induced by Protein Starvation Imposed After Hormone Administration

Impaired Response of Polycythemic Mice to Erythropoietin Induced by Protein Starvation Imposed After Hormone Administration

Mandibular Growth Retardation in Growing Rats Chronically Exposed to Hypobaria

High-Altitude Polycythemia

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