Influence of dietary fibers on lipid digestion: Comparison of single-stage and multiple-stage gastrointestinal models

Assadpour

Comp Rev Food Sci Food Safe

et al. 2020

188

108

Nowadays, many consumers prefer foods with a high content of nutraceuticals that contribute to the prevention or healing of chronic diseases. Therefore, in recent years, more and more researchers have studied the bioefficiency, safety, and toxicity of nutraceutical-enriched foods. The key stage of nutraceutical bioefficiency is oral bioavailability, which involves the following processes: the release of nutraceuticals from food matrices or nanocarriers in gastrointestinal fluids, the solubilization of nutraceuticals and their interaction with other components of gastrointestinal fluids, the absorption of nutraceuticals by the epithelial layer, and the chemical and biochemical transformations into epithelial cells. These processes are endogenous factors that greatly influence the bioavailability of nutraceuticals. In addition to endogenous factors, the bioavailability of nutraceuticals is also affected by exogenous factors, such as: physicochemical properties of nutraceuticals, food matrix, food processing and storage, and so forth. Both the endogenous and exogenous factors are comprehensively analyzed in this review. Thus, the physicochemical and enzymatic processes involved in food digestion are described, highlighting the role of each stage of gastrointestinal tract (mouth, stomach, and intestine) in nutraceuticals bioaccessibility. The structure and functions of the mucus and epithelial layers, the mechanisms involved in the active and passive transport of nutraceuticals through the cell membrane, and phase I and phase II metabolism reactions are also discussed. Finally, this review focuses on several types of bioactive-loaded nanocarriers such as lipid-based, surfactant-based, and biopolymeric nanocarriers that improve the bioavailability of nutraceuticals. K E Y W O R D Sbioaccessibility, bioavailability, food matrix, gastrointestinal fate, nanocarriers, nutraceuticals 954

“…Similar results were also reported by Qin et al. (2017) who studied the digestion of emulsions stabilized by chitosan, sodium alginate, and β‐lactoglobulin.…”

Section: Gastrointestinal Factors Affecting the Nutraceutical Bioavaisupporting

confidence: 89%

Section: External Factors Affecting the Nutraceutical Bioavailabilitymentioning

confidence: 99%

Section: External Factors Affecting the Nutraceutical Bioavailabilitymentioning

confidence: 99%

Section: Gastrointestinal Factors Affecting the Nutraceutical Bioavaimentioning

confidence: 99%

See 2 more Smart Citations

Bioavailability of nutraceuticals: Role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems

Assadpour

Comp Rev Food Sci Food Safe

et al. 2020

188

108

“…One of the bold reformulation strategies proposed for obesity management is to directly control digestion and absorption of lipids by manipulating physiochemical and structural attributes of food product matrices. Functional colloids such as nanolaminated emulsions, encapsulates, coated droplets, and mechanically processed nanocellulose have been employed to control lipid digestion and absorption. Decreased lipolysis in upper part of GIT is also believed to trigger the perception of satiety by activating negative feedback mechanism (called as ileal brake) in the most distal part of upper intestine .…”

Section: Emerging Application Of Functional and Engineered Food Colloidsmentioning

confidence: 99%

Functional and Engineered Colloids from Edible Materials for Emerging Applications in Designing the Food of the Future

Patel

2018

Adv Funct Materials

102

Functional and engineered colloids fabricated from edible materials have recently gained a lot of interest for futuristic applications in the field of foods for purposes ranging from microstructure development to delivery of healthpromoting bioactives to manipulation of food-body interactions. This review tackles a very ambitious task of discussing the current understanding of functional colloids within the framework of foods. Physicochemical attributes of several novel complex colloids fabricated from natural, and often, underutilized edible materials are clearly and comprehensively reviewed in this paper. This review not only provides a scientific insight into the advances made in the field of colloid-based food structuring but also touches on the exciting future opportunities in this promising multidisciplinary field.

Euro J Lipid Sci & Tech

Preparation, Characterization, and Gastrointestinal Digestion of Triterpenol‐Loaded Liposomes

Sun

Guo

Liu

et al. 2023

Triterpenol is an important phytochemical that is beneficial to humans. However, there are limitations of application due to its poor solubility. Liposomes are increasingly utilized as a delivery system for phytochemicals with poor solubility which is suitable for triterpenol. In the present study, the stability of triterpenol‐loaded liposomes (Tri‐LP) is demonstrated. Tri‐LP stability is observed when the mass ratio of phospholipids to triterpenol is 4:1. Sodium alginate (ALG) and chitosan showed different effects on Tri‐LP. Tri‐LP coated by ALG (Tri‐LP‐ALG) is stabilized by H‐bonding, while electrostatic interactions can stabilize Tri‐LP coated by chitosan (Tri‐LP‐CH). Tri‐LP‐ALG is more stable than Tri‐LP‐CH during storage. The bioaccessibility of Tri‐LP is 11%. ALG and chitosan show no influence on bioaccessibility of Tri‐LP, but reduce the release rate of triterpenol during digestion. Overall, the findings suggest that Tri‐LP showed good promise for future application in functional beverages. Practical Applications: Triterpenol has poor solubility both in oil and water, which greatly limits the functional utilization of triterpene in organisms. Liposomes offer a novel approach to triternenol oral delivery system. It meets the current demands for food health. Liposomes can improve the absorption and utilization of triterpenol in vivo digestion. Many studies and applications of liposomes has carried out in medical field while nutritional supplements with liposomes technology are not common in the market. Triterpenol‐loaded liposomes can not only increase applications in phytochemicals with poor absorption but also offer an interesting attempt of liposomes in food development.