Influence of Dietary Fiber on Inflammatory Bowel Disease and Colon Cancer: Importance of Fermentation Pattern

Rose, Devin J.; DeMeo, Mark T.; Keshavarzian, Ali; Hamaker, Bruce R.

doi:10.1111/j.1753-4887.2007.tb00282.x

Cited by 142 publications

(92 citation statements)

References 86 publications

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“…The nixtamalized corn pericarp is a good source of dietary fiber (DF). Although the benefits of DF were originally focused on increasing fecal volume, and laxative properties (Ramulu & Rao, 1997), today it is recognized that DF plays an important role in various physiological functions as well as in the prevention and treatment of different diseases (Dhingra, Michael, Rajput, & Patil, 2012;Rose, DeMeo, Keshavarzian, & Hamaker, 2007). There are several definitions for this DF (Englyst, Quigley, & Hudson, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Now that food labeling for DF is uniform around the world, we still have to arrive at a definition which will include those plant oligo-and polysaccharides which do not precipitate in 78% ethanol and which are not hydrolyzed by the enzymes of the small intestine (Dhingra et al, 2012;Prosky, 2008). Based on its solubility in water, DF is classified as soluble (SDF), including pectin and gums, and insoluble (IDF), including cellulose, hemicellulose, and lignin (Dreher, 1987;Rose et al, 2007). Nowadays, it is considered that the daily consumption of an adult should be between 20 and 35 g of DF, of this at least 15 g/day being SDF.…”

Section: Introductionmentioning

confidence: 99%

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Effects of extrusion process in snacks of oats–nixtamalized corn pericarp mixtures on dietary fiber content and functional properties

Zambrano-Zaragoza

Gutiérrez-Cortez

Jiménez-Vieyra

et al. 2013

CyTA - Journal of Food

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(2013) Effects of extrusion process in snacks of oats-nixtamalized corn pericarp mixtures on dietary fiber content and functional properties, CyTA -Journal of Food, 11:sup1, 38-45, DOI: 10.1080/19476337.2012 The aim this work was to establish the best conditions to increase the soluble dietary fiber (SDF), evaluate the effect of extrusion on the SDF, and insoluble dietary fiber (IDF), in a snack obtained by extrusion, that serve as a source of calcium and DF, using mixtures of oat-corn pericarp. The corn pericarp was obtained from byproduct of nixtamalization process which contains water, calcium hydroxide, soluble solids, and pericarp. The studied parameters were temperature (120-1408C), moisture (200-400 g/kg), and corn pericarp (200-400 g/kg); the responses were expansion ratio, SDF, IDF, and water absorption index (WAI). The R 2 were 4 0.85 for all factors. The best conditions were temperature (1338C), moisture (230 g/kg), and corn pericarp (300 g/kg), with responses of 93.1 g/kg increase in SDF, 60 g/kg decrease of IDF, expansion of 1.26, WAI of 4.12 g sediment/g dry solid, and calcium content 4350 mg/kg.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of extrusion process in snacks of oats–nixtamalized corn pericarp mixtures on dietary fiber content and functional properties

Zambrano-Zaragoza

Gutiérrez-Cortez

Jiménez-Vieyra

et al. 2013

CyTA - Journal of Food

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“…The benefits of fiber against colon cancer were closely associated to both the fermentative and the non-fermentative processes, where the poorly fermentable fibers were regarded to be more influential [3]. Dietary fibers are viscous, indigestible polysaccharides derived from plant foods which are not degraded by enzymes of the alimentary tract; therefore, they reach the colon undegraded and serve as potential fermentation substrates for the colon microorganisms, particularly bacteria [3,4].…”

Section: Introductionmentioning

confidence: 99%

Degradation of dietary fiber by faecal bacteria and potential physiological effects.

Uzomah¹,

Ofuya²

2009

African Journal of Food, Agriculture, Nutrition and Development

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Dietary fiber was extracted from Nigerian 'gari', Ex Mannihot esculenta; plantain, Musa paradisiaca; Gnetum africana and Telfaria occidentalis and these fiber sources were referred to as GAF, PLF, GF and TF, respectively. Mannihot esculenta and Musa paradisiaca are rich sources of carbohydrate and the fiber extraction was done using termamyl 120L and amyloglucosidase. Gnetum africana and Telfaria occidentalis are vegetables and the acetone dried powder method was employed for fiber extraction. The fiber extracted from each source was subjected to degradation by the gut microbial flora and the extent of degradation after 72 h was determined. Water holding capacity (WHC) of each fiber was measured before and after the degradation. The short chain fatty acids (SCFA) produced during degradation were measured chromatographically. Exposure of the fibers to the gut microflora showed that the non-vegetable fibers (GAF, PLF) were more readily degraded than the vegetable fibers (GF and TF). Consequently, the percentage of the undegraded fiber after 72 h of incubation was highest with the vegetable fibers; GF, 80.0 % and TF, 83.3 %, while that of the non-vegetable fibers (GAF and PLF) was 62.0 % and 72.5 %, respectively. The degradation by the microflora affected the WHC of the fibers (except TF). Water holding capacity (WHC) for GF was 11.1 ± 3.3 g H 2 O / g fiber, before degradation and 6.3 ± 2.5 g H 2 O / g fiber after degradation, indicating a percent decrease of about 43.2%. Similar decrease was observed for GAF (30.4 %) and PLF (13.9 %). Only acetic and butyric acid were detected in the fermenting slurry. The relative composition of acetic acid from each of the fiber source (GAF, 62.0 %; PLF, 70.4%; GF, 62.5%; TF, 52.9%) was found to be greater than that from the slurry (control) (42%). The low pH created by the actions of the microflora in the caecal lumen will decrease the toxicity of luminal contents to the gut mucosa and protect against cancer of the colon

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“…According to Rose et al 6 , fibers could work as anticarcinogenic components by several mechanisms. One of them includes the fermentation of soluble fibers in the colon by the intestinal microflora producing short-chain fatty acids (SCFA) 6 .…”

Section: Introductionmentioning

confidence: 99%

“…One of them includes the fermentation of soluble fibers in the colon by the intestinal microflora producing short-chain fatty acids (SCFA) 6 . The SCFA include acetate, propionate, butyrate and isobutyrate, which are fuels for the cells of the colonic mucosa 7 .…”

Section: Introductionmentioning

confidence: 99%

Sodium butyrate does not decrease the evolution of precancerous lesions in rats

Silva¹,

Penido²,

Valente³

et al. 2010

Acta Cir. Bras.

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Purpose:To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH). Methods: Forty Wistar rats were separated into four groups (n=10) distributed as follows: control 1, control 2, butyrate 1 and butyrate 2. The groups control 1 and butyrate 1 remained under experimentation for 4 weeks, while the groups control 2 and butyrate 2 remained for 8 weeks. In the first four weeks, the animals of the control groups received water ad libitum and the animals of the butyrate groups received a sodium butyrate solution (3.4%) ad libitum. Injections of the drug 1,2-dimethylhydrazine were applied during the two first weeks of the experiment in all the animals, concurrently with the application of sodium butyrate. The large intestine of the animals was removed, for the analysis of the ACF and of the content of polyamines. The animal feces were collected for the analysis of the SCFA profile. Results: The spermidine presented a higher concentration in the group butyrate 2 in comparison to the group control 2. There was a significant difference in the concentration value (µmol/mL) of acetate in comparison to the groups control 2 and butyrate 2. Conclusion: The use of sodium butyrate together with the induction of colorectal cancer was not effective in the prevention of the disease progression. Key words: Colonic Neoplasms. Precancerous Conditions. Butyrates. Rats. RESUMO Objetivo:Avaliar o efeito preventivo do butirato de sódio no surgimento de focos de cripta aberrante (FCA) em ratos após a indução com o carcinógeno 1,2-dimetilhidrazina. Métodos: Quarenta ratos foram divididos em quatro grupos, com dez animais em cada. Os grupos controle 1 e butirato 1 ficaram em experimentação por 4 semanas e os grupos controle 2 e butirato 2 por oito semanas. Nas primeiras quatro semanas, os animais dos grupos controle receberam água ad libitum e os animais dos grupos butirato receberam solução de butirato de sódio (3,4%) ad libitum. Em todos os animais foram aplicadas quatro injeções subcutâneas da droga 1,2-dimetilhidrazina nas duas primeiras semanas, concomitante a administração do butirato de sódio. Foi retirado o intestino grosso dos animais, para análise dos FCA e do teor de poliaminas. As fezes dos animais foram recolhidas para análise do perfil de AGCC. Resultados: A espermidina apresentou maior concentração no grupo butirato 2 em relação ao grupo controle 2. Foi encontrada diferença significativa no valor da concentração de acetato quando comparado os grupos controle 2 e butirato 2. Conclusão: A utilização do butirato de sódio concomitante à indução do câncer colorretal não se mostrou efetiva na prevenção da progressão da doença. Descritores: Neoplasias do Colo. Lesões Pré-Cancerosas. Butiratos. Ratos.

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Influence of Dietary Fiber on Inflammatory Bowel Disease and Colon Cancer: Importance of Fermentation Pattern

Cited by 142 publications

References 86 publications

Effects of extrusion process in snacks of oats–nixtamalized corn pericarp mixtures on dietary fiber content and functional properties

Effects of extrusion process in snacks of oats–nixtamalized corn pericarp mixtures on dietary fiber content and functional properties

Degradation of dietary fiber by faecal bacteria and potential physiological effects.

Sodium butyrate does not decrease the evolution of precancerous lesions in rats

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