Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes—The TOSCA.IT Study

Vitale, Marilena; Masulli, Maria; Rivellese, Angela Albarosa; Babini, A. C.; Boemi, Massimo; Bonora, Enzo; Buzzetti, Raffaella; Ciano, Ornella; Cignarelli, Mauro; Cigolini, M.; Clemente, Gennaro; Citro, Giuseppe; Corsi, L.; Dall'Aglio, E; Prato, Stefano Del; Cianni, Graziano Di; Dolci, Maria; Giordano, Carla; Iannarelli, R.; Iovine, C; Lapolla, Annunziata; Lauro, Davide; Leotta, Sergio; Mazzucchelli, Chiara; Montani, V.; Perriello, G.; Romano, G.; Romeo, Francesco; Santarelli, L.; Cola, Rita Schiano di; Squatrito, Sebastiano; Tonutti, Laura; Trevisan, Riccardo; Turco, Anna; Zamboni, Chiara; Riccardi, Gabriele; Vaccaro, Olga

doi:10.1007/s00394-015-0983-1

Cited by 46 publications

(37 citation statements)

References 28 publications

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“…Our data confirm previous findings suggesting that compliance with nutritional recommendations for diabetes is extremely low and that carbohydrates intake in persons receiving treatment for diabetes is lower than the general population [23,24]. In persons with diabetes, complex carbohydrates intake is beneficial and fat-rich and simple sugar-containing foods should be avoided [25].…”

Section: Discussionsupporting

confidence: 88%

Nutrients Intake in Individuals with Hypertension, Dyslipidemia, and Diabetes: An Italian Survey

et al. 2020

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The aim of this study is to evaluate whether nutrients intake in an Italian adult population receiving pharmacological treatment for hypertension, dyslipidemia, and diabetes are within the recommended values proposed by dietary guidelines. Cross-sectional data from the Cardiovascular Epidemiology Observatory/Health Examination Survey in 8462 individuals 35–79 years were used. Food consumption was assessed with a self-administered semi-quantitative food frequency questionnaire. Dietary sodium and potassium intakes were measured in 24-hour urine collection. Recommendations from WHO were used for salt and potassium intakes, those from the Diabetes and Nutrition Study Group for diabetes, and those from the European Society of Cardiology for hypertension and dyslipidemia. Salt intake in urine collection of participants receiving treatment for hypertension was 11.1 ± 4.0 g/day for men and 8.6 ± 3.3 g/day for women, higher than recommended. In participants treated for dyslipidemia, mean saturated fat intake was 11.4% and 11.6% total Kcal in men and women respectively, higher than recommended, while cholesterol intake was higher only in men (365.9 ± 149.6 mg/day). In both men and women receiving treatment for diabetes, mean intake of saturated fats (12.3% and 12.2% of total Kcal), simple carbohydrates (17.5% and 19.8% of total Kcal) and cholesterol (411.0 ± 150.4 and 322.7 ± 111.1 mg/day) were above the recommendations, while fiber intake was below (19.5 ± 6.3 and 17.5 ± 6.2 mg/day). Overall, 70% to 80% of participants treated for these conditions received advice from family doctors on dietary management; however, nutrition is far from being optimal.

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Section: Discussionsupporting

confidence: 88%

Nutrients Intake in Individuals with Hypertension, Dyslipidemia, and Diabetes: An Italian Survey

et al. 2020

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“…As a matter of fact, the main contributor to phenolic acids intake is represented by non-alcoholic beverages and the added sugars generally utilized in these drinks could have counteracted or masked the relationship between phenolic acids and glucose control. Within this context, it is important to underline that in the same population a positive association was found between added sugars and HbA1c concentrations [28].…”

Section: Discussionmentioning

confidence: 92%

Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study

et al. 2017

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“…It is plausible that obese children could have dysregulation in the hepatic acute-phase response leading to an elevation in CRP, rather than CRP being a marker of a systemic inflammatory response. Another possible explanation is that IL-6 and TNF-α elevation may only occur transiently, in response to metabolic stress related to food intake [44]. …”

Section: Discussionmentioning

confidence: 99%

Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study

Hursh

Fazeli²,

Wang³

et al. 2016

Horm Res Paediatr

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Background/Aims: The autonomic nervous system (ANS) provides neurogenic control of inflammatory reactions. ANS changes in obesity may result in inflammation. This study sought to gain insight into cardiac autonomic dysfunction and inflammation in childhood obesity, and to gather pilot data on the potential relationship between altered ANS and inflammation. Methods: Fifteen obese children and adolescents without metabolic complications and 15 nonobese controls underwent heart rate variability and impedance cardiography testing during rest, mental stress, and physical stress. Inflammatory cytokines and immune reactivity were measured. Results: There was no statistically significant difference between groups in cardiac ANS testing at rest or in response to stress. Median high-sensitivity C-reactive protein (hsCRP) was higher in the obese group [obese 2.6 mg/l (IQR 1.6-11.9); nonobese 0.3 mg/l (IQR 0.2-0.7); p < 0.001]. Interleukin-6 and tumour necrosis factor-α were similar between groups. Immune reactivity testing (in vitro Toll-like receptor stimulation) revealed a strong, but comparable, inflammatory response in both groups. Conclusions: Obese children and adolescents without metabolic complications did not have cardiac ANS dysfunction. While hsCRP was elevated, systemic cytokines were not raised. Compared to prior studies, which often focused on children with obesity and its complications, it is encouraging that obese children without metabolic complications may not yet have autonomic dysfunction.

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Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes—The TOSCA.IT Study

Cited by 46 publications

References 28 publications

Nutrients Intake in Individuals with Hypertension, Dyslipidemia, and Diabetes: An Italian Survey

Nutrients Intake in Individuals with Hypertension, Dyslipidemia, and Diabetes: An Italian Survey

Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study

Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study

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