Influence of Diet and Feed Restriction on Kidney Function of Aging Male Rats

Tucker, S. M.; Mason, Rossie L.; Beauchene, Roy E.

doi:10.1093/geronj/31.3.264

Cited by 75 publications

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“…ADR of rats during the second year of life delayed age-related alterations in kidney. function and reduced the incidence and severity of renal lesions (24 …”

Section: Discussionmentioning

confidence: 99%

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Modification of age-related immune decline in mice dietarily restricted from or after midadulthood.

Weindruch¹,

Gottesman²,

Walford³

1982

Proc. Natl. Acad. Sci. U.S.A.

112

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Although weaning-initiated dietary restriction of rodents is known to increase maximum survivorship and inhibit spontaneous late-life disease and immunologic aging, restriction begun in adulthood has been much less thoroughly evaluated. In the present studies, male mice ofa long-lived F1 (4)(5)(6) and is the only strategy known to slow age-related increases in mortality rates in homeotherms (7). Restriction also inhibits or delays (or both) the occurrence of many late-life diseases (8)(9)(10)(11) and retards the development of immunosenescence (12)(13)(14)(15)(16) (23) and rats (24). With regard to immunologic effects, only mouse splenocyte mitogen-induced T-cell proliferative responses (which are known to decline with age) have been looked at. These were increased in 16-to 17-mo-old mice restricted from 12 mo of age (14) and in 22-mo-old mice restricted from 17 mo of age (25).The present studies, done with male mice of the long-lived (C3H.SW/Sn X C57BL10.RIII/Sn) F1 strain (C3B10RF,),were aimed at providing further information on the impact of gradually imposed adult-initiated diet restriction on immunologic aging and spontaneous cancer incidence.MATERIALS AND METHODS Mice. C3B1ORF1 mice bred in our animal facilities were studied. Those fed Purina lab chow ad lib have a mean lifespan of ""28 mo, and those restricted at weaning have a mean lifespan of "-40 mo. Lifespan was not determined in the present experiments as all mice were killed and studied for immune parameters and cancer incidence. Stimulator cells in the cell-mediated lymphocytotoxicity (CML) study came from DBA male mice (H-2d; Jackson Laboratories).Diet Strategies. Three hundred male mice weaned at 3 to 4 wk of age were housed in groups of 4-6 with free access to Purina lab chow. At 12 mo, mice were individually caged and randomly assigned to one of two diet categories. (i) Purina 898The publication costs ofthis article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.

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“…ADR of rats during the second year of life delayed age-related alterations in kidney. function and reduced the incidence and severity of renal lesions (24 …”

Section: Discussionmentioning

confidence: 99%

“…However, these rats did not consume a nutrient-enriched diet and restriction was not gradually imposed. Even (8) and renal disease in mice (23) and rats (24). With regard to immunologic effects, only mouse splenocyte mitogen-induced T-cell proliferative responses (which are known to decline with age) have been looked at.…”

mentioning

confidence: 99%

Modification of age-related immune decline in mice dietarily restricted from or after midadulthood.

Weindruch¹,

Gottesman²,

Walford³

1982

Proc. Natl. Acad. Sci. U.S.A.

112

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“…108 Food restriction during the first few years of life in the rat decreases proteinuria, increases para-aminohippuric acid transport and reduces the incidence and severity of renal lesions, therefore delaying age-related detrimental changes in kidney function. 109,110 In a recent study, control groups of SD male rats were food restricted to 25 and 50% of the ad libitum fed control group, for 2 weeks or were 100% restricted for 1 day only (unpublished data). All restricted animals showed depleted levels of urinary TCA cycle intermediates and relatively small increases in creatine, due to muscle breakdown, along with a concomitant increase in creatinine and taurine.…”

Section: Metabonomic Studies Of Physiological Variationmentioning

confidence: 99%

NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition

et al. 2004

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Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these approaches, toxicological response can be measured by terms of deviation from control or baseline status. However, in order to accurately define drug-induced response, it is necessary to characterize the normal degree of physiological variation in the absence of stimuli. Here, 1 H NMR spectroscopic-based analyses of the metabolic composition of urine in experimental animals under various normal physiological conditions are reviewed. In particular, the effects of inter-animal and diurnal variation, gender, age, diet, species, strain, hormonal status and stress on the biochemical composition of urine are explored. Pattern recognition methods facilitate the comparison of urine NMR spectra over a given time-course, enabling the establishment of changes in profile and highlighting the dynamic metabolic status of an organism. Thus metabonomic approaches based on information-rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues.

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“…Food restriction inhibits the development of age-associated renal disease [Saxton and Kimball, 1941;Berg and Simms, 1960;Bras and Ross, 1964;Tucker et al, 1976] in the rat. Although caloric intake appears to be the main factor in the development of renal le sions, dietary protein has also been impli cated [Newburgh and Curtis, 1928;Bras and Ross, 1964;Lalich et al, 1970].…”

mentioning

confidence: 99%

Effects of Caloric Intake and Dietary Composition on the Development of Proteinuria, Age-Associated Renal Disease and Longevity in the Male Rat

Everitt

Porter

Wyndham³

1982

Gerontology

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The development of age-associated proteinuria and renal disease was studied in groups of male Wistar rats fed 12.5, 25, 50 and 75 kcal of food/day, respectively, and in calorie-restricted (40 kcal/day) rats receiving diets rich in fat, protein or carbohydrate. Proteinuria developed faster, kidneys were larger and the incidence of glomerular lesions and proteinaceous casts was greater in rats eating high calorie diets of 50 kcal/day or more. High protein diets, even when calorie-restricted, increased protein excretion and the incidence of glomerular lesions. In old rats acute food restriction (25 kcal/day) decreased protein excretion by 40 % in 1 week, with no further reduction in the 2 week. Life duration was greatest in rats fed 50 kcal/day.

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Influence of Diet and Feed Restriction on Kidney Function of Aging Male Rats

Cited by 75 publications

References 0 publications

Modification of age-related immune decline in mice dietarily restricted from or after midadulthood.

Modification of age-related immune decline in mice dietarily restricted from or after midadulthood.

NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition

Effects of Caloric Intake and Dietary Composition on the Development of Proteinuria, Age-Associated Renal Disease and Longevity in the Male Rat

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