Influence of dialysis modalities on serum AGE levels in end‐stage renal disease patients

Stein, Günter; Franke, Sybille; Mahiout, A; Schneider, Sabine; Sperschneider, H; Borst, Sabine; Vienken, Jörg

doi:10.1093/ndt/16.5.999

Cited by 68 publications

(57 citation statements)

References 27 publications

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“…The site evolves from a fatty streak into histologically complex lesions characteristic of fully fledged atherosclerosis. 10,[12][13][14] The present study showed that the intensity of the pentosidine staining was higher in the veins compared with the arteries, especially in the presence of type 2 DM. Tokgoz et al have reported that patients with ESRD have a higher tendency of getting vein thrombosis, 15 and the concomitant presence of diabetes and renal disfunction can enhance platelet activity and blood clot formation.…”

Section: Discussionmentioning

confidence: 84%

Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients

et al. 2006

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The excess accumulation of advanced glycation end products (AGEs) contributes to the chronic complications of type 2 diabetes mellitus (DM) and renal failure. Biopsy specimens ( n = 184) of arterial ( n = 92) and venous ( n = 92) tissues were obtained (radial artery and cephalic vein) from end-stage renal disease (ESRD) patients with or without DM and normal healthy subjects ( n = 12) requiring surgery (trauma patients). Immunohistochemical assessment of the blood vessels revealed the presence of pentosidine (AGE marker) in both veins and arteries in 72% of the ESRD patients. The percentage of arteries and veins that showed positive pentosidine staining in ESRD patients with type 2 DM alone was 100% and 92% respectively, in the non-diabetic ESRD patients it was <70% (for arteries and veins), and in the ESRD patients with hypertension as an additional co-morbidity to type 2 DM it was 70% and 82%, respectively. The veins of ESRD patients with DM showed a strong (+++) positive staining and very strong (++++) positive staining was observed in the patients with DM and hypertension. Only mild (+) or moderate (++) pentosidine staining intensity was observed in the arteries of ESRD patients without or with comorbidities, respectively. The accumulation of AGE in the vein rather than the artery may be a better reflection of the extent of complications of ESRD.

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Section: Discussionmentioning

confidence: 84%

Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients

et al. 2006

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“…Membranes with high permeability can, therefore, decrease blood AGEs by up to 60% 164 and up to 80% with high-flux polysulfone. 165,166 Lin et al 167 showed that online hemodiafiltration, a combination of both HF and HD, for .6 months in patients with uremia leads to a significant reduction in serum AGE levels. A recent study showed that convective therapies not only effectively cleared uremic toxins but also, decreased levels of inflammatory markers, such as IL-6.…”

Section: Inhibition Of Gastrointestinal Absorptionmentioning

confidence: 99%

Uremic Toxicity of Advanced Glycation End Products in CKD

Stinghen

Massy

Vlassara

et al. 2016

Journal of the American Society of Nephrology

192

175

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Advanced glycation end products (AGEs), a heterogeneous group of compounds formed by nonenzymatic glycation reactions between reducing sugars and amino acids, lipids, or DNA, are formed not only in the presence of hyperglycemia, but also in diseases associated with high levels of oxidative stress, such as CKD. In chronic renal failure, higher circulating AGE levels result from increased formation and decreased renal clearance. Interactions between AGEs and their receptors, including advanced glycation end product-specific receptor (RAGE), trigger various intracellular events, such as oxidative stress and inflammation, leading to cardiovascular complications. Although patients with CKD have a higher burden of cardiovascular disease, the relationship between AGEs and cardiovascular disease in patients with CKD is not fully characterized. In this paper, we review the various deleterious effects of AGEs in CKD that lead to cardiovascular complications and the role of these AGEs in diabetic nephropathy. We also discuss potential pharmacologic approaches to circumvent these deleterious effects by reducing exogenous and endogenous sources of AGEs, increasing the breakdown of existing AGEs, or inhibiting AGE-induced inflammation. Finally, we speculate on preventive and therapeutic strategies that focus on the AGE-RAGE axis to prevent vascular complications in patients with CKD.

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“…Serum AGE circulate in the form of modified proteins or peptides and, in the case of pentosidine, also in their free form. 10 Glycated albumin is a type of albumin which is modified by Amadori glucose adducts and several studies have established that exposure of renal glomerular cells to non-enzymatically glycated albumin induces alterations in biosynthetic and signalling pathways that are involved in the pathogenesis of diabetic nephropathy. 11,12 Lamb et al 13 have found increased glycated albumin concentration in serum and dialysate of patients undergoing CAPD.…”

Section: Agementioning

confidence: 99%

The association of advanced glycation end-products with glutathione status

Şahin¹,

Göçmen²,

Koçak

et al. 2008

Ann Clin Biochem

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Background: The aim of this study was to investigate oxidative stress with regard to the concentrations of advanced oxidation protein products (AOPP), advanced glycation end-products (AGEs), pentosidine, glycated albumin, reduced glutathione (GSH) and oxidized glutathione (GSSG), glutathione redox ratios and thiobarbituric acid-reactive substances (TBARS) in nondiabetic patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Methods: The study group consisted of 52 non-diabetic CAPD patients and 34 healthy controls. AOPP, AGEs, pentosidine and glycated albumin were measured in plasma, whereas GSH, GSSG and TBARS concentrations were measured in erythrocytes of both patients and controls. Results: All parameters were found to be significantly increased, except the glutathione redox ratio, which was found to be decreased in patients undergoing CAPD. Multiple regression analysis showed that AGEs were the only independent predictor of glutathione redox ratio, whereas AGEs, glycated albumin and TBARS were each found to be independent predictors of albumin concentration. Conclusion: Our results support the hypothesis that oxidative stress and AOPPs/AGEs constitute important risk factors in CAPD patients. The negative relationship between albumin and both AGEs and TBARS suggests that the decrease in albumin may contribute to the increased advanced glycation and lipid peroxidation. The negative relationship between glutathione redox ratio and AGEs suggests that late products of glycation play an important role in the development of oxidative stress observed in patients undergoing peritoneal dialysis treatment.

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Influence of dialysis modalities on serum AGE levels in end‐stage renal disease patients

Abstract: Treatment with the biocompatible polysulfone SF dialyser seems to be better suited to lower serum AGE levels and to eliminate their precursors.

Cited by 68 publications

References 27 publications

Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients

Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients

Uremic Toxicity of Advanced Glycation End Products in CKD

The association of advanced glycation end-products with glutathione status

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