Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations

Yandrapalli, Srikanth; Malik, Aaqib H; Namrata, Fnu; Pemmasani, Gayatri; Bandyopadhyay, Dhrubajyoti; Vallabhajosyula, Saraschandra; Aronow, Wilbert S.; Frishman, William H.; Jain, Diwakar; Cooper, Howard A.; Panza, Julio A.

doi:10.1016/j.ijcard.2021.11.086

Cited by 6 publications

(8 citation statements)

References 20 publications

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“…Data from the 2014 US Nationwide Readmissions Database (NRD) showed that patients with diabetes had a 45% higher risk of being rehospiatlzied for heart failure after an AMI as compared to those without diabetes. 21 …”

Section: Discussionmentioning

confidence: 99%

Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study

Zammitti,

Tisminetzky,

Mehawej

et al. 2024

Journal of Multimorbidity and Comorbidity

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Background Multiple chronic conditions (MCCs) are common in patients hospitalized with acute myocardial infarction (AMI). We examined the association of 12 MCCs with the risk of a 30-day hospital readmission and/or dying within one year among those discharged from the hospital after an AMI. We also examined the five most prevalent pairs of chronic conditions in this population and their association with the principal study endpoints. Methods The study population consisted of 3,294 adults hospitalized with a confirmed AMI at the three major medical centers in central Massachusetts on an approximate biennial basis between 2005 and 2015. Patients were categorized as ≤1, 2-3, and ≥4 chronic conditions. Results The median age of the study population was 67.9 years, 41.6% were women, and 15% had ≤1, 32% had 2-3, and 53% had ≥4 chronic conditions. Patients with ≥4 conditions tended to be older, had a longer hospital stay, and received fewer cardiac interventional procedures. There was an increased risk for being rehospitalized during the subsequent 30 days according to the presence of MCCs, with the highest risk for those with ≥4 conditions. There was an increased, but attenuated, risk for dying during the next year according to the presence of MCCs. Individuals with diabetes/hypertension and those with heart failure/chronic kidney disease were at particularly high risk for developing the principal study outcomes. Conclusion Development of guidelines that include complex patients, particularly those with MCCs and those at high risk for adverse short/medium term outcomes, remain needed to inform best treatment practices.

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Section: Discussionmentioning

confidence: 99%

Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study

Zammitti,

Tisminetzky,

Mehawej

et al. 2024

Journal of Multimorbidity and Comorbidity

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“…In this context, cluster analyses have been recommended to identify groups with specific combinations of comorbidities, suggested as representative of patients with common pathophysiological mechanisms [7][8][9]. Among the comorbidities related to HF in older adults, traditional cardiovascular risk factors, including hypertension [7][8][9], alcohol consumption [9], diabetes [10,11], hypercholesterolemia [12][13][14], and smoking [15], play a fundamental role.…”

Section: Introductionmentioning

confidence: 99%

Clustering of Cardiovascular Risk Factors and Heart Failure in Older Adults from the Brazilian Far North

Ribeiro,

Moriguchi,

Pinto

2024

Healthcare

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Given the aging global population, identifying heart failure (HF) phenotypes has become crucial, as distinct disease characteristics can influence treatment and prognosis in older adults. This study aimed to analyze the association between clustering of cardiovascular risk factors and HF in older adults. A cross-sectional epidemiological study was conducted with 1322 older adults (55% women, mean age 70.4) seen in primary health care. Diagnosis of HF was performed by a cardiologist based on diagnostic tests and medical history. Cardiovascular risk factors included hypertension, diabetes, hypercholesterolemia, and smoking. Using logistic regression, potential associations were tested. Individual risk factor analysis showed that older adults with hypertension, diabetes, or hypercholesterolemia had up to 7.6 times higher odds to have HF. The cluster where older adults had only one risk factor instead of none increased the odds of HF by 53.0%. Additionally, the odds of older patients having HF ranged from 3.59 times for the two-risk factor cluster to 20.61 times for the simultaneous presence of all four factors. The analysis of clusters substantially increasing HF risk in older adults revealed the importance of individualizing subgroups with distinct HF pathophysiologies. The clinical significance of these clusters can be beneficial in guiding a more personalized therapeutic approach.

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“…Therefore, interventions for AF, either early and timely diversion therapy or anticoagulation for persistent AF, are necessary. According to epidemiological surveys, the number of patients with AF in the United States is expected to reach 7 million by 2050( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Meta‑analysis of the efficacy and safety of nifekalant in the conversion of atrial fibrillation

Liu

Wang

et al. 2022

Exp Ther Med

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Atrial fibrillation (AF) is the most common type of supraventricular tachyarrhythmia. Nifekalant is a new class III antiarrhythmic drug approved for the treatment of ventricular tachyarrhythmias, but its effectiveness in converting AF to sinus rhythm remains unclear. The present analysis aimed to investigate the effect of nifekalant in the conversion of AF. PubMed, Cochrane Library and China National Knowledge Infrastructure databases were systematically used to search relevant studies published between 1999 (data at which the drug was first approved for marketing in Japan) and 2022. Randomized clinical trials, prospective studies and retrospective studies on the use of nifekalant for AF were screened. The study metrics included the success rate of the conversion of AF, the mean time to conversion, the success rate of 12 months after a single AF catheter ablation procedure and the incidence of adverse events. The eligible studies screened included six randomized clinical trials, three prospective studies and three retrospective studies, totalling 12 studies with 1,162 patients. The risk ratio (RR) for successful conversion in the nifekalant and control groups was 1.95 [95% confidence interval (CI), 1.23-3.08; P=0.005] and the mean difference for the mean time to conversion was -1.73 [95% CI, -2.69-(-0.77); P= 0.0004]. Statistically significant differences were observed between nifekalant and control groups. Subgroup analysis revealed a statistically significant difference in the success rate of conversion following catheter ablation in the nifekalant group compared with the amiodarone group and the RR value was 1.95 (95% CI, 1.37-2.77; P= 0.0002). Statistically significant difference was observed compared with the electrical cardioversion group and the RR value was 0.90 (95% CI, 0.84-0.98; P=0.01). However, the combined RR values for the two groups were 1.18 (95% CI, 0.85-1.65; P<0.0002). The RR value for adverse events was 0.85 (95% CI, 0.51-1.43; P=0.55), with no statistically significant differences between nifekalant and control groups. In conclusion, the results demonstrated that the success rate and time to conversion in the nifekalant group were improved compared with those in the control group, particularly after catheter ablation, and the conversion effect with nifekalant was significantly improved compared with that in the control group.

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Influence of diabetes mellitus interactions with cardiovascular risk factors on post-myocardial infarction heart failure hospitalizations

Cited by 6 publications

References 20 publications

Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study

Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study

Clustering of Cardiovascular Risk Factors and Heart Failure in Older Adults from the Brazilian Far North

Meta‑analysis of the efficacy and safety of nifekalant in the conversion of atrial fibrillation

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