Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses

Deniau, V.; Depecker, Marianne; Bizon‐Mercier, Céline; Couroucé-Malblanc, Anne

doi:10.1111/vaa.12009

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…The treatment with epinephrine resulted in a decrease in spleen length of 78% on a dorso-caudal to ventro-cranial axis and 69% on a dorso-caudal to ventro-caudal axis, as well as an 84% reduction of splenic thickness in one study. Those results were not affected by previous use of detomidine or xylazine (Deniau et al 2013).…”

Section: Treatmentmentioning

confidence: 66%

“…This complication appears more likely in old horses (Frederick et al 2010). In countries where phenylephrine is not available, epinephrine can be used instead at a dose rate of 1 μg/kg bwt/min over 5 min (Deniau et al 2013). The treatment with epinephrine resulted in a decrease in spleen length of 78% on a dorso-caudal to ventro-cranial axis and 69% on a dorso-caudal to ventro-caudal axis, as well as an 84% reduction of splenic thickness in one study.…”

Section: Treatmentmentioning

confidence: 99%

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Left dorsal displacement of the large colon in the horse

Albanese

Caldwell

2013

Equine Veterinary Education

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Left dorsal displacement of the large colon is a condition unique to the horse that results in an obstruction of the colon and signs of colic. This condition may be successfully treated medically with analgesia, i.v. or oral fluids and feed restriction, exercise with or without administration of phenylephrine, or rolling under general anaesthesia with or without administration of phenylephrine, or a combination of these conservative options. Surgical correction via standing left flank laparotomy or, more commonly, ventral midline laparotomy under general anaesthesia, is required in cases where conservative therapy is unsuccessful. Recurrence rates range from 3.2% to 21%. Surgical attempts to prevent recurrence of this condition include large colon resection, colopexy, and ablation of the nephrosplenic space.

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Section: Treatmentmentioning

confidence: 66%

Section: Treatmentmentioning

confidence: 99%

Left dorsal displacement of the large colon in the horse

Albanese

Caldwell

2013

Equine Veterinary Education

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“…Donor platelet counts immediately after plateletpheresis were lower than expected considering the relatively low platelet yield in the platelet concentrate. It has been demonstrated that detomidine causes splenic relaxation and elongation, which can lead to both platelet and red blood cell sequestration . This may account for the lower than expected platelet and red blood cell counts immediately after the procedure as well as their quick recovery 8 hours later.…”

Section: Discussionmentioning

confidence: 99%

Platelet lysate obtained via plateletpheresis performed in standing and awake equine donors

et al. 2017

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“…Injectable phenylephrine was not available during the study period, with adrenaline being the only available alpha‐adrenergic agent. Due to the significant side effects of adrenaline administration, such as facial twitching, second‐degree atrioventricular block, profuse sweating and tachycardia, 31 adrenaline is rarely used as first‐choice alpha‐adrenergic drug in LDDLC cases.…”

Section: Discussionmentioning

confidence: 99%

Nephrosplenic space closure significantly decreases recurrent colic in horses: a retrospective analysis

et al. 2019

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Background Nephrosplenic space closure is commonly used to reduce relapse of nephrosplenic space entrapment in cases of left dorsal displacement of the left colon (LDDLC). Nevertheless, studies documenting the effectiveness of this surgery are sparse in the literature. The aim of this study was to analyse clinical data of horses presented for LDDLC and evaluate the effect of nephrosplenic space closure on the incidence of colic recurrence.Methods Medical records of 156 horses diagnosed with LDDLC at the Equine Clinic of the University of Liège between 2004 and 2016 were retrieved for analysis. Extracted data included horse breed, sex, age and weight, initial treatment, and if a subsequent preventive surgical closure of the nephrosplenic space was carried out or not. Follow-up information was obtained by telephone interview. Statistical analyses were performed using a chisquared test with significance set at P<0.05. Results Follow-up data were available for 65 per cent of horses. The mean follow-up was 35 months. There was a significant decrease in the total incidence of colic after closure surgery compared with non-operated horses. No horse was diagnosed with LDDLC after closure of the nephrosplenic space. Conclusion Closure of the nephrosplenic space significantly decreases recurrent colic in horses compared with non-operated horses.

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Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses

Cited by 13 publications

References 15 publications

Left dorsal displacement of the large colon in the horse

Left dorsal displacement of the large colon in the horse

Platelet lysate obtained via plateletpheresis performed in standing and awake equine donors

Nephrosplenic space closure significantly decreases recurrent colic in horses: a retrospective analysis

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