Influence of detectors efficiency normalization on small animal PET image quality

Santana, Mateus Gesulado Carneiro de; Souza, Guilherme Cavalcante de Albuquerque; Gontijo, Rodrigo Modesto Gadelha; Mendes, Bruno Melo; Ferreira, Andréa Vidal

doi:10.15392/bjrs.v7i3.861

Cited by 2 publications

(1 citation statement)

References 2 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The detector efficiency map is then obtained by normalizing the total detector counts with the object-dependent distribution [124]. As for clinical scanners, regular normalization is essential to guarantee accurate and artifact-free measurements in smallanimal studies [125].…”

Section: Normalizationmentioning

confidence: 99%

Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems

Amirrashedi

Zaidi

2020

Clin Transl Imaging

View full text Add to dashboard Cite

Aim Over the past two decades, innovations in small-animal positron emission tomography (PET) have reached an impressive level, which has brought countless opportunities to explore the major puzzles in biomedical research. It is a given that pairing information coming from different imaging modalities renders unprecedented knowledge and provides a great insight into various facets of biological systems, such as anatomy, function, physiology, and metabolism in animal models of human diseases, which are difficult to be beaten by standalone PET scanners. The development of bimodal and tri-modal imaging platforms with advanced software solutions dedicated for quantitative studies in small-animals has spurred academic and industrial interest. However, it is undisputed that the potential success of these scanners in filling the translational gap between human and animal findings, hinges to a great extent upon optimization and standardization of relevant parameters and acquisition protocols, which is often overlooked. Methods This article reviews the trends till 2020 in the field of preclinical PET imaging with emphasize on image reconstruction and quantitative corrections implemented on state-of-the-heart hybrid systems. First, the challenges, limitations, and benefits offered by multi-modality imaging systems are described and then, the most commonly used strategies, as well as novel techniques for image reconstruction and image corrections (attenuation, scattering, normalization, motion, and partial volume effect) are presented. The advantages and disadvantages of different methods are also discussed. We also briefly touch upon the factors that should be considered for reliable kinetic modeling and absolute quantitation in preclinical small animal research. Conclusions Multi-modality imaging has attracted a lot of research, particularly in the preclinical portfolio. Nevertheless, more research is still needed to optimize the conceptual design, reach the limits of quantitative imaging and implement standardized protocols for small-animal studies. Without any doubt, exploring the potential advantages of combined imaging units providing optimal image quality and reliable tools for quantification of biological parameters through standardized imaging protocols is one of the goals of translational research.

show abstract

Section: Normalizationmentioning

confidence: 99%

Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems

Amirrashedi

Zaidi

2020

Clin Transl Imaging

View full text Add to dashboard Cite

show abstract

The Historical Background of Quality Assurance at Laboratório de Imagem Molecular of the Centro de Desenvolvimento da Tecnologia Nuclear

Vilaça Silva,

Modesto Gadelha Gontijo,

Vidal Ferreira

2024

Braz. J. Rad. Sci.

View full text Add to dashboard Cite

The Centro de Desenvolvimento da Tecnologia Nuclear has a small animals positron emission tomograph in its Laboratório de Imagem Molecular. This equipment, the GE HealthCare LabPET SOLO 4 model, is widely used in preclinical studies related to the development of new radiopharmaceuticals or novel applications of conventional radiopharmaceuticals. The “PET Image Quality” subproject, integrated into the Centro de Desenvolvimento da Tecnologia Nuclear multi-year planning for 2018-2022, proposed actions involving quality assurance and human resources development for the laboratory. This work aims to consolidate the historical trajectory of Quality Assurance at Laboratório de Imagem Molecular of the Centro de Desenvolvimento da Tecnologia Nuclear. A search for documents related to the laboratory was conducted in the institutional quality system, called d-Qualidade, while a search for the curricula vitae of laboratory researchers was performed on the Plataforma Lattes, with the purpose of identifying the main products generated related to the Quality theme in the laboratory. The scientific production of the laboratory team demonstrates its pioneering role in Brazil in developing studies about the Quality Management applied to the small animals positron emission tomogragh. The laboratory history in the field of Quality Management emphasizes its national prominence and reveals the group's commitment over the past decade to significant technical/scientific production.

show abstract

Influence of detectors efficiency normalization on small animal PET image quality

Cited by 2 publications

References 2 publications

Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems

Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems

The Historical Background of Quality Assurance at Laboratório de Imagem Molecular of the Centro de Desenvolvimento da Tecnologia Nuclear

Contact Info

Product

Resources

About