Influence of depression on survival of colorectal cancer patients drawn from a large prospective cohort

Varela‐Moreno, Esperanza; Rivas‐Ruiz, Francisco; Padilla‐Ruiz, María; García, J. Alcaide; Zarcos‐Pedrinaci, Irene; Téllez, Teresa; Larrea‐Baz, Nerea Fernández‐de; Baré, Marisa; Bilbao, Amaia; Sarasqueta, Cristina; Morales-Suárez-Varela, María; Aguirre, Urko; Quintana, José María; Redondo, Maximino; Group, CARESS‐CCR Study

doi:10.1002/pon.6018

Cited by 8 publications

(2 citation statements)

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“…Higher levels of psychosocial distress have been found to be associated with significantly lower quality of life, higher morbidity and mortality ( Russ et al, 2012 ; Walker et al, 2020 , 2021 ; Varela-Moreno et al, 2022 ) and higher costs to the health system ( Chiu et al, 2017 ). Correlates of psychological distress and mental comorbidity in cancer populations include female gender, poor physical functioning that is often associated with advanced disease status and more invasive cancer treatments, less social support and socioeconomic status (SES), measured by education, income, and/or occupation ( Singer et al, 2013 ; Syrowatka et al, 2017 ; Sauer et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of mental disorders, psychosocial distress, and perceived need for psychosocial support in cancer patients and their relatives stratified by biopsychosocial factors: rationale, study design, and methods of a prospective multi-center observational cohort study (LUPE study)

et al. 2023

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BackgroundDespite remarkable progress, cancer remains a life-threatening disease for millions of people worldwide, also resulting in significant psychosocial limitations. High-quality, comprehensive cancer care requires patient and family involvement and the provision of needs-based, targeted psychosocial services. Although progress has been made in understanding the occurrence of mental comorbidity and psychosocial distress in cancer patients, comparatively little is known about the course of psychological comorbidity and psychosocial distress in early survivorship among patients and their families. We therefore aim to estimate the prevalence of mental disorders according to the DSM-5, psychosocial distress, perceived needs for psychosocial support and utilization of psychosocial support offers in newly diagnosed cancer patients and their relatives, taking into account potential contributing biopsychosocial factors for the occurrence of psychological comorbidity.Methods/designThis study follows a prospective multi-center observational cohort design across four measurement time points: within 2 months after cancer diagnosis (t1), and in the follow-up period at 6 months (t2), at 12 months (t3), and at 18 months (t4) after t1. Patients older than 18 years who have a confirmed initial diagnosis of a malignant solid tumor and are scheduled for cancer treatment at one of the participating cancer centers are eligible for study participation. Relatives of eligible patients are also eligible for study participation if they are older than 18 years. Patients are interviewed using the Structured Clinical Interview for DSM-5 Disorders (SCID-5-CV). In addition, patients and relatives receive a set of validated questionnaires at each measurement time point, covering comorbid conditions and functional performance, perceived psychological distress and quality of life, partnership aspects and social relationships, supportive care needs and use of psychosocial support services, health literacy, and health behavior and meaning in life.DiscussionThis prospective multi-center observational cohort study has a major focus on increasing quality of care and quality of life in cancer survivors through providing rigorous longitudinal data for the development and implementation of target group-specific psychosocial support services.Trial registrationNCT04620564, date of registration 9/11/2020; DKG OnkoZert: Registrier-No.: ST-U134, date of registration 5/11/2021.

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Section: Introductionmentioning

confidence: 99%

Prevalence of mental disorders, psychosocial distress, and perceived need for psychosocial support in cancer patients and their relatives stratified by biopsychosocial factors: rationale, study design, and methods of a prospective multi-center observational cohort study (LUPE study)

et al. 2023

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“…After identifying 2520 references, 575 duplicate publications and 1 876 unrelated studies were excluded, leaving 69 studies that potentially met the inclusion and exclusion criteria. Finally, 12 cohort studies conducted between 2013 and 2023 were included in this meta-analysis [ 2 , 11 – 17 , 21 – 24 ] (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data

Xia,

Zhu,

Luo

et al. 2024

Int J Colorectal Dis

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Background Depression and anxiety are common mental disorders in patients with colorectal cancer (CRC); however, it remains unclear whether they are related to cancer mortality. Method Based on a systematic literature search, 12 eligible studies involving 26,907 patients with CRC were included in this study. Results Univariate analysis revealed that anxiety was associated with an all-cause mortality rate of 1.42 (1.02, 1.96), whereas multivariate analysis revealed that anxiety was not associated with an all-cause mortality rate of 0.73 (0.39, 1.36). In univariate and multivariate analyses, depression was associated with all-cause mortality rates of 1.89 (1.68, 2.13) and 1.62 (1.27, 2.06), respectively, but not with the cancer-associated mortality rate of 1.16 (0.91, 1.48) in multivariate analyses. Multivariate subgroup analysis of depression and all-cause mortality showed that younger age (≤65 years), being diagnosed with depression/anxiety after a confirmed cancer diagnosis, and shorter follow-up time (<5 years) were associated with poor prognosis. Conclusions Our study emphasizes the key roles of depression and anxiety as independent factors for predicting the survival of patients with CRC. However, owing to the significant heterogeneity among the included studies, the results should be interpreted with caution. Early detection and effective treatment of depression and anxiety in patients with CRC have public health and clinical significance.

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Longitudinal trajectories of depression and quality of life in a cohort of cancer survivors and individuals without cancer in Europe

Baziliansky,

Holtmaat,

Erlich

et al. 2023

J Cancer Surviv

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Influence of depression on survival of colorectal cancer patients drawn from a large prospective cohort

Cited by 8 publications

References 50 publications

Prevalence of mental disorders, psychosocial distress, and perceived need for psychosocial support in cancer patients and their relatives stratified by biopsychosocial factors: rationale, study design, and methods of a prospective multi-center observational cohort study (LUPE study)

Prevalence of mental disorders, psychosocial distress, and perceived need for psychosocial support in cancer patients and their relatives stratified by biopsychosocial factors: rationale, study design, and methods of a prospective multi-center observational cohort study (LUPE study)

Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data

Longitudinal trajectories of depression and quality of life in a cohort of cancer survivors and individuals without cancer in Europe

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