Influence of dependent variables on granule formulation using factorial design: microwave irradiation as one of the factor

Abstract

As traditional drug delivery poses many disadvantages such as difficulty in consumption, the granules were opted to replace tablet dosage forms available in the market. A 23 full factorial design was employed for the formulation and characterization of the granule dosage form of oxcarbazepine. From regression equations we can assess the impact of each factor on the response further contour plots helped to pre-analyze the desired target factor values, in addition optimization process helped to analyze the values of dependent variables. Thus as of the results achieved a preferred response of flow property and drug release was obtained. In the current study, an attempt has been made to minimize possible number of experiments in the formulation of granule dosage forms. Polyvidone is a hydrophilic binder and primellose is a good disintegrate to obtain higher dissolution rate. A part, microwave assisted drying process plays a major role in achieving desired flow properties of granules.DOI: http://dx.doi.org/10.3329/icpj.v2i7.15153 International Current Pharmaceutical Journal, June 2013, 2(7): 115-118

Formulation, Optimization and Evaluation of Nutraceutical Effervescent Granules Containing Curcumin and Ascorbic Acid by Fusion Technique Using Full Factorial Design

“…Design of experiment (DoE) is an optimisation approach created for analysing all potentially significant variables simultaneously, systematically, and promptly for goods and/or processes 22 . This study's goal was to develop curcumin and ascorbic acid effervescent granules with excellent quality and more patient compliance using the Formulation by Design (FbD) methodology in a time and cost-effective manner 23,24 . To investigate the granules' physical and chemical properties, a 3 2 Full factorial design was employed.…”

Formulation and Evaluation of Aripiprazole Oro-Dispersible Tablets: Optimisation Through Factorial Design of Experiments

“…The independent variables studied were type of superdisintegrant, concentration of superdisintegrant, the chosen dependent variables or responses chosen was disintegration time. All analyses were performed using the Minitab 18 Software 10 . The detailed composition of the prepared ODTs is presented in Table 1.…”