Influence of Demographic, Surgical and Implant Variables on Wear Rate and Osteolysis in Abg I Hip Arthroplasty

Gallo, Jiří; Havranek,; Cechová, I; Zapletalová, Jana

doi:10.5507/bp.2006.021

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…OL and aseptic loosening pointed predominantly to accelerated wear rate 9 . It has been disclosed that PE liners made from GUR 415 resins and sterilized by gamma irradiation in air, can undergo signifi cant deterioration in their mechanical and chemical properties after longterm in vivo functioning 18 .…”

Section: Discussionmentioning

confidence: 99%

“…The reason for any revision was prospectively recorded and retrieved cups underwent detailed examination that included in vitro wear measurement using a Universal-type measuring microscope 9 . To exclude sepsis as a reason for failure, erythrocyte sedimentation rate, C-reactive protein, intra-operative cultures and histology for all revised hips were routinely investigated.…”

Section: Clinical and Radiographic Analysismentioning

confidence: 99%

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Poor Survival of Abg I Hip Prosthesis in Younger Patients

Gallo¹,

Langová²,

Havranek³

et al. 2008

BIOMED PAP

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Background: Hydroxyapatite coated (HAC) hip implants have been used in clinical practice for more than two decades. However, the majority of studies have reported only intermediate term outcomes that are not reliable for predicting long-term behavior in all implants. The aim of this study was to determine the performance of HAC total hip arthroplasty in younger patients over a 10-year follow-up period. Methods and Results:This was an observational retrospective study of a 137 consecutive hips with the ABG I prosthesis. Of these, 128 were available for the last investigation. Median duration of follow-up was 10.9 years. The mean age at time of index surgery was 46±6.7 years. Probability of implant survival was estimated using the Kaplan-Meier method. The overall 12-year cumulative survival was 0.55 (95% CI, 0.443-0.659). Periprosthetic osteolysis (57 %) was the most frequent reason for failure followed by aseptic loosening (28 %). When only aseptic loosening was included in the analysis, the same fi gures for cup and stem were 0.873 (95% CI, 0.808-0.938) and 0.992 (95% CI, 0.976-1.0), respectively. Patients with a smaller cup size were those at high risk for revision due to wear-related complications (odds ratio, OR=4.3; 95% CI, 1.734-10.555).Conclusion: This study reports one of the poorest 12-year survivorship data for cementless acetabular component in the literature. The main reason for premature failure was osteolysis, strongly related to high wear rate of polyethylene.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical and Radiographic Analysismentioning

confidence: 99%

Poor Survival of Abg I Hip Prosthesis in Younger Patients

Gallo¹,

Langová²,

Havranek³

et al. 2008

BIOMED PAP

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“…10 In contrast, however, there are many patients that escape the above-mentioned fate despite having the same type of THA with comparable alignment and physical activity. 21 In this line of thought, the key question is: How do these patients avoid developing periprosthetic osteolysis mechanically?…”

Section: Current Concept Of Periprosthetic Osteolysismentioning

confidence: 99%

Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

et al. 2012

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Numerous studies provide detailed insight into the triggering and amplification mechanisms of the inflammatory response associated with prosthetic wear particles, promoting final dominance of bone resorption over bone formation in multiple bone multicellular units around an implant. In fact, inflammation is a highly regulated process tightly linked to simultaneous stimulation of tissue protective and regenerative mechanisms in order to prevent collateral damage of periprosthetic tissues. A variety of cytokines, chemokines, hormones and specific cell populations, including macrophages, dendritic and stem cells, attempt to balance tissue architecture and minimize inflammation. Based on this fact, we postulate that the local tissue homeostatic mechanisms more effectively regulate the pro-inflammatory/pro-osteolytic cells/pathways in patients with none/mild periprosthetic osteolysis (PPOL) than in patients with severe PPOL. In this line of thinking, ‘particle disease theory’ can be understood, at least partially, in terms of the failure of local tissue homeostatic mechanisms. As a result, we envision focusing current research on homeostatic mechanisms in addition to traditional efforts to elucidate details of pro-inflammatory/pro-osteolytic pathways. We believe this approach could open new avenues for research and potential therapeutic strategies.

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“…In a previous study, we found a high risk for increased wear rate associated with this prosthesis [9]. Moreover, the univariate analyses revealed that wear rate was influenced by primary diagnosis, use of zirconia ceramic heads, medial cup settlement, and date of surgery.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for accelerated polyethylene wear and osteolysis in ABG I total hip arthroplasty

Gallo

Havranek

Zapletalová

2009

International Orthopaedics (SICOT)

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We analysed data from 155 revisions of identical cementless hip prostheses to determine the influence of patient-, implant-and surgery-related factors on the polyethylene wear rate and size of periprosthetic osteolysis (OL). This was calculated by logistic regression analysis. Factors associated with an increased/decreased wear rate included position of the cup relative to Kohler's line, increase in abduction angle of the cup, traumatic and inflammatory arthritis as a primary diagnosis, and patient height. Severe acetabular bone defects were predicted by an increased wear rate (odds ratio, OR=5.782 for wear rate above 200 mm 3 /y), and increased height of the patient (OR= 0.905 per each centimetre). Predictors of severe bone defects in the femur were the increased wear rate (OR=3.479 for wear rate above 200 mm 3 /y) and placement of the cup outside of the true acetabulum (OR=3.292). Variables related to surgical technique were the most predictive of polyethylene wear rate.

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Influence of Demographic, Surgical and Implant Variables on Wear Rate and Osteolysis in Abg I Hip Arthroplasty

Cited by 5 publications

References 32 publications

Poor Survival of Abg I Hip Prosthesis in Younger Patients

Poor Survival of Abg I Hip Prosthesis in Younger Patients

Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

Risk factors for accelerated polyethylene wear and osteolysis in ABG I total hip arthroplasty

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