Influence of delmopinol on bacterial ζ-potentials and on the colloidal stability of bacterial suspensions

Simonsson, Thomas; Arnebrant, Thomas; Petersson, Leif; Hvid, Eva Bondesson

doi:10.3109/00016359109005924

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…This finding is similar to the colloidal study that examined the influence of a cationic detergent on the stability of bacterial suspensions 23) . These findings strongly suggested that, because the chitosan used in this study carried positive charges, it functioned as a polycationic agent by adsorbing onto cell surfaces and by bridging together into aggregates to prevent adsorption of bacteria onto S-HA.…”

Section: Discussionsupporting

confidence: 84%

Effect of Molecular Mass and Degree of Deacetylation of Chitosan on Adsorption of Streptococcus sobrinus 6715 to Saliva Treated Hydroxyapatite.

Sano

Shibasaki

Mutoh

et al. 2002

Bull. Tokyo Dent. Coll.

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We evaluated the influence of molecular mass and degree of deacetylation of chitosan on the adsorption of Streptococcus sobrinus 6715 to saliva-treated hydroxyapatite (S-HA) by measuring the optical density of the bacterial cell suspensions released from saliva-treated hydroxyapatite. Twenty-five chitosan samples with different molecular masses (0.8-6 kDa) and degrees of deacetylation (10-95%) were prepared for the study. We found that the inhibition of adsorption of S. sobrinus 6715 to S-HA correlated positively with the molecular mass of chitosan (R‫)678.0ס‬ and that the optimal degree of deacetylation was 50-60% for maximum inhibition of bacterial binding to S-HA. We also examined the effect of chitosan on zeta potentials of the oral bacteria and their surface hydrophobicities. It was observed that chitosan reduced the magnitude of the zeta potential and surface hydrophobicities of the oral bacteria. Thus, the results demonstrated that chitosan with a molecular mass of 5-6 kDa and a degree of deacetylation of 50-60% might have the potential to act as an effective anti-plaque agent because of its polycationic properties.

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Section: Discussionsupporting

confidence: 84%

Effect of Molecular Mass and Degree of Deacetylation of Chitosan on Adsorption of Streptococcus sobrinus 6715 to Saliva Treated Hydroxyapatite.

Sano

Shibasaki

Mutoh

et al. 2002

Bull. Tokyo Dent. Coll.

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“…Although delmopinol apparently lacks a substantial antimicrobial effect, it has an effect on plaque and gingivitis (8). It has been suggested that delmopinol reduces the cohesive forces within dental plaque (29). It is probable that its physicochetnical properties play a significant role in its effect as a plaquecontrol agent (5).…”

Section: Supragingivai Piaque Compositionmentioning

confidence: 99%

Short‐term effect of topical application of delmopinol on salivary microbiology, plaque, and gingivitis

Collaert

Attström

Edwardsson

et al. 1994

European J Oral Sciences

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CoUaert B. Atlstrotn R. Edwardsson S. Hase JC. Astrimi M. Movert R: Shortterm effect qf topical application of deltnopinol on salivary microbiology, plaque, and gingivitis. Scatid J Denl Res 1994: 102: 17-25. © Munksgaard, 1994.The aim of this study was to test a possible dose-response effect of topical application of delmopinol HCl on the salivary microbiology, the healing of a pre-established experimental gingivitis, plaque development, and supragingival plaque composition. Forty-eight healthy suljjects were enrolled in an oral hygiene program for 2 wk to upgrade their oral health. After professional tooth cleaning, they abstained from all oral hygiene, but applied 2 ml of a placebo with a soft paintbrush onto their teeth twice daily for 2 wk. At the end of this period, the subjects received tooth cleaning and were then assigned to three treatment groups of 16 individuals each. They applied 2 ml of 0.1%, 0.5%, and 1% delmopinol HCl, respectively, twice daily for the next 2 wk and refrained from all other oral hygiene procedures. At the end of the placebo and delmopinol HCl treatment periods, (1) saliva samples were obtained and cultivated on a series of media, (2) the degree of gingivitis was measured with gingival crevicular fluid (GCF) and gingivitis index (GI), (3) the stainable buccal plaque extension was analyzed planimetrically, and (4) the bacterial inorphotypes of plaque adjacent to the gingival margin were analyzed. No changes in the salivary microbiologic counts were detected. The amounts of GCF and GI were reduced in all delmopinol groups, as compared with placebo. Mean plaque extension was reduced by 16% for the 0.1%), 56% for the 0.5%,, and 58% for the 1% delmopinol group. Cocci appeared to predominate in bacterial dental plaque when 0.5%) and V'/o delmopinol were used. The results indicate that short-term use of delmopinol promotes the healing of pre-established gingivitis, reduces plaque formation, and delays plaque maturation without detectable changes in the salivary microflora.

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“…Delmopinol is a tertiary amine surfactant, developed as an anti-plaque agent to reduce plaque and gingivitis as an adjunct to normal mechanical cleaning where this has proved inadequate. In opposite to some other anti-plaque chemicals, including chlorhexidine, which owe their effectiveness to a combination of bacteriostatic and bactericidal activity, delmopinol was developed to have comparably low antimicrobial properties, and by interfering with plaque matrix formation promote a microbial flora compatible with dental health [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Delmopinol Mouthwash on Aphthous Stomatitis

Sjödin¹,

Movert²,

Åström³

2022

JDHOR

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Objective: The purpose of this article was to perform a reanalysis of the adverse recordings from Phase III studies of Decapinol Mouthwash (containing 2 mg/mL of the active ingredient delmopinol HCl) on patients with gingivitis with respect to occurrence of aphthous stomatitis.Materials and Methods: The adverse events recordings from 8 randomized double-blind clinical studies on patients with gingivitis were statistically evaluated with respect to presence of aphthous stomatitis. The patients were treated for 2-6 months with mouthwashes containing delmopinol HCl 0.2%, delmopinol HCl 0.1%, chlorhexidine digluconate 0.2% or placebo. The number of visits in each study was three. Each time the patients visited the dentist for efficacy determinations, also data like adverse events were recorded. The number of patients with aphthous stomatitis at the different visits was calculated. Meta-analysis using the Fisher's exact test was performed to evaluate how the effect was related to the different treatments.Results: After 4-6 weeks, the patients rinsing with delmopinol HCl 0.2% was the only group showing a significantly better effect than the placebo group.

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Influence of delmopinol on bacterial ζ-potentials and on the colloidal stability of bacterial suspensions

Cited by 10 publications

References 8 publications

Effect of Molecular Mass and Degree of Deacetylation of Chitosan on Adsorption of Streptococcus sobrinus 6715 to Saliva Treated Hydroxyapatite.

Effect of Molecular Mass and Degree of Deacetylation of Chitosan on Adsorption of Streptococcus sobrinus 6715 to Saliva Treated Hydroxyapatite.

Short‐term effect of topical application of delmopinol on salivary microbiology, plaque, and gingivitis

The Effect of Delmopinol Mouthwash on Aphthous Stomatitis

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