1998
DOI: 10.5794/jjoms.44.941
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Influence of deacetylation of chitin on fibroblast-like cells and osteoblasts.

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Cited by 3 publications
(5 citation statements)
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“…For the culture time of 1 and 3 d, the optical density (OD) values of CHP were similar to that of CP. It has been stated that chitin is biocompatible and suitable for osteoblasts culture. , From the MTT results for 5 and 7 d, the cell viability increased obviously with the incorporation of HAP. HAP is one of the components of natural bone, so it is suitable for osteoblasts attachment and proliferation.…”
Section: Resultsmentioning
confidence: 99%
“…For the culture time of 1 and 3 d, the optical density (OD) values of CHP were similar to that of CP. It has been stated that chitin is biocompatible and suitable for osteoblasts culture. , From the MTT results for 5 and 7 d, the cell viability increased obviously with the incorporation of HAP. HAP is one of the components of natural bone, so it is suitable for osteoblasts attachment and proliferation.…”
Section: Resultsmentioning
confidence: 99%
“…Chitosan membranes (Kuo et al ., ), nanofibres (Shin et al ., ) and sponges (Seol et al ., ) have been used as scaffolds for bone formation. However, chitin and chitosan change their physical and biological properties according to their acetylation levels (Tominaga et al ., ). Mouse osteoblasts were cultured on sheets made of acetylated chitin and 35%, 50% and 70% deacetylated chitin (DAC‐0, DAC‐35, DAC‐50 and DAC‐70, respectively).…”
Section: Discussionmentioning
confidence: 97%
“…Mouse osteoblasts were cultured on sheets made of acetylated chitin and 35%, 50% and 70% deacetylated chitin (DAC‐0, DAC‐35, DAC‐50 and DAC‐70, respectively). The biocompatibility of DAC‐35 was the highest, and DAC‐70 suppressed cell growth and differentiation (Tominaga et al ., ). The DAC‐80 chitosan was used to prepare PCH in the present study, and it might suppress the growth and differentiation of osteoblasts.…”
Section: Discussionmentioning
confidence: 97%
“…Furthermore, chitosan membrane (10), nanofiber (11), and sponge (12) have been produced as tissue‐engineering scaffolds for bone formation. However, chitin (chitosan) changes its physical and biological properties according to its deacetylation level (13). When mouse osteoblast cells were cultured on sheets made of nondeacetylated chitin, and 35, 50, and 70% deacetylated chitin (DAC‐0, DAC‐35, DAC‐50, and DAC‐70, respectively), DAC‐35 had the highest effect of growth and differentiation of the cells, and DAC‐50 and DAC‐0 had intermediate effects, while DAC‐70 suppressed the growth and differentiation of the cells (13).…”
Section: Discussionmentioning
confidence: 99%
“…However, chitin (chitosan) changes its physical and biological properties according to its deacetylation level (13). When mouse osteoblast cells were cultured on sheets made of nondeacetylated chitin, and 35, 50, and 70% deacetylated chitin (DAC‐0, DAC‐35, DAC‐50, and DAC‐70, respectively), DAC‐35 had the highest effect of growth and differentiation of the cells, and DAC‐50 and DAC‐0 had intermediate effects, while DAC‐70 suppressed the growth and differentiation of the cells (13). In the present study, DAC‐80 chitin (chitosan) was used to prepare photocrosslinkable chitosan hydrogel.…”
Section: Discussionmentioning
confidence: 99%