Influence of Cytokines on Inflammatory Eye Diseases: A Citation Network Study

Abstract

Background: The main objective of this study was to use citation networks to analyze the relationship between different publications on the impact of cytokines at an ocular level and their authors. Furthermore, the different research areas will be identified, and the most cited publications determined. Methods: A search was performed in the Web of Science (WoS) database using the following keywords: “cytokine”, “inflammatory”, and “eye disease” for the period from 1990 to October 2021. The Citation Network Explorer and the CiteSpace software were then used to analyze the different publications. Results: 3127 publications with 8955 citations generated on the web were found. The largest number of publications on this topic emerged in 2018 and the authors with the largest number of publications addressing this area of research were Peizeng Yang (1.4%), Aize Kijlstra (1.3%), and Stephen C. Pflugfelder (1.2%). Conclusions: the citation network has provided a comprehensive and objective analysis of the main studies on the influence of cytokines in ocular inflammatory diseases.

The NK-1 Receptor Signaling: Distribution and Functional Relevance in the Eye

“…In fact, macrophages, dendritic cells, neutrophils, and lymphocytes all express the NK1R. Activation of this receptor promotes the production of pro-inflammatory cytokines, such as MIP-1B (macrophage inflammatory protein-1 beta), IL-6, TNF-α (tumor necrosis factor-α), and IL-8 from macrophages, dendritic cells, and lymphocytes [19,61,94]. Those cytokines have been described in ocular inflammation, including uveitis, glaucoma, retinal (macular) edema, and neovascularization.…”