Influence of cytokine gene variations on immunization to childhood vaccines

Yücesoy, Berran; Johnson, Victor J.; Fluharty, Kara; Kashon, Michael L.; Slaven, James E.; Wilson, Nevin W.; Weissman, David N.; Biagini, Raymond E.; Germolec, Dori R.; Luster, Michael I.

doi:10.1016/j.vaccine.2009.09.076

Cited by 56 publications

(41 citation statements)

References 48 publications

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“…We found in this study that neither gender nor viremia affected the YF-17D response. We cannot rule out the impact of polymorphisms in genes involved in cytokines or HLA molecules in the vaccine response (36)(37)(38)(39). Studies with greater numbers of volunteers would be required to address their effect on the YF-17D response.…”

Section: Discussionmentioning

confidence: 99%

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

et al. 2014

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Background. Defining the parameters that modulate vaccine responses in African populations will be imperative to design effective vaccines for protection against HIV, malaria, tuberculosis, and dengue virus infections. This study aimed to evaluate the contribution of the patient-specific immune microenvironment to the response to the licensed yellow fever vaccine 17D (YF-17D) in an African cohort. Conclusion.Together, these results demonstrate that an activated immune microenvironment prior to vaccination impedes efficacy of the YF-17D vaccine in an African cohort and suggest that vaccine regimens may need to be boosted in African populations to achieve efficient immunity.Trial registration. Registration is not required for observational studies.

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Section: Discussionmentioning

confidence: 99%

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

et al. 2014

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“…Additionally, immunogenetic studies have also shown associations between polymorphisms in gene-encoding immune response proteins and variation in response to vaccines. Among others, associations between an SNP in the forkhead box protein 1 (FOXP1) gene, a transcription factor regulating B cell development (25) and in various cytokine genes, such as gamma interferon (IFN-␥), IL-4, IL-4R, IL-10, IL-10RA, IL-12B, and tumor necrosis factor (TNF), and the vaccine efficacy have also been shown (26,27). Another proposed inhibitory mechanism that may contribute to inadequate infant response to vaccine is related to high titers of maternal antibodies that persist over a period of 6 to 12 months.…”

Section: Discussionmentioning

confidence: 99%

Impaired Antigen-Specific Immune Response to Vaccines in Children with Antibody Production Defects

Szczawińska-Popłonyk

Bręborowicz

Samara

et al. 2015

Clin Vaccine Immunol

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The impaired synthesis of antigen-specific antibodies, which is indispensable for an adaptive immune response to infections, is a fundamental pathomechanism that leads to clinical manifestations in children with antibody production defects. The aim of this study was to evaluate the synthesis of antigen-specific antibodies following immunization in relation to peripheral blood B cell subsets in young children with hypogammaglobulinemia. Twenty-two children, aged from 8 to 61 months, with a deficiency in one or more major immunoglobulin classes participated in the study. Postvaccination antibodies against tetanus and diphtheria toxoids, the surface antigen of the hepatitis B virus, and the capsular Haemophilus influenzae type b polysaccharide antigen were assessed along with an immunophenotypic evaluation of peripheral blood B lymph cell maturation. A deficiency of antibodies against the tetanus toxoid was assessed in 73% of cases and that against the diphtheria toxoid was assessed in 68% of cases, whereas a deficiency of antibodies against the surface antigen of the hepatitis B virus was revealed in 59% of the children included in the study. A defective response to immunization with a conjugate vaccine with the Haemophilus influenzae type b polysaccharide antigen was demonstrated in 55% of hypogammaglobulinemic patients. Increased proportions of transitional B lymph cells and an accumulation of plasmablasts accompanied antibody deficiencies. The defective response to vaccine protein and polysaccharide antigens is a predominating disorder of humoral immunity in children with hypogammaglobulinemia and may result from a dysfunctional state of the cellular elements of the immune system. A ntibody production defects are the most common category of pediatric primary immunodeficiencies (PIDs) (1, 2). The hallmark of these immunodeficiency conditions is the defective production of antigen-specific antibodies that are an indispensable element of the adaptive immune response to pathogens (3, 4). While the poor response to vaccines is another feature of humoral PIDs, the ability to synthesize postvaccination antibodies against toxoids and polysaccharides is the most specific expression of the immune response to antigens. In the evaluation of the immune response associated with antibody production, the response to vaccination against hepatitis B is not routinely recommended because of the large proportion of adults, up to between 1% and 3% of vaccinated individuals, who do not effectively synthesize antibodies against hepatitis B virus surface antigen (HBs). In infants and children, the efficiency of recombinant vaccines against hepatitis B, assessed on the basis of postvaccination anti-HBs antibody concentration over 10 mIU/ml, is estimated at 85% to 100% (5, 6). The minimal protective level of neutralizing antibodies against diphtheria and tetanus toxoids has been estimated at 0.01 to 0.1 IU/ml, whereas to achieve long-term immunity, a concentration of specific antibodies, up to 1.0 IU/ml, may be required. The synthesis of...

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“…[137] Shah echoed comments by Allen Roses, then-worldwide vice-president of genetics at GlaxoSmithKline (GSK), who stated that fewer than half of the patients prescribed some of the most expensive drugs derived any benefit from them: "The vast majority of drugs -more than 90% -only work in 30 or 50% of the people." [138] That individual humans respond very differently to disease and drugs [139,140], including vaccines [141,142], has long been appreciated. During the Korean War, Alving observed that black soldiers had an increased probability, compared with white soldiers, of developing anemia when from antimalarials.…”

Section: Twenty-first Century Sciencementioning

confidence: 99%

Animal Models in Drug Development

Greek¹

2013

New Insights Into Toxicity and Drug Testing

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Influence of cytokine gene variations on immunization to childhood vaccines

Cited by 56 publications

References 48 publications

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

Impaired Antigen-Specific Immune Response to Vaccines in Children with Antibody Production Defects

Animal Models in Drug Development

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