Influence of CYP1A1*2C on High Triglyceride Levels in Female Mexican Indigenous Tarahumaras

Bailón-Soto, Claudia E.; Galavíz-Hernández, Carlos; Lazalde-Ramos, Blanca Patricia; Hernández-Velázquez, Daniel; Salas-Pacheco, José M.; Lares-Assef, Ismael; Sosa-Macías, Martha

doi:10.1016/j.arcmed.2014.05.007

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…In a Mexican study, CYP1A1-m2 allele was significantly associated with high triglycerides (28), and in a Brazilian study in postmenopausal women the same allele was associated with high HDL-cholesterol (29). Unlike these studies, we have found no association between any of the CYP1A1 polymorphisms and lipid parameters and neither has a Japanese study in women with osteopenia or osteoporosis (30).…”

Section: Discussioncontrasting

confidence: 47%

Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant

Pašalić

Marinković²

2017

Archives of Industrial Hygiene and Toxicology

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The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Fasting serum concentrations of biochemical parameters were determined with standard methods. Genetic polymorphisms of CYP 1A1 rs4646903, rs1048943, rs4986883, and rs1799814 were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFPL), while GSTM1 and GSTT1 deletions were detected with multiplex PCR. Cardiovascular risk was assessed with Framingham risk score, and the subjects divided in two groups: >10% risk and ≤10% risk. The two groups did not differ in the genotype frequencies. MANCOVA analysis, which included lipid parameters, glucose, and BMI with sex, age, hypertension and smoking status as covariates, showed a significant difference between the GSTT1*0 and GSTT1*1 allele carriers (p=0.001). UNIANCOVA with same covariates showed that total cholesterol and triglyceride levels were significantly higher in GSTT1*1 allele carriers than in GSTT1*0 carriers (p<0.001 and p=0.006, respectively). Our findings suggest that CYP1A1, GSTM1, and GSTT1 polymorphisms are not associated with the higher risk of CAD, but that GSTT1 affects lipid profile.

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Section: Discussioncontrasting

confidence: 47%

Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant

Pašalić

Marinković²

2017

Archives of Industrial Hygiene and Toxicology

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“…The CYP1F2*1F was found to be more frequent in Mexican Amerindians than Mestizos in a Mexican study [154], while differences in frequency were also reported among ethnic groups in Singapore [155], between Taiwanese, Caucasians and African Americans [156], while Ethiopians appeared to display at least twice the variations found in all other populations combined. A significant association between CYP1A*2c and triglyceride level has been described in Mexican Amerindian Tarahumaras compared to the Tepehuanos [157,158]. It has also been suggested that CYP1A1*3 may be specific for individuals of African descent, while the CYP1A1*2 is closely linked to Asian ethnicity but less so to Caucasian [159].…”

Section: Impact Of Ethnicity On the Role Of Genetic Variations In Antmentioning

confidence: 99%

Ethnicity and Response to Drug Therapy

Al‐Rasheed¹,

Dzimiri²

2016

Cholesterol Lowering Therapies and Drugs

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Hypercholesterolemia is a complex disorder presenting in different forms, including the familial form (FH), with varying underlying aetiology, and contributing substantially to coronary artery disease. Particularly, the FH underlies monogenic changes in genes involved in cholesterol synthesis and transport, including the low density lipoprotein receptor, proprotein convertase sublitisin/kexin type 9 and apolipoprotein B. However, hyperlipidemia is largely a complex interaction of changes in multiple genes with environmental factors, such as diet, overweight and obesity that are controllable by adopting healthy eating habits and exercise, which may vary by ethnicity. Diet alone is often not adequate to achieve the desired lipid lowering effect in individuals harbouring very high cholesterol levels, necessitating the use of lipid lowering medication or other forms of therapy. Antilipidemic drugs fall into (a) bile acid sequestrants (b) cholesterol absorption inhibitors, (c) 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, (d) fibric acid derivatives (e) proprotein convertase subtilisin/kexin type 9 inhibitors, (f) miscellaneous agents and (g) drug combinations. Mutations in their various metabolizing enzymes, particularly the cytochrome P450 family, often lead to partially/non-functional, or even rapid metabolizing phenotypes, triggering great variations in the way individuals respond to drug therapy, which in turn depends on ethnicity. This may produce unexpected outcomes such as therapeutic failure, adverse side effects and toxicity in individuals of different ethnic origin. Hence, in-depth information of the impact of ethnicity on these relationships has the huge potential of achieving optimal quality use of drugs as well as improving the efficacy and safety of antilipidemic therapeutic agents.

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Transcriptome analysis of adipose tissue from pigs divergent in feed efficiency reveals alteration in gene networks related to adipose growth, lipid metabolism, extracellular matrix, and immune response

et al. 2018

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Influence of CYP1A1*2C on High Triglyceride Levels in Female Mexican Indigenous Tarahumaras

Cited by 5 publications

References 37 publications

Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant

Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant

Ethnicity and Response to Drug Therapy

Transcriptome analysis of adipose tissue from pigs divergent in feed efficiency reveals alteration in gene networks related to adipose growth, lipid metabolism, extracellular matrix, and immune response

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