Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature

Barros-Oliveira, Maria da Conceição; Costa‐Silva, Danylo Rafhael; Santos, Adaniel Sousa dos; Pereira, Renato Oliveira; Soares-Júnior, José Maria; Silva, Benedito Borges da

doi:10.6061/clinics/2021/e2846

Cited by 10 publications

(3 citation statements)

References 53 publications

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“…Thus, the expression of CYPs in tumor cells may play an important role in antitumor therapy. Of note, it was shown that the expression of CYPs in tumor cells was usually aberrant, compared with adjacent normal tissues [ 23 ]. The low expression and activity of CYPs, partly owing to distinctive metabolic reprogramming and living conditions, may reduce the activation of antitumor agents in tumor cells, whilst the overexpression of CYPs in tumor cells may rapidly devitalize tumor agent substrates, which may be associated with treatment resistance and cause subsequent tumor relapse and poor prognosis [ 24 , 25 ].…”

Section: Human Cypsmentioning

confidence: 99%

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Zhao

Ma²,

et al. 2021

IJMS

210

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Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination of common clinical drugs can be attributed to one or more of the various CYPs, from the CYP families 1–3. In addition to the basic metabolic effects for elimination, CYPs are also capable of affecting drug responses by influencing drug action, safety, bioavailability, and drug resistance through metabolism, in both metabolic organs and local sites of action. Structures of CYPs have recently provided new insights into both understanding the mechanisms of drug metabolism and exploiting CYPs as drug targets. Genetic polymorphisms and epigenetic changes in CYP genes and environmental factors may be responsible for interethnic and interindividual variations in the therapeutic efficacy of drugs. In this review, we summarize and highlight the structural knowledge about CYPs and the major CYPs in drug metabolism. Additionally, genetic and epigenetic factors, as well as several intrinsic and extrinsic factors that contribute to interindividual variation in drug response are also reviewed, to reveal the multifarious and important roles of CYP-mediated metabolism and elimination in drug therapy.

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Section: Human Cypsmentioning

confidence: 99%

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Zhao

Ma²,

et al. 2021

IJMS

210

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“…CYP19A1 encodes for the aromatase enzyme, which plays an essential role in estrogen biosynthesis by chemically aromatizing androgens to estrogen (this conversion is tightly regulated, and any dysfunction is related to a range of disorders—breast cancer and polycystic ovary syndrome, to name a few) [ 43 , 227 ].…”

Section: Current Challenges With Lipedemamentioning

confidence: 99%

Lipedema: Insights into Morphology, Pathophysiology, and Challenges

2022

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Lipedema is an adipofascial disorder that almost exclusively affects women. Lipedema leads to chronic pain, swelling, and other discomforts due to the bilateral and asymmetrical expansion of subcutaneous adipose tissue. Although various distinctive morphological characteristics, such as the hyperproliferation of fat cells, fibrosis, and inflammation, have been characterized in the progression of lipedema, the mechanisms underlying these changes have not yet been fully investigated. In addition, it is challenging to reduce the excessive fat in lipedema patients using conventional weight-loss techniques, such as lifestyle (diet and exercise) changes, bariatric surgery, and pharmacological interventions. Therefore, lipedema patients also go through additional psychosocial distress in the absence of permanent treatment. Research to understand the pathology of lipedema is still in its infancy, but promising markers derived from exosome, cytokine, lipidomic, and metabolomic profiling studies suggest a condition distinct from obesity and lymphedema. Although genetics seems to be a substantial cause of lipedema, due to the small number of patients involved in such studies, the extrapolation of data at a broader scale is challenging. With the current lack of etiology-guided treatments for lipedema, the discovery of new promising biomarkers could provide potential solutions to combat this complex disease. This review aims to address the morphological phenotype of lipedema fat, as well as its unclear pathophysiology, with a primary emphasis on excessive interstitial fluid, extracellular matrix remodeling, and lymphatic and vasculature dysfunction. The potential mechanisms, genetic implications, and proposed biomarkers for lipedema are further discussed in detail. Finally, we mention the challenges related to lipedema and emphasize the prospects of technological interventions to benefit the lipedema community in the future.

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“…4 Traditionally, high body mass index (BMI), advanced age, as well as high plasma glucose and alcohol consumption were considered to be related to the etiology of BRC. 5,6 In addition, similar to other cancers, the etiology of BRC was closely related to the aberrant expression of multiple genes, both coding 7,8 and non-coding. 9,10 Recently, the role of non-coding gene expression, in particular microRNAs (miRs), in the occurrence of BRC has gradually become a focus of research into the etiology of BRC.…”

Section: Introductionmentioning

confidence: 99%

Decreased miR-127 promotes the occurrence of breast cancer via increasing the expression of SPP1

Wei¹,

Tan²,

Wang³

et al. 2023

Adv Clin Exp Med

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Background. The expression of miR-127 has been reported to be decreased in the breast tissue of patients with breast cancer (BRC). However, the mechanism of miR-127 involvement in the pathogenesis of BRC is still unclear and requires urgent clarification.Objectives. To explore the role of miR-127 in the pathogenesis of BRC. Materials and methods.In this study, we measured the expression of miR-127 in blood samples of 60 BRC patients and 60 controls, investigated the influence of miR-127 on the viability and apoptosis of MCF-7 and MDA-231 cells, identified a miR-127 target gene, and determined the expression level of the target gene in the blood samples of BRC patients and controls.Results. We found that miR-127 expression was significantly decreased in the plasma of BRC patients compared to controls. Additionally, the upregulation of miR-127 in MCF-7 and MDA-231 cells inhibited their proliferation and promoted their apoptosis. Conversely, the downregulation of miR-127 promoted cell proliferation and inhibited their apoptosis. The SPP1 was successively predicted and validated as a target gene of miR-127. Finally, the expression level of SPP1 was significantly increased in the plasma of BRC patients compared to controls. Conclusions.Our study demonstrated that decreased miR-127 may promote BRC cell proliferation, inhibit apoptosis and promote the occurrence of BRC through increasing the SPP1 expression level.

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Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature

Cited by 10 publications

References 53 publications

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Lipedema: Insights into Morphology, Pathophysiology, and Challenges

Decreased miR-127 promotes the occurrence of breast cancer via increasing the expression of SPP1

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