Influence of cyclopropene fatty acids (Baobab seed oil) feeding on the in vitro Δ9 desaturation of stearic acid in rat liver microsomes

Effects of Cyclopropenoid Fatty Acids (Baobab Seed Oil) on the Fatty Acid Profile of Lipids From Different Tissues in the Rat

“…Previous results on in vifro desaturation have clearly shown that A9 desaturation of stearic acid, A6 desaturation of linolenic acid and A5 desaturation of Table 2. dihomo-y-linolenic acid were inhibited in liver microsomes in rats fed on fresh Baobab seed oil (Andrianaivo et al 1993;Cao et al 1993). Inhibition of A9 and A6 desaturation was ca 50%, and that of A5 desaturation was ca 20%.…”

“…Cyclopropenoid fatty acids, particularly sterculic acid, inhibited A9 desaturation of stearic acid into oleic acid in several animal species (Johnson ef al. 1%9;Roehm et al 1970;Pande and Mead 1970;Jeffcoat and Pollard 1972;Andrianaivo et al 1993) and in plants (James et al 1968). Only recently it has been shown that the two cyclopropenoid fatty acids also inhibit A6 desaturation of linoleic acid into y-linolenic acid and A5 desaturation of dihomoy-linolenic acid into arachidonic acid, in rat liver microsomes (Cao ef al.…”

Evidence for marsh mallow (Malva parviflora) toxicosis causing myocardial disease and myopathy in four horses

“…The cyclopropene ring is destroyed during hydrogenation in the refining process of seed oils from plants of the order Malvales . This change is thought to negate the toxicity caused by unrefined oils such as cottonseed oil . Further, cyclopropane fatty acids do not appear to cause any of the metabolic changes reported for cyclopropene fatty acids in rats .…”

“…In sheep fed M. parviflora, those that showed signs of toxicosis were in negative energy balance [3], while wellfed sheep were unaffected [36]. Similarly, administration of cyclopropene fatty acids to rats, chickens and dairy cows in a neutral or positive energy balance did not induce toxicosis, but rather caused changes in composition of body, egg and milk fats [14,[17][18][19][20][21]. During negative energy balance, flux through b-oxidation pathways is greatly increased.…”

Potential of Unconventional Seed Oils and Fats from West African Trees: A Review of Fatty Acid Composition and Perspectives

“…It is reported to have high oxidation stability (Babiker et al, 2017). Cyclopropene and cyclopropane FA, which is found in several species from the Malvaceae family (see below), were not reported in the studies included in this review, although it has earlier been reported (Andrianaivo-Rafehivola et al, 1993;Ralaimanarivo et al, 1982), however, in the latter case the oil could be from a different Adansonia species, as this was not specified.…”