Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state

Glass, Beverley; Brown, Michael E.; Daya, Santy; Worthington, M. S.; Drummond, P.; Antunes, Edith; Lebete, M.; Anoopkumar‐Dukie, Shailendra; Maharaj, Dale

doi:10.1155/s1110662x01000277

Cited by 22 publications

(26 citation statements)

References 15 publications

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“…Finally, TBPs 1, 2, 13 and 14 are detected only in samples after 240 min of treatment and at low concentration levels and thus they can be considered as later stage products. For the sake of comparison with other studies dealing with the degradation of PRX, TBP 14 and structurally similar TBPs have been identified as degradation products of PRX under oxidative and photolytic conditions . In addition, the in vivo formation of the metabolic oxidation product 5‐hydroxypiroxicam and at least 13 new secondary peaks (without structure identification) after the in vitro study of hydroxyl radical attack of PRX was reported elsewhere …”

Section: Resultsmentioning

confidence: 94%

Sonochemical oxidation of piroxicam drug: effect of key operating parameters and degradation pathways

Lianou

Frontistis

Chatzisymeon

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND Piroxicam (PRX) is a non‐steroidal anti‐inflammatory drug (NSAID) commonly used to relieve pain and swelling of conditions like arthritis. PRX has been extensively detected in seawater, surface, and sewage waters worldwide and therefore its efficient treatment is an issue of emerging concern. In this work, the sonochemical degradation of PRX was investigated. RESULTS All experiments were conducted at constant ultrasound frequency of 20 kHz while the following range of experimental conditions was investigated: initial PRX concentration 320–960 µg L‐1, ultrasound power density 20–60 W L‐1, temperature 20–60 °C, reaction time up to 60 min. The effect of different water matrices, namely surface water (SW), bottled water (BW), ultrapure water (UPW) and humic acid (HA) aqueous solution on process efficiency was also explored. It was found that PRX degradation reached 96% after only 10 min of treatment under the best conditions (i.e. [PRX]0 = 320 mg L‐1, 20 °C, 36 W L‐1) assayed. Power density could positively affect PRX degradation. Nevertheless, PRX degradation decreased when its initial concentration and the temperature of the bulk liquid was increased. PRX degradation was found to decrease, in different water matrices, in the order: UPW > 5 mg L‐1 HA > BW > 10 mg L‐1 HA > SW. High resolution mass spectrometry analysis revealed that 14 transformation by‐products (TBPs) were formed and subsequently degraded during treatment while the PRX degradation pathways were also elucidated. CONCLUSION At the optimal operating conditions assayed, PRX was efficiently degraded after about 10 min of sonochemical oxidation, thus rendering it a promising technology for the treatment of xenobiotics. © 2017 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 94%

Sonochemical oxidation of piroxicam drug: effect of key operating parameters and degradation pathways

Lianou

Frontistis

Chatzisymeon

et al. 2017

J of Chemical Tech & Biotech

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“…Complexation can also affect photoreactivity, and the use of cyclodextrins has been shown to promote, reduce, or have no effect on photostability [6]. Since photochemical reactions often lead to oxidative degradation, an inert atmosphere, chelating agents, and antioxidants can be used together.…”

Section: Photolysismentioning

confidence: 99%

“…Diclofenac is known to undergo photodegradation at the chlorine atoms, but this can be retarded by complexing the drug substance with 2-hydroxypropyl-β-cyclodextrin ( Figure 32.4) [6]. Diclofenac is known to undergo photodegradation at the chlorine atoms, but this can be retarded by complexing the drug substance with 2-hydroxypropyl-β-cyclodextrin ( Figure 32.4) [6].…”

Section: Photolysismentioning

confidence: 99%

Chemical and Physicochemical Approaches to Solve Formulation Problems

Lieberman

Vemuri

2015

The Practice of Medicinal Chemistry

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“…Photostability of nifidipine and chlorpromazine hydrochloride is increased when incorporated in cyclodextrin cavity. [26,27] …”

Section: Drug-matrix Interactionsmentioning

confidence: 99%

A basic insight into the stability and manufacturing aspects of solid dispersions

2012

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The development of a bioavailable dosage form is the most challenging task for the researchers. In the arena of advanced drug delivery systems, the solid dispersion techniques seem to be a promising system for the development of an optimized, bioavailable formulation of Class 2 drugs. The methods of formulation of solid dispersion have been summarized. This article is an effort to define a solid dispersion and its classification. The prospective of the stability of solid dispersion has also been discussed. Moreover, the major techniques that have been used so far such as the fusion/melting method, solvent evaporation method, hot melt extrusion method, supercritical fluid methods, have also been detailed.

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Influence of cyclodextrins on the photostability of selected drug molecules in solution and the solid-state

Cited by 22 publications

References 15 publications

Sonochemical oxidation of piroxicam drug: effect of key operating parameters and degradation pathways

Sonochemical oxidation of piroxicam drug: effect of key operating parameters and degradation pathways

Chemical and Physicochemical Approaches to Solve Formulation Problems

A basic insight into the stability and manufacturing aspects of solid dispersions

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