Influence of Curcumin Supplementation on Exercise-Induced Oxidative Stress

Abstract

Background: Polyphenols are a class of organic chemical compounds, with strong antioxidant capacity. This investigation evaluates the influences of one week curcumin supplementation on selected indices of oxidative stress after 14 km running in active healthy young males. Objectives: The aim of this study was to investigate the effects of 1 week of curcumin supplementation on anti-oxidant markers. Methods: Subjects were randomized in a double blind, placebo-controlled fashion into two groups: Curcumin (C) (n = 11) and placebo (P) (n = 9). The subjects received supplementation (90 mg) or placebo for 7 days before main trial. Then, subjects ran 14 km. Total antioxidant capacity (TAC), reduced glutathione (GSH), and malondialdehyde (MDA-TBARS) were measured using spectrophotometer methods. Results: There was a significant increase in TAC after supplementation (P < 0.001, ES = 1. 42), and immediately after exercise (P = 0. 008, ES = 1. 12) in C group compared with the P group. MDA-TBARS was significantly lower in C group compared with the P group immediately after exercise (P = 0. 022, ES = 1. 00). GSH significantly increased immediately, 24, and 48 hours after exercise compared with pre-exercise only in C group (P < 0.05). Conclusions: It is concluded one week oral supplementation of curcumin has positive effects on selected indices of oxidative stress possibly via promotion of antioxidant capacity.

Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials

“…Qin et al 2018 [ 159 ] observed a significant reduction in MDA levels (SMD = −0.769; 95% CI −1.059 to −0.478) in seven publications [ 27 , 57 , 98 , 114 , 124 , 153 , 156 ]. Alizadeh et al 2019 [ 150 ] showed a significant reduction in MDA (SMD = −0.46; 95% CI −0.68 to −0.25) in 12 publications [ 27 , 43 , 98 , 124 , 143 , 151 , 152 , 153 , 154 , 155 , 156 , 157 ].…”

Melatonin, the advance-guard in oxidative myocardial assault instigated by exercise stress: a physiological and biochemical insight

“…At moderate concentrations, it displays significant antioxidant and anti-inflammatory property (97,98). Studies have demonstrated that curcumin potentially reduces serum lipid peroxidation level and restore normal serum reduced glutathione (GSH) content in subjects participating in intense running (99). Curcumin reduces inflammatory reaction in mice performing full-body exercise (100), improves the antioxidant status in humans participating in exercise (101) and decreases muscle soreness and damage in participants performing moderate to high-intensity aerobic exercises (102).…”

Effects of Beetroot Supplementation on Recovery After Exercise-Induced Muscle Damage: A Systematic Review

“…52 Some studies have suggested that betalains have potential antioxidant and anti-inflammatory effects 23,55 and supplementation with beetroot has been proposed not only to improve exercise performance but also to protect against oxidative stress. 39 The betalains, and betanins in particular, are thought to be the most potent antioxidant molecules and have shown to attenuate ROS production and to stimulate the expression of antioxidant enzyme genes. 18 Specific interest in beetroots has arisen in the last years because it is a rich source of polyphenolic compounds and NO 3 -.…”

“…18 Specific interest in beetroots has arisen in the last years because it is a rich source of polyphenolic compounds and NO 3 -. 39 Since NO 3 may serve as a precursor of NO, supplementation with beetroots could have beneficial effects on sports performance. 54 Furthermore, because of the potential involvement of NO in the damage and repair processes in skeletal muscle, it has been suggested that beetroot supplementation could enhance recovery after EIMD.…”

“…19,31,45 Another natural product that is frequently used is curcumin, the main bioactive polyphenol of the spice herb turmeric, which possesses anti-inflammatory and antioxidant qualities. 39 Supplementation with curcumin has been associated with faster muscle recovery and reduction of inflammation and oxidative stress. 19 Consumption of nitrate-rich (NO 3 -) vegetables has also been proposed for enhancement of cardiovascular function.…”