Influence of curcuma (Curcuma xanthorrhiza Roxb) on lipid metabolism in rabbits

Abstract

The efficacy of curcuma (Curcuma xanthorrhiza) in lowering blood plasma lipid was evaluated in rabbits. Forty male New Zealand white rabbits (2.3 kg) were divided into four equal groups and offered isoatherogenic diets with no curcuma, low curcuma (2 g kg À1 ), medium curcuma (3 g kg À1 ) and high curcuma (4 g kg À1 ) for 120 days. Faeces and feed samples were collected. Body weight was measured weekly. Blood samples at 1, 2 and 4 months and liver samples at the last blood collection were taken. Curcuma did not influence feed, protein and fat consumption and protein excretion (P > 0.05) but significantly (P < 0.05) increased fat excretion. Cholesterol concentration was decreased by 46.6, 56.4 and 63.2% and HDL concentration was decreased by 9.9, 14.5 and 21.9% at 2, 3 and 4 g kg À1 curcuma respectively. Curcuma significantly (P < 0.05) decreased LDL concentration and significantly (P < 0.01) decreased triglyceride concentration by 20.4, 28.5 and 29.5% at 2, 3 and 4 g kg À1 respectively. HMG-CoA reductase inhibitor was significantly (P < 0.05) increased by curcuma. Glucose was significantly (P < 0.05) reduced by 6.2, 7.6 and 18.0% at 2, 3 and 4 g kg À1 curcuma respectively. Lipid peroxidation was prevented at 3 and 4 g kg À1 curcuma. The enhanced fat excretion could have been mediated through an acceleration of lipid metabolism from extrahepatic tissues to the liver, which would increase the excretion of cholesterol via the bile and into the faeces. Since this is central to lipid metabolism, curcuma has potential as a phytotherapeutic agent under atherosclerosis and cardiovascular disease conditions.

Effect of Dietary Supplementation of Cinnamon and Curcumin on Performance, Carcass Traits, Humoral Immune Responses, and Blood Serummetabolites in Growing Rabbits

“…On the other hand, Lee et al (2003) failed to show any hypocholesterolemic effects of the active items as cinnamaldehyde. Wientarsih et al (2002) reported that Curcuma longa supplementation to the rabbit diets significantly decreased LDL, total cholesterol and triglycerides concentrations in plasma. Where, inclusion of Curcuma longa in the rabbit diets led to an increase in the 3-hydroxy-3-methylglutaryl coenzyme reductase inhibitor activity (Wientarsih et al, 2002); thereby, the reduction of 3hydroxy-3-methylglutaryl coenzyme reductase resulted in a decrease in total cholesterol biosynthesis in rat cells (Amin et al, 1993).…”

“…Wientarsih et al (2002) reported that Curcuma longa supplementation to the rabbit diets significantly decreased LDL, total cholesterol and triglycerides concentrations in plasma. Where, inclusion of Curcuma longa in the rabbit diets led to an increase in the 3-hydroxy-3-methylglutaryl coenzyme reductase inhibitor activity (Wientarsih et al, 2002); thereby, the reduction of 3hydroxy-3-methylglutaryl coenzyme reductase resulted in a decrease in total cholesterol biosynthesis in rat cells (Amin et al, 1993). The obtained results were in agreement with Alagawany et al (2016) who found that triglycerides, total cholesterol and low density lipoprotein concentrations were linearly and quadratically decreased with increasing the dietary proportion of turmeric.…”

Effects of replacing palm oil with maize oil and Curcuma longa supplementation on the performance, carcass characteristics, meat quality and fatty acid profile of the perirenal fat and muscle of growing rabbits

“…In rabbit mixed feeds with palm oil (PO) supplementation, CL has decreased acid detergent fibre (ADF) digestibility and increased ether extract (EE) digestibility. The use of curcuma in rabbit diets has been evaluated, because of its effects on lipid metabolism, by Wientarsih et al (2002), who observed enhanced fat and cholesterol excretion mediated through an acceleration of the lipid metabolism from the extrahepatic tissues to the liver.…”

“…According to Rise et al (2003), it totally inhibits the D6 and D5 desaturation steps, preserves the level of ALA, and decreases cholesterol synthesis. In a prolonged administration to rabbits, Wientarsih et al (2002) have observed that Curcuma xanthorrhiza significantly decreases LDL and triglyceride concentrations. Curcuma inclusion has led to an increase in the 3-hydroxy-3-methylglutaryl coenzyme (HMGCoA) reductase inhibitor activity (Wientarsih et al, 2002) and the inhibition of HMG-CoA reductase resulted in a decrease in cholesterol synthesis in rat cells (Amin et al, 1993).…”

“…In a prolonged administration to rabbits, Wientarsih et al (2002) have observed that Curcuma xanthorrhiza significantly decreases LDL and triglyceride concentrations. Curcuma inclusion has led to an increase in the 3-hydroxy-3-methylglutaryl coenzyme (HMGCoA) reductase inhibitor activity (Wientarsih et al, 2002) and the inhibition of HMG-CoA reductase resulted in a decrease in cholesterol synthesis in rat cells (Amin et al, 1993). The critical enzymes for producing PA, C18:0 and OA to maintain homoeostasis, are FA synthase, elongase and desaturase.…”