Influence of Cu doping in borosilicate bioactive glass and the properties of its derived scaffolds

Wang, Hui; Zhao, Shichang; Xiao, Wei; Xue, Jingzhe; Yan, Shen; Zhou, Jie; Huang, Wenhai; Rahaman, Mohamed N.; Zhang, Changqing; Wang, Deping

doi:10.1016/j.msec.2015.08.027

Cited by 53 publications

(29 citation statements)

References 46 publications

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“…The surface of GO contained a large number of functional groups, such as –COOH and –OH[ 57 - 59 ]. These functional groups could adsorb Ca ions in SBF, and Ca ions could continue to adsorb PO 4 ions to nucleate and grow, thereby forming a calcium-phosphorus layer[ 60 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation

Shuai

Yang

et al. 2020

IJB

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Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was introduced into the PLLA scaffold prepared by selective laser sintering to accelerate degradation. The reason was that GO with a large number of oxygen-containing functional groups attracted water molecules and transported them into scaffold through the interface microchannels formed between lamellar GO and PLLA matrix. More importantly, hydrogen bonding interaction between the functional groups of GO and the ester bonds of PLLA induced the ester bonds to deflect toward the interfaces, making water molecules attack the ester bonds and thereby breaking the molecular chain of PLLA to accelerate degradation. As a result, some micropores appeared on the surface of the PLLA scaffold, and mass loss was increased from 0.81% to 4.22% after immersing for 4 weeks when 0.9% GO was introduced. Besides, the tensile strength and compressive strength of the scaffolds increased by 24.3% and 137.4%, respectively, due to the reinforced effect of GO. In addition, the scaffold also demonstrated good bioactivity and cytocompatibility.

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Section: Resultsmentioning

confidence: 99%

Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation

Shuai

Yang

et al. 2020

IJB

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“…The US Food and Drug Administration (FDA) has approved borate‐based fibrous structures as wound dressing products (Mirragen™, ETS Wound Care LLS, USA) 4 . BGs offer also the possibility to be easily modified by introducing therapeutically active ions, for example, Ga, Ag, Zn, Cu, in order to improve their functionality and to extend their applications 33,52,60‐65 . For instance, copper has been considered as therapeutic ion since it is known to stimulate angiogenesis and to provide antibacterial effects.…”

Section: Introductionmentioning

confidence: 99%

“…In previous investigations, these effects were proven by testing Cu-doped borate BGs in in vitro and in vivo studies. 58,62,63 Therefore, in this work we combined MC and PCL to fabricate suitable fiber mats for wound healing applications and further improved their functionality by introducing MH and borate BG particles. It is hypothesized that the effects of MH and BG can be potentiated and therefore reduced amounts of these therapeutically agents can be used to achieve satisfactory outcomes.…”

mentioning

confidence: 99%

Production of a novel poly(ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey

et al. 2020

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Wound dressings produced by electrospinning exhibit a fibrous structure close to the one of the extracellular matrix of the skin. In this article, electrospinning was used to fabricate fiber mats based on the well-known biopolymers poly(ϵ-caprolactone) (PCL) and methylcellulose (MC) using benign solvents. The blend fiber mats were crosslinked using Manuka honey and additionally used as a biodegradable platform to deliver bioactive glass particles. It was hypothesized that a dual therapeutic effect can be achieved by combining Manuka honey and bioactive glass. Morphological and chemical examinations confirmed the successful production of submicrometric PCL-MC fiber mats containing Manuka honey and bioactive glass particles. The multifunctional fiber mats exhibited improved wettability and suitable mechanical properties (ultimate tensile strength of 3-5 MPa). By performing dissolution tests using simulated body fluid, the improved bioactivity of the fiber mats by the addition of bioactive glass was confirmed. Additionally, cell biology tests using human dermal fibroblasts and human keratinocytes-like HaCaT cells showed the potential of the fabricated composite fiber mats to be used as wound dressing, specially due to the ability to support wound closure influenced by the presence of bioactive glass. Moreover, based on the results of the antibacterial tests, it is apparent that an optimization of the electrospun fiber mats is required to develop suitable wound dressing for the treatment of infected wounds.

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“…Borosilicate-based BGs (BBGs) have been previously studied as biomaterials and have shown relevant capacity as osteointegrative antibacterial materials to be used in BTE [23,24]. BBGs have been also incorporated into scaffolds: Wang et al [25] successfully incorporated copper doped borosilicate glasses (BBGs-Cu) into a polymeric scaffold for tissue engineering purposes. They observed an improvement in the stability of the glass network and the BBGs-Cu promoted the angiogenesis in rat calvarial defects.…”

Section: Introductionmentioning

confidence: 99%

Reinforcement of poly-l-lactic acid electrospun membranes with strontium borosilicate bioactive glasses for bone tissue engineering

et al. 2016

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Herein, for the first time, we combined poly-L-lactic acid (PLLA) with a strontium borosilicate bioactive glass (BBG-Sr) using electrospinning to fabricate a composite bioactive PLLA membrane loaded with 10% (w/w) of BBG-Sr glass particles (PLLA-BBG-Sr). The composites were characterised by scanning electron microscopy (SEM) and microcomputer tomography (l-CT), and the results showed that we successfully fabricated smooth and uniform fibres (1-3 lm in width) with a homogeneous distribution of BBG-Sr microparticles (<45 lm). Degradation studies (in phosphate buffered saline) demonstrated that the incorporation of BBG-Sr glass particles into the PLLA membranes increased their degradability and water uptake with a continuous release of cations. The addition of BBG-Sr glass particles enhanced the membrane's mechanical properties (69% higher Young modulus and 36% higher tensile strength). Furthermore, cellular in vitro evaluation using bone marrow-derived mesenchymal stem cells (BM-MSCs) demonstrated that PLLA-BBG-Sr membranes promoted the osteogenic differentiation of the cells as demonstrated by increased alkaline phosphatase activity and up-regulated osteogenic gene expression (Alpl, Sp7 and Bglap) in relation to PLLA alone. These results strongly suggest that the composite PLLA membranes reinforced with the BBG-Sr glass particles have potential as an effective biomaterial capable of promoting bone regeneration. Statement of Significance PLLA membranes were reinforced with 10% (w/w) of strontium-bioactive borosilicate glass microparticles, and their capacity to induce the osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) was evaluated. These membranes presented an increased: degradability, water uptake, Young modulus and tensile strength. We also demonstrated that these membranes are non-cytotoxic and promote the attachment of BM-MSCs. The addition of the glass microparticles into the PLLA membranes promoted the increase of ALP activity (under osteogenic conditions), as well as the BM-MSCs osteogenic differentiation as shown by the upregulation of Alpl, Sp7 and Bglap gene expression. Overall, we demonstrated that the reinforcement of PLLA with glass microparticles results in a biomaterial with the appropriate properties for the regeneration of bone tissue.

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Influence of Cu doping in borosilicate bioactive glass and the properties of its derived scaffolds

Cited by 53 publications

References 46 publications

Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation

Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation

Production of a novel poly(ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey

Reinforcement of poly-l-lactic acid electrospun membranes with strontium borosilicate bioactive glasses for bone tissue engineering

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