Influence of Corynebacterium parvum-per on disease progression in the NZB/W model of systemic lupus erythematosus

Krause, G; Martin, Liam; Fritzler, Marvin J.; Hart, David A.

doi:10.1016/0192-0561(92)90102-q

Cited by 4 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In preclinical models, it is possible to induce autoimmunity in a susceptible host (usually mice and rats) which can then mimic aspects of the disease, but such studies may not be relevant to the initial disease process or even the exacerbations of tissue damage (discussed in more detail below). Even in “natural” forms of some conditions (e.g., the NZB/W model of SLE), one can protect target organ integrity without overtly blocking the autoantibody profile ([ 7 – 9 ]; reviewed in [ 10 ]) and, therefore, separate potential inflammatory stimuli (e.g., autoantibodies) from actual target tissue damage (e.g., the kidney). Therefore, inducing immune-specific autoimmunity may not accurately reflect the mechanisms of initial disease induction and its progression in models of chronic inflammatory diseases such as murine RA, MS, and other conditions.…”

Section: Introductionmentioning

confidence: 99%

Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?

Hart

2015

International Journal of Inflammation

Self Cite

View full text Add to dashboard Cite

Inflammatory diseases and conditions can arise due to responses to a variety of external and internal stimuli. They can occur acutely in response to some stimuli and then become chronic leading to tissue damage and loss of function. While a number of cell types can be involved, mast cells are often present and can be involved in the acute and chronic processes. Recent studies in porcine and rabbit models have supported the concept of a central role for mast cells in a “nerve-mast cell-myofibroblast axis” in some inflammatory processes leading to fibrogenic outcomes. The current review is focused on the potential of extending aspects of this paradigm into treatments for multiple sclerosis and endometriosis, diseases not usually thought of as having common features, but both are reported to have activation of mast cells involved in their respective disease processes. Based on the discussion, it is proposed that targeting mast cells in these diseases, particularly the early phases, may be a fruitful avenue to control the recurring inflammatory exacerbations of the conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?

Hart

2015

International Journal of Inflammation

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the pyridine extract residues of Corynebacterium parvum Type I can increase the titer of anti–single‐stranded DNA in the NZB/W lupus mouse model. 42 The gut enrichment of Streptococcus was positively correlated with lupus nephritis and lupus activity. 43 , 44 Fusobacterium was significantly increased in patients with active SLE, 35 and we found a negative association with SLEDAI in Black patients in the current study.…”

Section: Discussionmentioning

confidence: 98%

“…For example, Corynebacterium and Streptococcus were decreased in Black participants versus White participants in both controls and patients in our report. However, the pyridine extract residues of Corynebacterium parvum Type I can increase the titer of anti–single‐stranded DNA in the NZB/W lupus mouse model 42 . The gut enrichment of Streptococcus was positively correlated with lupus nephritis and lupus activity 43,44 .…”

Section: Discussionmentioning

confidence: 99%

Racial Differences in Plasma Microbial Translocation and Plasma Microbiome, Implications in Systemic Lupus Erythematosus Disease Pathogenesis

Wen,

Ogunrinde,

Wan

et al. 2024

ACR Open Rheumatology

View full text Add to dashboard Cite

ObjectiveBlack groups have increased prevalence and accelerated pathogenicity of systemic lupus erythematosus (SLE) compared to other ethnic/racial groups. The microbiome and systemic microbial translocation are considered contributing factors to SLE disease pathogenesis. However, racial differences in the plasma microbiome and microbial translocation in lupus remain unknown.MethodsIn the current study, we investigated plasma levels of microbial translocation (lipopolysaccharide [LPS] and zonulin) and the plasma microbiome using microbial 16S RNA sequencing of Black and White patients with SLE and Black and White healthy controls.ResultsPlasma microbial translocation was increased in Black patients versus in White patients and in patients with SLE versus healthy controls regardless of race. Compared to sex, age, and disease status, race had the strongest association with plasma microbiome differences. Black groups (Black controls and Black patients) had lower α‐diversity than White groups (White controls and White patients) and more distinct β‐diversity. Black and White patients demonstrated differences in plasma bacterial presence, including Staphylococcus and Burkholderia. Compared to White patients, Black patients had higher SLE Disease Activity Index (SLEDAI) scores and urinary protein levels as well as a trend for increased anti–double‐stranded DNA (dsDNA) antibody levels consistent with the known increased severity of lupus in Black patients overall. Certain plasma bacteria at the genus level were identified that were associated with the SLEDAI score, urinary protein, and anti‐dsDNA antibody levels.ConclusionThis study reveals racial differences in both quality and quantity of plasma microbial translocation and identified specific plasma microbiome differences associated with SLE disease pathogenesis. Thus, this study may provide new insights into future potential microbiome therapies on SLE pathogenesis.

show abstract

Partial characterization of the enhanced survival of female NZB/W mice treated with lithium chloride

Hart¹,

Done²,

Benediktsson³

et al. 1994

International Journal of Immunopharmacology

View full text Add to dashboard Cite

Influence of Corynebacterium parvum-per on disease progression in the NZB/W model of systemic lupus erythematosus

Cited by 4 publications

References 13 publications

Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?

Curbing Inflammation in Multiple Sclerosis and Endometriosis: Should Mast Cells Be Targeted?

Racial Differences in Plasma Microbial Translocation and Plasma Microbiome, Implications in Systemic Lupus Erythematosus Disease Pathogenesis

Partial characterization of the enhanced survival of female NZB/W mice treated with lithium chloride

Contact Info

Product

Resources

About