Influence of Corona Plasma Treatment on Polypropylene and Polyamide 6.6 on the Release of a Model Drug

Abstract

Low-temperature plasma has been studied for the textile industry as an environmentally friendly alternative to conventional finishing treatments but its biomedical applications are limited. The present work is devoted to analyze how plasma treatment modifies the wetting properties of polypropylene and polyamide 6.6 fabrics and its influence on the drug release from these textile materials. Drug release studies from textiles pretreated by plasma are unexplored and constitute an innovative research that could provide a new way to develop controlled drug delivery systems. Methods of surface analysis for polypropylene and polyamide 6.6, including contact angle measurements, drop test, SEM, as well as drug release studies, using ketoprofen as a model drug, are considered in this research. Results obtained have shown that the increase of the hydrophilic properties of polypropylene and polyamide fabrics with plasma treatment reverts in a higher release of the model drug studied from plasma-treated fabrics.

Numerical Simulation of the Characteristics of Electrons in Bar-plate DC Negative Corona Discharge Based on a Plasma Chemical Model

“…In order to maintain the balance field by requiring fewer electrons into the anode surface, so from t 4 -t 6 , only a small DC current (I =1mA) will remain in the circuit.…”

“…The higher the voltage grade, the more energy loss [3,4]. In the meantime, corona discharge has been employed as an effective tool in many industrial applications such as electrostatic precipitators, disinfection, ozone generators, surface treatment, ignition, electrostatic painting, and so on [5][6][7]. In recent year, the application of corona discharge has been expanded broadly.…”

Corona plasma modification of polyamide 66 for the design of textile delivery systems for cosmetic therapy

“…In the quest for a simpler approach, in previous works we investigated the possibility of modifying the surface chemistry on the first nanometers of the fiber by low temperature plasma as a means of generating new surface moieties capable of interacting with the drug and thus achieving a controlled release. Corona plasma treatment of PA66 fibers which were then loaded with ketoprofen increased the drug percentage released [16].…”

Space and Time Domain Finite Volume Method for Numerical Simulation of Negative Corona Discharge in Air

“…[2,3]. In the meantime, corona discharge has been employed as an effective tool in many industrial applications such as electrostatic precipitators, disinfection, ozone generators, surface treatment, ignition, and electrostatic painting [4][5][6]. The features of a corona discharge vary considerably among different gases.…”