Crop residue harvest occurs on about 40% of Nebraska's 3,700,000 ha of corn (Zea mays L.) land, primarily for feeding of beef cattle. Immobilization of applied N is expected to be less with residue harvest due to reduced microbial activity for digestion of high C/N ratio organic material. Residue reduction may aff ect subsequent crop yield and response to applied N. Field research was conducted at three locations over 2 yr in eastern Nebraska for irrigated, no-till corn following corn to determine residue harvest eff ects on yield and the economically optimal nitrogen rate (EONR). Study sites had deep silt loam or silty clay loam soil with good water infi ltration and plantavailable water holding capacity. Mean aboveground biomass N content, applied N recovery effi ciency, and grain yield were 22, 43, and 20% higher with >75% residue removal compared with no residue removal. Agronomic effi ciency of applied N use was not consistently aff ected. Th e residue removal eff ects were oft en greater in the third compared with second year of continuous corn. Th e residue removal eff ect on EONR was not consistent over site-years, and the mean reduction in EONR with residue removal was between 10 and 20 kg ha -1 .While removal of some corn residue is expected to result in higher yield of the following corn crop, reduction in applied N need cannot be well predicted before planting.