Influence of core body temperature on Tryptophan metabolism, kynurenines, and estimated IDO activity in critically ill patients receiving target temperature management following cardiac arrest

Schefold, Joerg C.; Fritschi, Nora; Fusch, Gerhard; Bahonjic, Aldin; Doehner, Wolfram; Haehling, Stephan von; Pschowski, René; Storm, Christian; Schröeder, Tim

doi:10.1016/j.resuscitation.2016.07.239

Cited by 10 publications

(7 citation statements)

References 35 publications

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“…A possible explanation for this pronounced difference is suggested to be hypothermia-induced tryptophan catabolism and lymphocytopenia, leading to immune paresis. 19,46 Since we wanted to explore the effect of induced hypothermia, not fever control, we decided not to restrict the inclusion to febrile patients. However, we are aware that febrile patients may be different in many ways, compared to normothermic and spontaneously hypothermic patients.…”

Section: Resultsmentioning

confidence: 99%

Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Wesche

Jensen

Itenov

et al. 2018

The Lancet Respiratory Medicine

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Section: Resultsmentioning

confidence: 99%

Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Wesche

Jensen

Itenov

et al. 2018

The Lancet Respiratory Medicine

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“…The latter relates to the observation of adverse consequences of reperfusing organs that were exposed to acute ischemia, either as a pathologic event such as acute myocardial infarction or as a therapeutic strategy such as producing hypothermia to protect brain tissue following unconscious cardiac arrest. Induced hypothermia raised the chance of developing a serious infection/sepsis ( Schefold et al, 2016 ). This was directly related to IDO overexpression and Trp suppression caused by low body temperature.…”

Section: Indoleamine-23-dioxygenase As a Target In Anoxic States Related To Oxidative Stressmentioning

confidence: 99%

Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System

et al. 2021

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Indoleamine-2,3-dioxygenase (IDO) is the “rate-limiting” enzyme in the kynurenine (Kyn) pathway of the tryptophan (Trp) catabolism. By its immune-modulatory effect, IDO initiates changes to the physiologically balanced immune state and plays a key role in the pathogenesis of various diseases, as well as in the perioperative setting during surgery. In autoimmune processes, highly malignant cancers such as glioblastoma or organ transplantation, IDO’s involvement has been studied extensively. However, in severe systemic infections, as present in sepsis, it is not yet completely understood. Hereafter, in this narrative review, we present the current knowledge of IDO’s implication on such complex immune-related processes. Moreover, we address the role of IDO as a predictive biomarker as well as a therapeutic target for immune-mediated diseases. Finally, we discuss IDO in the setting of surgical trauma-induced stress and highlight its promising use as a biomarker in the pre-operative setting for all disciplines involved in the decision-making process and treatment of patients undergoing surgery.

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“…Известно, что управляемая гипотермия у таких пациентов значимо улучшает неврологический прогноз, однако повышает риск возникновения инфекционных осложнений. Отмечено, что снижение сывороточных уровней триптофана и повышение активности индоламин-2,3-диоксигеназы при гипотермии связано с неблагоприятным исходом, вероятно, по причине увеличения чувствительности к инфекционным осложнениям и сепсису под воздействием низких температур, в то время как у пациентов с благоприятным исходом сохранялась тенденция к более высоким значениям триптофана и низкой активности индоламин-2,3-диоксигеназы [25].…”

Section: сердечно-сосудистые заболеванияunclassified

The role of human and microbial metabolites of triptophane in severe diseases and critical ill (review)

Getsina

Львовна²,

Chernevskaya

et al. 2020

Journal of Clinical Practice

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The growing interest in metabolite circulating in the blood is associated with the accumulation of factual material on the involvement of low-molecular compounds in the development of a number of serious diseases. This review reveals the effect of a whole class of chemical compounds― tryptophan metabolites― on various pathological processes. The following keywords were used to find papers published in the PubMed database for the last 10 years: names of natural indole compounds, methods for their detection, nosology of diseases and critical ill patients. The data is presented in sections, which provide data on the study of tryptophan metabolites in a variety of groups of diseases, such as cancer, cardiovascular disease, kidney disease, bowel, mental disorders, atherosclerosis, etc. Particular attention is paid to the role of indole compounds that enter the systemic circulation as a result of microbial biotransformation of tryptophan, serotonin and other indole metabolites, which can be attributed to the "common metabolites" of humans and microbiota. The most interesting clinical studies are summarized in summary tables and figures. A number of indole metabolites are considered as potential biomarkers. The authors of the review substantiate the metabolomic approach to the study of a number of oncological, septic, mental and other intractable diseases, which opens up new possibilities of influence on the pathological process by targeted regulation in the metabolome/microbiome system.

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Influence of core body temperature on Tryptophan metabolism, kynurenines, and estimated IDO activity in critically ill patients receiving target temperature management following cardiac arrest

Cited by 10 publications

References 35 publications

Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System

The role of human and microbial metabolites of triptophane in severe diseases and critical ill (review)

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