Influence of copper (II) ions and its derivatives on radiosensitivity of Escherichia coli

Toxicity of free and various aminocarboxylic ligands sequestered copper(II) ions to Escherichia coli

“…However, the genotoxic effects of complexes depend on the characteristics of the sequestering ligands. This particular aspect should be taken into consideration, in case of Cu-NTA for its possible implications in apoptosis of human leukemia HL-60 cells [51,52] and also in radiosensitizing behaviour [19]. As synthetic chelating ligands are released into the ecosystem due to wide range of industrial applications, metals ions in environmental samples may be present mostly in complexed state [32].…”

“…Our earlier in vitro studies showed that Cu-complexes in question retain the radiosensitizing property of Cu 2+ ions [16][17][18] radiosensitise Escherichia coli cells like Cu 2+ ions [19]. These results spurred our interest for a more detailed study on toxic effects of these additives in E. coli.…”