Influence of continuous haemofiltration-related hypothermia on haemodynamic variables and gas exchange in septic patients

Matamis, Dimitrios; Tsagourias, Matthew; Koletsos, K.; Riggos, D; Mavromatidis, K.; Sombolos, Kostas; Bursztein, S

doi:10.1007/bf01710654

Cited by 67 publications

(44 citation statements)

References 18 publications

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“…removal of humoral factors mediating the hyperdynamic response. Furthermore, if a decrease in BT would be the main factor attenuating the hyperdynamic response to trauma, a decrease in VO 2 in patients subjected to CVVH would be expected [27], but this was not the case.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms contributing to the attenuation of the hyperdynamic state remain speculative and may involve simple cooling effects ( [26,27], as observed in the early course of CVVH, i.e. on days 1 and 2 of the present study) or removal of filterable cardiodepressant mediators or factors involved in impaired microcirculation or cellular oxygen utilization [13,14,15].…”

Section: Discussionmentioning

confidence: 99%

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Prophylactic hemofiltration in severely traumatized patients: effects on post-traumatic organ dysfunction syndrome

et al. 2001

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prophylactic hemofiltration in severely traumatized patients: effects on post-traumatic organ dysfunction syndrome

et al. 2001

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“…Unfortunately, this is a nonspecific technique in which potentially beneficial molecules ma also be removed, ultimately leading to a less effective host response to infection. A recent trial by Matamis et al [20] failed to demonstrate any beneficial hemodynamic effects from this procedure. However, hemofiltration may play a role in those patients who have baseline high concentrations of circulating pro-inflammatory mediators [21].…”

Section: Hemofiltration Of Circulating Cytokinesmentioning

confidence: 96%

Adjunctive therapies for sepsis and septic shock

Breen

Tunkel

1999

Curr Infect Dis Rep

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The inflammatory cascade that ensues after an infectious insult is protean in its manifestations, resulting in mild self-limited illness in some patients, while progressing to fulminant sepsis and multisystem organ failure in others. Research into the pathophysiology of this cascade has been intense, but advances in the treatment of sepsis have been few and far between. Although mortality rates have been impacted slightly in patients with sepsis--with improved survival in certain patient subgroups--overall survival still reaches only 55% to 60%. In this paper we will review some of the most recent advances in the therapy of the sepsis syndrome, specifically the roles of cytokine modifiers, supranormal delivery of oxygen, granulocyte colony-stimulating factor administration in leukopenic patients, and parenteral nutrition. Hopefully, these modalities represent additional steps in the path towards a meaningful improvement in survival from this catastrophic condition.

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“…during continuous renal replacement therapy (CRRT) [22,23,32] -Guidance of thermal management during therapeutic hypothermia or targeted normothermia after cardiac arrest [27] -As part of a diagnostic algorithm, e.g. SIRS (systemic inflammatory response syndrome) or sepsis -As part of an ICU scoring system, e.g.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a novel noninvasive continuous core temperature measurement system with a zero heat flux sensor using a manikin of the human body

Brandes

Perl

Bauer

et al. 2015

Biomedical Engineering / Biomedizinische Technik

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Reliable continuous perioperative core temperature measurement is of major importance. The pulmonary artery catheter is currently the gold standard for measuring core temperature but is invasive and expensive. Using a manikin, we evaluated the new, noninvasive SpotOn™ temperature monitoring system (SOT). With a sensor placed on the lateral forehead, SOT uses zero heat flux technology to noninvasively measure core temperature; and because the forehead is devoid of thermoregulatory arteriovenous shunts, a piece of bone cement served as a model of the frontal bone in this study. Bias, limits of agreements, long-term measurement stability, and the lowest measurable temperature of the device were investigated. Bias and limits of agreement of the temperature data of two SOTs and of the thermistor placed on the manikin's surface were calculated. Measurements obtained from SOTs were similar to thermistor values. The bias and limits of agreement lay within a predefined clinically acceptable range. Repeat measurements differed only slightly, and stayed stable for hours. Because of its temperature range, the SOT cannot be used to monitor temperatures below 28°C. In conclusion, the new SOT could provide a reliable, less invasive and cheaper alternative for measuring perioperative core temperature in routine clinical practice. Further clinical trials are needed to evaluate these results.

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Influence of continuous haemofiltration-related hypothermia on haemodynamic variables and gas exchange in septic patients

Cited by 67 publications

References 18 publications

Prophylactic hemofiltration in severely traumatized patients: effects on post-traumatic organ dysfunction syndrome

Prophylactic hemofiltration in severely traumatized patients: effects on post-traumatic organ dysfunction syndrome

Adjunctive therapies for sepsis and septic shock

Evaluation of a novel noninvasive continuous core temperature measurement system with a zero heat flux sensor using a manikin of the human body

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