2021
DOI: 10.1124/jpet.121.000655
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Influence of Contingent and Noncontingent Drug Histories on the Development of High Levels of MDPV Self-Administration

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Cited by 3 publications
(4 citation statements)
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“…When allowed to self-administer the stimulant drug MDPV, a subset rats rapidly develop patterns of responding that result in significantly greater levels of drug-intake (high-responders) than low-responder rats self-administering MDPV, or rats that self-administer cocaine. These high-responder rats exhibit behaviors thought to be consistent with stimulant use disorder in humans, including high levels of drug-taking and -seeking, and reach higher final ratios under progressive ratio schedules of reinforcement (Gannon et al, 2017;Doyle et al, 2021a;Abbott et al, 2022). The primary goal of this study was to evaluate the effects of several drugs that interact with receptors that have been targeted for the development of medications for stimulant use disorder to determine if their potency and effectiveness to reduce drug-taking differed as a function of: (1) the self-administered drug (MDPV versus cocaine), ( 2) the behavioral phenotype (high-responder versus low-responder), or (3) sex (male versus female).…”
Section: Discussionmentioning
confidence: 99%
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“…When allowed to self-administer the stimulant drug MDPV, a subset rats rapidly develop patterns of responding that result in significantly greater levels of drug-intake (high-responders) than low-responder rats self-administering MDPV, or rats that self-administer cocaine. These high-responder rats exhibit behaviors thought to be consistent with stimulant use disorder in humans, including high levels of drug-taking and -seeking, and reach higher final ratios under progressive ratio schedules of reinforcement (Gannon et al, 2017;Doyle et al, 2021a;Abbott et al, 2022). The primary goal of this study was to evaluate the effects of several drugs that interact with receptors that have been targeted for the development of medications for stimulant use disorder to determine if their potency and effectiveness to reduce drug-taking differed as a function of: (1) the self-administered drug (MDPV versus cocaine), ( 2) the behavioral phenotype (high-responder versus low-responder), or (3) sex (male versus female).…”
Section: Discussionmentioning
confidence: 99%
“…The temperature-and humidity-controlled vivarium operated on a 14/10 hour light cycle (lights on at 6am) and experiments were conducted while lights were on. A subset of male rats (n=9) also participated in another self-administration experiment before beginning this study, where they self-administered MDPV and either cocaine, ketamine, nicotine, or fentanyl for ~6 weeks (Doyle et al, 2021a). The self-administration behavior of these rats did not differ from the rats with no prior experimental history.…”
Section: Subjectsmentioning
confidence: 99%
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