Influence of Contact Lens Material Surface Characteristics and Replacement Frequency on Protein and Lipid Deposition

Hart, Dean E.

doi:10.1097/00006324-199909000-00016

Cited by 8 publications

(5 citation statements)

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“…There are very few studies that simultaneously assessed both dehydration and deposition characteristics of hydrogel materials (Jones et al. , 1997, 2000; Hart, 1999). Morgan and Efron (2003) reported greater deposition on etafilcon A compared to balafilcon A lenses in an in vivo study.…”

Section: Discussionmentioning

confidence: 99%

Contact lens material characteristics associated with hydrogel lens dehydration

Ramamoorthy

Sinnott

Nichols

2010

Ophthalmic and Physiological Optics

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Section: Discussionmentioning

confidence: 99%

Contact lens material characteristics associated with hydrogel lens dehydration

Ramamoorthy

Sinnott

Nichols

2010

Ophthalmic and Physiological Optics

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“…[7][8][9][10] After deposition, the conformation of proteins may change from a native state to a non-native or denatured state. [11][12][13][14][15] For the particular case of contact lenses, it has been well established that tear film proteins rapidly deposit onto contact lenses 14,[16][17][18][19][20][21][22][23][24][25] and that protein deposited on siloxanebased materials tends to be relatively low in quantity, but a higher percentage of the deposited protein is denatured. [13][14][15][16] Denatured protein on any biomaterial poses a risk for end users, because it has been implicated as a cause of various inflammatory reactions.…”

Section: Introductionmentioning

confidence: 99%

Measuring the kinetics and activity of adsorbed proteins: In vitro lysozyme deposited onto hydrogel contact lenses over short time periods

Hall

Jones

Forrest

2012

J Biomedical Materials Res

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A new process has been developed to determine the biological activity of an intact layer of lysozyme deposited onto a biomaterial surface. This process is applied to a number of common hydrogel contact lenses. The activity of the surface-adsorbed protein is measured using a standard micrococcal activity assay, with extra steps to distinguish between protein on the surface and protein in solution. This is in contrast to protein extraction work in which the activity of all adsorbed protein is measured. For ionic materials, which are known to deposit large amounts of protein, particularly positively charged proteins such as lysozyme, there is evidence for loosely bound protein re-entering the solution, thus making it impossible to truly separate out the surface-adsorbed protein. This optimized process provides the first quantification of the biological activity of an intact layer of surface-adsorbed protein at a hydrogel interface.

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“…The hydrophobic portion of the lipids was attached to the underlying contact lens material. The earliest observations of the interaction of lipids and hydrogel contact with their lenses were made by Hart et al , Various microscopic and histochemical staining analyses revealed that lipids were present and a major component of all deposits, with cholesteryl ester as the predominant lipid. − As shown in Figure , the adsorption and absorption of lipids by the various silicone hydrogel contact lenses were determined by visualization with fluorescence staining. These silicone hydrogel contact lenses are immersed in an artificial tear lipid solution and then washed by a conventional procedure.…”

Section: Antifouling Properties On Biomimetic Silicone Hydrogel Conta...mentioning

confidence: 99%

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Ishihara,

Shi,

Fukazawa

et al. 2023

ACS Appl. Bio Mater.

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Contact lenses are one of the most successful applications of biomaterials. The chemical structure of the polymers used in contact lenses plays an important role in determining the function of contact lenses. Different types of contact lenses have been developed based on the chemical structure of polymers. When designing contact lenses, materials scientists consider factors such as mechanical properties, processing properties, optical properties, histocompatibility, and antifouling properties, to ensure long-term wear with minimal discomfort. Advances in contact lens materials have addressed traditional issues such as oxygen permeability and biocompatibility, improving overall comfort, and duration of use. For example, silicone hydrogel contact lenses with high oxygen permeability were developed to extend the duration of use. In addition, controlling the surface properties of contact lenses in direct contact with the cornea tissue through surface polymer modification mimics the surface morphology of corneal tissue while maintaining the essential properties of the contact lens, a significant improvement for long-term use and reuse of contact lenses. This review presents the material science elements required for advanced contact lenses of the future and summarizes the chemical methods for achieving these goals.

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Influence of Contact Lens Material Surface Characteristics and Replacement Frequency on Protein and Lipid Deposition

Cited by 8 publications

References 0 publications

Contact lens material characteristics associated with hydrogel lens dehydration

Contact lens material characteristics associated with hydrogel lens dehydration

Measuring the kinetics and activity of adsorbed proteins: In vitro lysozyme deposited onto hydrogel contact lenses over short time periods

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

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