Influence of Concomitant Arterial Hypertension on Activity of Inflammatory Process in Patients With Community-Acquired Pneumonia

Abstract

The aim of the work was to determine the diagnostic value of the markers of surfactant protein D (SP-D) and C-reactive protein (C-RP) in patients with community-acquired pneumonia (CAP) with concomitant arterial hypertension (AH) and its effects on the activity of the inflammatory process. The study included 79 people. Among them, 63 patients with CAP and 16 healthy individuals who were a control group. Depending on the presence of hypertension, the patients were divided into two groups. The first group included 26 patients with CAP with AH, the second – 37 patients with CAP without AH. All patients were given general-clinical methods of examination, radiography of the chest organs in two projections. Plasma levels of SP-D and C-RP were determined. Reliable connection (p<0.05) was determined between the presence of AH and the probability of occurrence of CAP (OR - odds ratio 2.27 [95 % CI 1.05–4.94]). The level of SP-D and C-RP in patients with AH on the first day was significantly higher than in healthy subjects (p<0.05). In patients in the first group, SP-D levels were significantly higher (p<0.05) for the first, third and ninth day relative to the second group. The existence of a direct tie of average strength between the presence of AH and SP-D (R=0.41, p<0.05) has been determined. The presence of a direct correlation link of mean strength (R=0.38; p<0.05) between the AH and the level of C-RP indicates that arterial hypertension in patients with CAP increases the activity of the systemic inflammatory response.

The Opportunity of Surfactant Protein D as a Potential Biomarker for Detecting Acute Lung Injury

“…If AT2 cells are damaged (e.g., as a result of the SARS COV-2 virus), an increase in circulating SP-D levels cannot be used as a marker for tissue damage. A decrease in circulating SP-D levels is most likely a sign of lung organ injury (Shtepa 2018).…”