“…Although computational studies have shown great potential in clinical decision-making 11,12,17,18,21,38,45,48,53,54 , they are associated with uncertainties regarding the prediction of realistic contact conditions. On the other hand, experimental studies 16,24,26,34,36,55 lack the consideration of the complex soft tissue structures acting at the lower extremity. Moreover, human cadaver specimens do not allow reproducible and comparable evaluations of different parameters due to the limited acquisition of samples and their decay.…”