Influence of combined aerobic and resistance training on metabolic control, cardiovascular fitness and quality of life in adolescents with type 1 diabetes: a randomized controlled trial

D’hooge, Roseline; Hellinckx, Tinneke; Laethem, Christophe Van; Stegen, Sanne; Schepper, Jean De; Aken, Sara Van; Dewolf, Daniel; Calders, Patrick

doi:10.1177/0269215510386254

Cited by 97 publications

(128 citation statements)

References 25 publications

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“…In addition, the results of the present study showed a slight increase in HDL concentration after endurance (9.52%) and sprint (16.66%) exercise trainings. These slight increases may be attributable to changes of lipoprotein lipase (28) and cholesteryl ester transfer protein activity following exercise training (29). Besides, the findings are consistent with other studies (5,30), which showed a positive and significant correlation between PON1 activity and serum HDL levels.…”

Section: Discussionsupporting

confidence: 91%

The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

et al. 2017

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Background: Paraoxonase-1 (PON1) is an anti-atherosclerotic enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein (LDL) against oxidation. There are contradictory studies about the effects of exercise training on PON1 activity. Objectives: The purpose of the present study was to elucidate the effects of sprint and endurance exercise training on serum PON1 activity and lipid profile in rats. Methods: Twenty-four Albino Wistar rats were divided to sedentary control (SC), endurance training (ET), and sprint training (ST) groups. The animals were subjected to endurance (at a speed of 27 m/minute) and sprint (at a speed of 40 to 54 m/minute) training on a treadmill for 6 weeks, 6 days per week. Using commercial kits, PON1 activity and lipid profile levels were measured by spectrophotometry and enzymatic methods, respectively. The data were analyzed by one-way analysis of variance followed by Tukey's post-hoc test at P < 0.05 level. Results: Both ET and ST regimens increased PON1 activity in the serum, and the alteration was greater following ST than ET (F1, 23 = 17.87, P = 0.001). In contrast, neither ST nor ET changed significantly the serum levels of triglyceride (F1, 23 = 0.288, P = 0.753), total cholesterol (F1, 23 = 0.385, P = 0.685), LDL (F1, 23 = 1.07, P = 0.361), and HDL (F1, 23 = 1.36, P = 0.277). In addition, serum PON1 activity was positively correlated with serum HDL levels in rats (R = 0.44, P = 0.032). Conclusions: Despite the lack of change in serum lipid profile, sprint training can lead to greater protection against lipid peroxidation than endurance training through increases in serum PON1 activity.

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Section: Discussionsupporting

confidence: 91%

The Effect of Exercise Training Type on Paraoxonase-1 and Lipid Profile in Rats

et al. 2017

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“…16,17 However, only 4 studies have studied the impact of both aerobic and anaerobic training in the same patients with T1D. [18][19][20][21] Reports from these studies to date have not provided estimates of rate of change in plasma or interstitial fluid glucose in the same individual with aerobic and resistance activity under otherwise comparable dietary and insulin managements conditions.…”

Section: Impact Of Aerobic Versus Anaerobic Exercise On Plasma Glucosmentioning

confidence: 99%

Physical Activity Capture Technology With Potential for Incorporation Into Closed-Loop Control for Type 1 Diabetes

Dadlani

Levine

McCrady-Spitzer

et al. 2015

J Diabetes Sci Technol

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Type 1 diabetes (T1D) is characterized by complete or near complete absence of endogenous insulin secretion resulting in the need to deliver exogenous insulin in an individualized, precise manner.1 Current clinically approved technologies to replace insulin result in unacceptable risk for hypoglycemia, hyperglycemia, and glycemic variability (GV).2 Changes in plasma glucose concentration are more pronounced in T1D, occur rapidly and are related to food intake, physical activity and imprecise insulin delivery. The maturation of technologies such as continuous glucose monitoring (CGM), continuous subcutaneous insulin infusion (CSII) or insulin pump, rapid acting insulin analogs and closed-loop control (CLC) algorithms that deliver insulin based on CGM data processing has resulted in CLC therapy becoming an area of active research with rapid therapeutic translation to clinical practice. 4 Current CLC studies show significant improvement in hypoglycemia and a bigger burden of hyperglycemia relative to time spent in hypoglycemic range. 4,5 Occurrence of hyper and hypoglycemia with current CLC, the burden associated with current CLC and limitations of eligible populations to use current technologies indicate the need for further innovation. Important variables in this context with potentially significant effect sizes are physical activity and meals. Significant efforts have been made to model the aforementioned parameters and understand their effect on glucose-insulin dynamics by incorporating/adapting them into CLC simulators. 6,7 Even though the day to day effect of physical activity on glucose status poses major challenges for T1D, limited research in this area has been conducted. 8 Since obesity and type 2 diabetes mellitus (T2D), 2 major disorders of whole body energy balance, continue to rise worldwide, most research to-date regarding physical activity capture device use has been pursued in these 2 disorders.9,10 T2D is characterized by hyperglycemia for a significant proportion of the day with the majority of such subjects having limited hypoglycemia AbstractPhysical activity is an important determinant of glucose variability in type 1 diabetes (T1D). It has been incorporated as a nonglucose input into closed-loop control (CLC) protocols for T1D during the last 4 years mainly by 3 research groups in single center based controlled clinical trials involving a maximum of 18 subjects in any 1 study. Although physical activity data capture may have clinical benefit in patients with T1D by impacting cardiovascular fitness and optimal body weight achievement and maintenance, limited number of such studies have been conducted to date. Clinical trial registries provide information about a single small sample size 2 center prospective study incorporating physical activity data input to modulate closed-loop control in T1D that are seeking to build on prior studies. We expect an increase in such studies especially since the NIH has expanded support of this type of research with additional grants starting in the second hal...

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“…Other studies revealed similar significant results [4][5][6]9,19,20] which showed that improvement was associated with the frequency of physical activity [4,20]. Slight decrease in HbA1c was observed with combination of aerobic and muscle strength exercise training program [10,14] and was better with competitive sport [21].…”

Section: Discussionmentioning

confidence: 63%

“…Many studies of type 1 diabetes children or adolescent have demonstrated that exercise have a beneficial effect in type 1 diabetes. It lowers blood pressure [4], improves lipid profile [5,6], endurance capacity [7], body composition of fat to muscle mass ratio [8][9][10][11], physical fitness [7], insulin sensitivity [12], bone mineral density [11], vascular function [7], antioxidant capacity [13] and overall quality of the life [10,14].…”

Section: Introductionmentioning

confidence: 99%