Influence of coexisting disease on survival on renal-replacement therapy

Comorbidities and survival of patients with type 1 diabetes on renal replacement therapy

“…Several studies have, however, shown that comorbidities increase mortality among RRT patients [12][13][14], and a large European study reported that coronary artery disease, peripheral vascular disease and cerebrovascular disease all increase the risk of death by approximately 40% [9]. To our knowledge, only two small studies have estimated the effect of comorbidities on mortality in patients with diabetes on RRT, and no study has focused solely on patients with type 1 diabetes.…”

A validated age and comorbidity prognostic index for survival in dialysis patients

“…Both peripheral vascular disease and chronic obstructive pulmonary disease also showed a negative impact on survival. Vascular peripheral disease obtains a higher risk in our index than in others [8,10,13] by looking at our current practice, we noticed that when vascular disease turns into several clinical complications, it has a negative impact on our patients' survival. Moreover, our index points out the high mortality of patients with previous neoplasm, but only in those cases with less than 5 years' evolution since diagnosis.…”

“…Atrial fibrillation, not often included in most used comorbid indexes [8,10,13,14] is a relevant condition that increases mortality risk in both cohorts. Both peripheral vascular disease and chronic obstructive pulmonary disease also showed a negative impact on survival.…”

“…Our validation cohort was comprised of incident patients from the same center in which our original study was performed and who began dialysis in the 5-year period following the completion of the first study. Therefore, the current study provides an external validation in a temporal sense, but it could be considered an intermediate [19], between internal and external validation, because the individuals were collected from the same centre. This is notable, especially from a statistical perspective, but it is not as relevant from a clinical point of view.…”

Epidemiology of end-stage renal disease

“…Comorbidity, especially cardiovascular, is common in patients starting RRT and is a major factor influencing survival. Comorbidity scores have been developed to take this into account 39,40 .…”