Influence of clomiphene citrate on induced ovarian hyperstimulation and subsequent fertility in Damascus goats

Rateb, Sherif A.; El-Hamid, Ibrahim Samir Abd; Khalifa, Marwa A.; Ibrahim, Nermin H.; Younis, F.; El-Rayes, M.

doi:10.1016/j.smallrumres.2019.04.005

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…These data are in agreement with those reported by Abd El-Hamid et al ( 2015) where serum GLC concentration decreased at days 10 and 20 of induction of ovulation period in dromedary she-camels during breeding season. The same results were reported in several species, in goats, plasma GLC level decreased during ovarian dynamics and estrus activities (Rateb et al 2019). This reduction in plasma GLC with ovarian activities and increased of E2 hormone, due to uptake GLC by ovarian tissues to accommodate ovarian activities (Rabiee and Lean 2000).…”

Section: Changes In Blood Biochemical Constituents and Hormonal Profiles During Cycle Statussupporting

confidence: 84%

Blood Constituents, Antioxidant Activities and Hormonal Profile in She-camels (Camelus dormedarius) during different Physiological Statuses in the North Western Coast of Egypt

2021

Int J Vet Sci

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To monitor blood constituents and hormonal profiles in dromedary she-camels at different physiological statuses in the Northwestern Coast of Egypt, twenty-four she-camels, aged 7-10 years were used from December 2016 to March 2019. Animals were divided according estrous behavior and ultrasound scans of ovarian structures into estrus and non-estrus groups before natural mating. Pregnancy was diagnosed 30 days after mating by ultrasonography. Blood samples were collected from all animals during estrus and non-estrus and monthly during gestation and lactation periods. During the follicular phase GLC and P4 levels decreased (P<0.05). Levels of E2 and PRL increased (P<0.05). Follicles number and diameter in both ovaries increased (P<0.05) in estrus group. Cyclic status correlated negatively with GLC, P4, total number follicles of left ovary (TLO) and diameter follicles of left ovary (DLO) and positively with AST, E2 and DLO. In 1st trimester of pregnancy, GLC levels decreased. Higher (P<0.05) activity of ALT (2nd and 3rd trimesters) and ALP (1st and 2nd trimesters) were recorded. SOD and HP changed (P<0.05). Pregnancy status correlated negatively with GLC, ALP, HP and SOD and positively with TG and ALT. During lactation, ALB, CHOL, TG, ALT, ALP, P4 and PRL were affected (P<0.05). SOD and HP were higher (P<0.05) in 2nd and 1st trimester, respectively. Lactation status correlated negatively with P4 and PRL and positively with CHOL, ALB, ALP, ALT and TAC. In conclusion, the knowledge the values of hormonal, blood biochemical, antioxidant activities are necessary for diagnostic interpretation of pathological and adjusting the different functions throughout different physiological statuses under arid conditions.

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Section: Changes In Blood Biochemical Constituents and Hormonal Profiles During Cycle Statussupporting

confidence: 84%

Blood Constituents, Antioxidant Activities and Hormonal Profile in She-camels (Camelus dormedarius) during different Physiological Statuses in the North Western Coast of Egypt

2021

Int J Vet Sci

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Associations among the largest follicle, preovulatory estradiol concentrations, and predominant vaginal epithelial cells at the completion of hormonal ovarian stimulation for fixed‐time artificial insemination in goats

Promsao,

Yama,

Suriard

et al. 2024

Reprod Domestic Animals

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The objective of the present study was to investigate the association among the largest follicle (LF), preovulatory estradiol (E2), and predominant vaginal epithelial cell at the completion of hormonal ovarian stimulation for fixed‐time artificial insemination (FTAI) in goats. Thirty‐seven crossbred Boer does received gonadotropin‐releasing hormone (GnRH) and intravaginal progesterone (P4)‐releasing devices (day 0). On day 5, P4 devices were removed and does received prostaglandin F2α and equine chorionic gonadotrophin. On day 7, does received GnRH, and FTAI was undertaken. On day 7, does were divided into three groups, i.e. small‐sized (3–3.9 mm; n = 5), medium‐sized (4–4.9 mm; n = 8), and large‐sized (≥5 mm; n = 24) according to the diameter of the ovarian LF; follicular characteristics (number and diameter) were identified, and blood samples and vaginal smears were collected. The average diameters of total antral follicles and LF and the percentage of superficial cell were greatest in large‐sized LF does (p < .01). The average diameters of total antral follicle (r = .68) and LF (r = .71), number of preovulatory follicle (r = .58), and plasma E2 concentrations (r = .61) were positively correlated with the percentage of superficial cells (p < .01). The likelihood of a pregnancy outcome after the FTAI increased by 13.71 times in does with a greater average diameter of antral follicle, 14.18 times with emergence of a large preovulatory follicle, and 36.83 times with a higher percentage of vaginal superficial cells (p < .01). It was concluded that there is a relationship between the cell types of the vaginal epithelium, the diameters of the largest ovarian follicles, and the concentration of E2 in goats subjected to FTAI protocols.

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The Effect of Endometrial Thickness on The Day of Human Chorionic Gonadotropin Injection on Reproductive Outcome in Clomiphene Citrate and Intrauterine Insemination Cycles

Aksan,

Dilbaz,

Erturun

et al. 2024

Preprint

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Backround: To evaluate the effect of endometrial thickness (EMT) on the day of Human Chorionic Gonadtropin(hCG) injection on reproductive outcome in clomiphene citrate and intrauterine insemination cycles (CC + IUI). Methods Overall 640 cycles in couples with unexplained infertility or WHO Category 2 normogonadotropic anovulatory women and met the inclusion criteria were analyzed retrospectively. Our study was approved by Ministry of Health, Health Sciences University Etlik Zübeyde Hanim Women’s Institutional Board (30/12/2020-90057706-799) who applied to Reproductive Endocrinology Department of a tertiary center between February 2019 and February 2020 and received ovulation induction with CC + IUI. The demographic characteristics and EMT at the hCG injection day were compared in the group with a clinical pregnancy with those who failed to achieve pregnancy. Results Out of the evaluated 640 cycles, 92 cases had a high β-hCG (14.4%) and 80 (12.5%) resulted in a clinical pregnancy. While 23 (23/640, 3.6%) of the cases with clinical pregnancy experienced spontaneous abortion, 52 (8.1%) resulted in live birth. Maternal age, duration of infertility and clomiphene citrate dosage were found to have an impact on the clinical pregnancy and live birth ratio. The cut-off value for endometrial thickness is 8.45 mm (sensitivity 49.4%, specificity 55.3%) for clinical pregnancy. The incidence of biochemical pregnancy was less while the incidence of clinical pregnancy (p = 0.010) and live birth (p = 0.002) was high in cases with an EMT > 8–9 mm on the day of β-HCG injection Conclusion Higher pregnancy rates have been reported at certain EMT values. However, cycle success can be predicted not only by EMT but also by considering other factors such as female age, infertility duration, and endometrial pattern.

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Influence of clomiphene citrate on induced ovarian hyperstimulation and subsequent fertility in Damascus goats

Cited by 4 publications

References 36 publications

Blood Constituents, Antioxidant Activities and Hormonal Profile in She-camels (Camelus dormedarius) during different Physiological Statuses in the North Western Coast of Egypt

Blood Constituents, Antioxidant Activities and Hormonal Profile in She-camels (Camelus dormedarius) during different Physiological Statuses in the North Western Coast of Egypt

Associations among the largest follicle, preovulatory estradiol concentrations, and predominant vaginal epithelial cells at the completion of hormonal ovarian stimulation for fixed‐time artificial insemination in goats

The Effect of Endometrial Thickness on The Day of Human Chorionic Gonadotropin Injection on Reproductive Outcome in Clomiphene Citrate and Intrauterine Insemination Cycles

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