Influence of citric acid on the physical and biomineralization ability of freeze/thaw poly(vinyl alcohol) hydrogel

Wahid, Mohamad Nizam Abdul; Razak, Saiful Izwan Abd; Kadir, Mohammed Rafiq Abdul; Hassan, Rohayanti; Nayan, Nadirul Hasraf Mat; Amin, Khairul Anuar Mat

doi:10.1177/0885328218771195

Cited by 12 publications

(5 citation statements)

References 27 publications

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“…The broad absorption peak in the wavenumber range of 3275–3300 cm –1 was observed in all the samples, which can correspond to inter/intramolecular hydrogen bond stretching. , The width of the O–H stretching decreased with a corresponding decrease in the PVA concentration in hydrogels (Figure a). An absorption peak near the 1141 cm –1 wavenumber is attributed to the C–C stretching vibration as well as a characteristic of PVA crystallinity. , The presence of the peak at 1141 cm –1 in PVA/SPI hydrogels indicates the crystalline domain of PVA in hydrogels. The individual peaks at 1087, 1326, 1417, and 2944 cm –1 correspond to the C–O stretching vibration, C–C stretching, C–H bond, and C–H stretching, respectively.…”

Section: Resultsmentioning

confidence: 99%

Freeze–Thaw-Induced Physically Cross-linked Superabsorbent Polyvinyl Alcohol/Soy Protein Isolate Hydrogels for Skin Wound Dressing: In Vitro and In Vivo Characterization

Varshney

Sahi

Poddar

et al. 2022

ACS Appl. Mater. Interfaces

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In this work, polyvinyl alcohol (PVA)-and soy protein isolate (SPI)-based scaffolds were prepared by physical cross-linking using the freeze−thaw method. The PVA/SPI ratio was varied to examine the individual effects of the two constituents. The physicochemical properties of the fabricated scaffolds were analyzed through Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry. The SPI concentration significantly affected the properties of scaffolds, such as the extent of gelation (%), pore size, porosity, degradation, swelling, and surface wettability. The in vitro degradation of fabricated hydrogels was evaluated in phosphatebuffered saline and lysozyme solution for a duration of 14 days. The in vitro compatibility of prepared hydrogels was evaluated by the MTT assay with NIH-3T3 cells (fibroblast). The water vapor transmission rate (WVTR) assays showed that all hydrogels possessed WVTR values in the range of 2000−2500 g m −2 day −1 , which is generally recommended for ideal wound dressing. Overall, the obtained results reveal that the fabricated scaffolds have excellent biocompatibility, mechanical strength, porosity, stability, and degradation rate and thus carry enormous potential for tissue engineering applications. Furthermore, a full-thickness wound healing study performed in rats supported them as a promising wound dressing material.

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Section: Resultsmentioning

confidence: 99%

Freeze–Thaw-Induced Physically Cross-linked Superabsorbent Polyvinyl Alcohol/Soy Protein Isolate Hydrogels for Skin Wound Dressing: In Vitro and In Vivo Characterization

Varshney

Sahi

Poddar

et al. 2022

ACS Appl. Mater. Interfaces

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“…Although no significant difference in contact angles was observed between the PAA and TF groups, significant differences were observed when comparing these two groups to the PVA and IDN groups. According to previous studies, 44,45 it was suggested that the presence of polar hydroxyl and carboxylic groups would increase the surface wettability, whereas the presence of crosslinking agents in the PAA may lead to the changes in the surface morphology causing the increase in the contact angle.…”

Section: Resultsmentioning

confidence: 97%

Polyvinyl alcohol-poly acrylic acid bilayer oral drug delivery systems: A comparison between thin films and inverse double network bilayers

et al. 2019

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Polymer network structures in the design of bilayer hydrogels for oral drug delivery systems contribute to the mechanical stability as well as the stimulus responsive drug release. We report a strategy to improve the stability of polyelectrolyte layer interfaces in bilayer hydrogels by employing concepts from tough interpenetrating hydrogel network design. Polyvinyl alcohol as the neutral substrate and Polyacrylic acid as the pH-sensitive layer were used to prepare bilayers capable of pH-sensitive bending behavior, and inverse double network structures were compared to conventional thin film coated bilayers in this study. The morphology of the bilayers observed after exposure to stimulus revealed that the polyacrylic acid layer was fragmented in conventional thin films. The delamination of the coating also had an adverse impact on bending behavior. Additionally, bilayers with inverse double network structure had a better pH-sensitive swelling behavior which was lacking in regular thin films. Controllable, pH-specific drug release behavior was a direct benefit of using the inverse double network structure, and was demonstrated by controlled vancomycin release under different pHs chosen to simulate the physiological milieu of exposure corresponding to hydrogel passage along the gastrointestinal tract. Additionally, the inverse double networks showed improved mucoadhesive properties and mechanical stability compared to the thin film bilayers. The use of inverse double network structured hydrogels has many potential applications in improving bilayer hydrogel stability; specifically, for drug delivery systems, designing hydrogel origamis, and to prepare soft material actuators.

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“…The water contact angle (WCA) was used to measure the hydrophilicity of materials by capturing the image ( Figure 8 ) [ 49 ]. As shown in the WCA values, all samples, except PIP-N3, had a WCA less than 90°, indicating their hydrophilic nature.…”

Section: Resultsmentioning

confidence: 99%

PVA/Inulin-Based Sustainable Films Reinforced with Pickering Emulsion of Niaouli Essential Oil for Potential Wound Healing Applications

et al. 2023

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In this study, sustainable water-based films were produced via the solvent-casting method. Petroleum-free-based polyvinyl alcohol (PVA) and carbohydrate-based inulin (INL) were used as matrices. Vegetable-waste pumpkin powder was used in the study because of its sustainability and antibacterial properties. Pickering emulsions were prepared using β-cyclodextrin. The influence of the different ratios of the β-cyclodextrin/niaouli essential oil (β-CD/NEO) inclusion complex (such as 1:1, 1:3, and 1:5) on the morphological (SEM), thermal (TGA), physical (FT-IR), wettability (contact angle), and mechanical (tensile test) characteristics of PVA/inulin films were investigated. Moreover, the antibacterial activities against the Gram (−) (Escherichia coli and Pseudomonas aeruginosa) and Gram (+) (Staphylococcus aureus) bacteria of the obtained films were studied. From the morphological analysis, good emulsion stability and porosity were obtained in the Pickering films with the highest oil content, while instability was observed in the Pickering films with the lowest concentration of oil content. Thermal and spectroscopic analysis indicated there was no significant difference between the Pickering emulsion films and neat films. With the addition of Pickering emulsions, the tensile stress values decreased from 7.3 ± 1.9 MPa to 3.3 ± 0.2. According to the antibacterial efficiency results, films containing pumpkin powder and Pickering emulsion films containing both pumpkin powder and a ratio of 1:1 (β-CD/NEO) did not have an antibacterial effect, while Pickering emulsion films with a ratio of (β-CD/NEO) 1:3 and 1:5 showed an antibacterial effect against Escherichia coli, with a zone diameter of 12 cm and 17 cm, respectively. Among the samples, the films with ratio of (β-CD/NEO) 1:5 had the highest antioxidant capacity, as assessed by DPPH radical scavenging at 12 h intervals. Further, none of the samples showed any cytotoxic effects the according to LDH and WST-1 cytotoxicity analysis for the NIH3T3 cell line. Ultimately, it is expected that these films are completely bio-based and may be potential candidates for use in wound healing applications.

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Influence of citric acid on the physical and biomineralization ability of freeze/thaw poly(vinyl alcohol) hydrogel

Cited by 12 publications

References 27 publications

Freeze–Thaw-Induced Physically Cross-linked Superabsorbent Polyvinyl Alcohol/Soy Protein Isolate Hydrogels for Skin Wound Dressing: In Vitro and In Vivo Characterization

Freeze–Thaw-Induced Physically Cross-linked Superabsorbent Polyvinyl Alcohol/Soy Protein Isolate Hydrogels for Skin Wound Dressing: In Vitro and In Vivo Characterization

Polyvinyl alcohol-poly acrylic acid bilayer oral drug delivery systems: A comparison between thin films and inverse double network bilayers

PVA/Inulin-Based Sustainable Films Reinforced with Pickering Emulsion of Niaouli Essential Oil for Potential Wound Healing Applications

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