Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis

Eder, Andreas B.; Koegl, Elke; Duvillard, Serge P. von; Sinzinger, H.; Berent, Robert

doi:10.1016/j.archoralbio.2012.05.004

Cited by 10 publications

(10 citation statements)

References 49 publications

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“…When bacteria are eliminated by RCT, the active inflammatory lesion gradually reduces in size, usually accompanied by bone regeneration. 22 , 23 At the same time, the inflammation is always associated with the generation of ROS at the cellular level as well as in biofluids. A difference between local inflammation and OxS in tissues (the endodontium, connective tissue) and systemic OxS in saliva can be observed.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested 23 that systemically generated 8-EPI in saliva could contribute to periapical OxS, as well as bone destruction and pain ( Figure 3 , path IV). Therefore, the generation of 8-EPI due to the chronic AP in saliva and OxS at the level of the spinal cord can result in positive feedback by irritating the primary afferents of the pulp.…”

Section: Discussionmentioning

confidence: 99%

“…IV: systemically generated 8-isoprostanes could contribute to the periapical OxS as well as bone destruction and pain. 23 …”

Section: Figurementioning

confidence: 99%

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Oxidative stress in patients with endodontic pathologies

Vengerfeldt

Mändar

Saag

et al. 2017

JPR

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BackgroundApical periodontitis (AP) is an inflammatory disease affecting periradicular tissues. It is a widespread condition but its etiopathogenetic mechanisms have not been completely elucidated and the current treatment options are not always successful.PurposeTo compare oxidative stress (OxS) levels in the saliva and the endodontium (root canal [RC] contents) in patients with different endodontic pathologies and in endodontically healthy subjects.Patients and methodsThe study group of this comparison study included 22 subjects with primary chronic apical periodontitis (pCAP), 26 with posttreatment or secondary chronic apical periodontitis (sCAP), eight with acute periapical abscess, 13 with irreversible pulpitis, and 17 healthy controls. Resting saliva samples were collected before clinical treatment. Pulp samples (remnants of the pulp, tooth tissue, and/or previous root filling material) were collected under strict aseptic conditions using the Hedström file. The samples were frozen to −80°C until analysis. OxS markers (myeloperoxidase [MPO], oxidative stress index [OSI], 8-isoprostanes [8-EPI]) were detected in the saliva and the endodontium.ResultsThe highest MPO and 8-EPI levels were seen in pCAP and pulpitis, while the highest levels of OSI were seen in pCAP and abscess patients, as well as the saliva of sCAP patients. Controls showed the lowest OxS levels in both RC contents and saliva. Significant positive correlations between OxS markers, periapical index, and pain were revealed. Patients with pain had significantly higher OxS levels in both the endodontium (MPO median 27.9 vs 72.6 ng/mg protein, p=0.004; OSI 6.0 vs 10.4, p<0.001; 8-EPI 50.0 vs 75.0 pg/mL, p<0.001) and saliva (MPO 34.2 vs 117.5 ng/mg protein, p<0.001; 8-EPI 50.0 vs 112.8 pg/mL, p<0.001) compared to pain-free subjects.ConclusionOxS is an important pathomechanism in endodontic pathologies that is evident at both the local (RC contents) and systemic (saliva) level. OxS is significantly associated with dental pain and bone destruction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Oxidative stress in patients with endodontic pathologies

Vengerfeldt

Mändar

Saag

et al. 2017

JPR

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“…Results demonstrate that in smokers with granuloma due to AP, the products of lipid peroxidation as 8‐iso‐PGF(2α) and products of the LOX‐pathway were increased at the expense of cyclooxygenase products (Eder et al . ). Any one of these pathophysiologic pathways can potentially affect the health of the tooth pulp and periradicular bone, resulting in a higher frequency of radiographic PLs in smokers than in nonsmokers (López‐López et al .…”

Section: Association Between Endodontics and Smoking Habitsmentioning

confidence: 97%

“…In periapical granulomas removed from 46 patients, the endogenous synthesis of eicosanoids and isoprostanes, the conversion rate of (14)C labelled arachidonic acid and lipoxygenases (LOX) products was analysed. Results demonstrate that in smokers with granuloma due to AP, the products of lipid peroxidation as 8-iso-PGF(2a) and products of the LOX-pathway were increased at the expense of cyclooxygenase products (Eder et al 2012). Any one of these pathophysiologic pathways can potentially affect the health of the tooth pulp and periradicular bone, resulting in a higher frequency of radiographic PLs in smokers than in nonsmokers (L opez-L opez et al 2012b).…”

Section: Biological Mechanisms Linking Periapical Status and Smokingmentioning

confidence: 99%

Endodontic medicine: connections between apical periodontitis and systemic diseases

2015

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The prevalence of apical periodontitis (AP) in Europe has been reported to affect 61% of individuals and 14% of teeth, and increase with age. Likewise, the prevalence of root canal treatment (RCT) in Europe is estimated to be around 30-50% of individuals and 2-9% of teeth with radiographic evidence of chronic persistent AP in 30-65% of root filled teeth (RFT). AP is not only a local phenomenon and for some time the medical and dental scientific community have analysed the possible connection between apical periodontits and systemic health. Endodontic medicine has developed, with increasing numbers of reports describing the association between periapical inflammation and systemic diseases. The results of studies carried out both in animal models and humans are not conclusive, but suggest an association between endodontic variables, that is AP and RCT, and diabetes mellitus (DM), tobacco smoking, coronary heart disease and other systemic diseases. Several studies have reported a higher prevalence of periapical lesions, delayed periapical repair, greater size of osteolityc lesions, greater likelihood of asymptomatic infections and poorer prognosis for RFT in diabetic patients. On the other hand, recent studies have found that a poorer periapical status correlates with higher HbA1c levels and poor glycaemic control in type 2 diabetic patients. However, there is no scientific evidence supporting a causal effect of periapical inflammation on diabetes metabolic control. The possible association between smoking habits and endodontic infection has also been investigated, with controversial results. The aim of this paper was to review the literature on the association between endodontic variables and systemic health (especially DM and smoking habits).

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Targeted analysis of omega‐6‐derived eicosanoids in human serum by SPE‐LC‐MS/MS for evaluation of coronary artery disease

et al. 2013

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A targeted approach has been applied to quantitative analysis of eicosanoids derived from omega‐6 fatty acids in serum from individuals diagnosed with coronary artery disease (CAD). The target metabolites were series‐2 prostaglandins, thromboxane B2, hydroxy‐eicosatetraenoic acids, and hydroxyoctadecadienoic acids. The method was based on SPE‐LC‐MS/MS in selected reaction monitoring mode for highly selective and sensitive determination of the target eicosanoids. The combination of SPE and LC‐MS/MS involved the benefits from both direct analysis of serum without a step for protein precipitation and fully automation of the analysis. The method allowed comparison of omega‐6‐derived eicosanoids in serum from patients diagnosed with CAD and from control individuals. The effect of treatment with aspirin on the profile of the target compounds was evaluated through its incidence on the different pathways. Finally, the serum levels of the target metabolites in patients diagnosed with CAD were also statistically examined according to the severity of the coronary lesion stratified as stable angina, non‐ST‐elevation acute coronary syndrome, and acute myocardial infarction.

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Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis

Cited by 10 publications

References 49 publications

Oxidative stress in patients with endodontic pathologies

Oxidative stress in patients with endodontic pathologies

Endodontic medicine: connections between apical periodontitis and systemic diseases

Targeted analysis of omega‐6‐derived eicosanoids in human serum by SPE‐LC‐MS/MS for evaluation of coronary artery disease

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