Influence of Cigarette Smoke on Guinea Pigs

Environmentally induced changes in immunological function: acute and chronic effects of inhalation of tobacco smoke and other atmospheric contaminants in man and experimental animals.

“…The immediate effects of exposure to TS (43,45,86,88), 03 (12,20,46), Pb (5), and probably NO2 (31) are to decrease the viability of the pulmonary alveolar macrophage (PAM) population. Longer exposure periods usually result in an increased population of the PAMs in the lung (45,86,89), accompanied in some species by increased numbers of polymorphonuclear leukocytes (27,89). An exception to this rule is Pb exposure (or exhaust fumes containing lead sesquioxide); long-term exposure to these agents depletes the PAM population in the lung (4,5).…”

Quantitative comparisons of the pulmonary toxicity of tobacco and NSM smoke

“…It has been shown that acute exposure to tobacco smoke causes an increase in the activity of acid phosphatase and N-acetyl p-glucuronidase in macrophages (Barry, 1972), although the actual numbers of these cells drops after 1 day's exposure (Rylander, 1973). Longer exposure recruits polymorphonuclear leucocytes to the airways (Flint et al, 1971;Kilburn et al, 1975) and causes an increase in the number of pigmented alveolar macrophages (Dontenwill et al, 1973). Tobacco smoke has also been shown to induce enzymes such as aryl hydrocarbon hydroxylase (AHH) in both whole lung (Holt and Keast, 1973) and in alveolar macrophages (Cantrell et al, 1973).…”