Influence of chrysin on hepatic marker enzymes and lipid profile against d-galactosamine-induced hepatotoxicity rats

Pushpavalli, Ganesan; Veeramani, Chinnadurai; Pugalendi, Kodukkur Viswanathan

doi:10.1016/j.fct.2010.03.040

Cited by 52 publications

(34 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The observed increase in cholesterol level might be due to the inability of the diseased liver to remove cholesterol from circulation. TGL accumulation in plasma of d-GalN administered rats might be from an imbalance between the rate of synthesis and the rate of release of TGL by the parenchymal cells into the systemic circulation (Pushpavalli et al, 2010). An increase in TB and ALP reflects the pathological alteration in biliary flow (Ravikumar et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and antioxidant activity ofLeucas asperaagainst d-galactosamine induced liver damage in rats

Banu¹,

Bhaskar²,

Balasekar³

2012

Pharmaceutical Biology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and antioxidant activity ofLeucas asperaagainst d-galactosamine induced liver damage in rats

Banu¹,

Bhaskar²,

Balasekar³

2012

Pharmaceutical Biology

View full text Add to dashboard Cite

“…The exact mechanisms of action of isotretinoin on increasing cholesterol and triglyceride are still unknown. It is possible that isotretinoin interacts with some essential groups in the active site of the important proteins or enzymes at lipid metabolism such as HMG (hydroxyl metyl glutaryl) redutase, a key regulatory enzyme that plays an important role in cholesterol metabolism (Lamon-Fava et al, 2009;Pushpavalli et al, 2010). However, the exact mechanisms of isotretinoin action on increasing GGT activity are still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Also, recent studies have suggested that serum GGT can also be considered a marker of oxidative stress (Ceyssens et al, 2004). Thus, agents such as some drugs, oxidative stress and inflammation that interfere with lipid metabolism may increase the susceptibility to atherosclerosis and are the subjects of widespread investigations (Lamon-Fava et al, 2009;Pushpavalli et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Ahmadv¹

2011

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

The aim of the present study was the evaluation of serum level of lipids and gamma glutamyl transpeptidase (GGT) activities in patients with acne vulgaris undergoing isotretinoin treatment. Fortyfour patients, with severe acne or moderate acne (age mean 23 6±6.0 year) who were resistant to conventional treatment were supplemented with 0.5 mg/kg/day of oral isotretinoin for 120 days. This study revealed a significant increase in serum level of cholesterol, triglyceride and GGT activity. The findings of this work showed a number of negative effects of isotretinoin on disturbances in lipid profile and antioxidant status, in acne patients. Therefore, to control abnormalities in lipid profiles and oxidative stress, we recommend further studies to use antioxidant such as vitamin E supplementation in patients using isotertinoin.

show abstract

“…More recently Jegadeesh et al stated that mushroom has greater significance in prevention of hyperlipidemia and cardiovascular disease [14]. On the same line, chrysin (5,7-dihydroxyflavone) is a natural flavonoids present in many plant extracts, honey and propolis [15,16]. Chrysin has anti-inflammatory and antioxidant properties, and is used as a dietary supplement [17].…”

Section: Introductionmentioning

confidence: 99%

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

Ismail¹,

Soliman²,

Nassan³

et al. 2015

JFNR

View full text Add to dashboard Cite

Hypercholesterolemia and hypertriglyceridemia are major risk factors that accelerate the incidence of atherosclerosis and coronary artery diseases. Therefore, the present study was conducted to evaluate the hypolipidemic effect of widely known traditional medicinal herbs and omega-3 FA in experimental hypercholesterolemia induced by Triton WR-1339. Experimental hypercholesterolemic rats were administered mushroom, chrysin, curcumin and omega-3 for 2 weeks. Hypercholesterolemic rats showed an increase in serum levels of lipid profiles and hepatic enzymes. Hypercholesterolemic rats showed an increase in malondialdehyde (MDA) levels and a decrease in both serum levels and mRNA expression of catalase, superoxide dismutase (SOD) and glutathione reducatse. Moreover, hypercholesterolemic rats showed hepatic down regulation in the expression of genes related to fatty acids oxidation such as acyl CoA oxidase (ACO) and synthetase (ACS), together with carnityl palmityl transferase-1 (CPT-1) and peroxisome proliferator activator receptor-α (PPAR-α). Administration of mushroom, chrysin, curcumin and omega-3 to hypercholesterolemic rats for 2 weeks up-regulated significantly the down regulated genes. In contrast, expression of genes related to fatty acids biosynthesis and cholesterol metabolism were increased in hypercholesterolemic rats compared to control group. Herbal medications and omega-3 administration down regulated genes of fatty acids biosynthesis and cholesterol metabolism to normal expression. At cellular levels, hyperlipidemia induced fatty droplets accumulation, necrosis and presence of apoptotic hepatocytes together with leukocytic infiltration in necrotic area that are ameliorated and normalized after administration of herbs and omega-3. In conclusion, the current findings indicated that flavonoids (mushroom, chrysin, curcumin) and omega-3 possess antihypercholesterolemic effects at biochemical, molecular and histopathological levels and are useful in treatment of hypercholesterolemia with lower side effects compared with synthetic hypolipidemic drugs.

show abstract

Influence of chrysin on hepatic marker enzymes and lipid profile against d-galactosamine-induced hepatotoxicity rats

Cited by 52 publications

References 35 publications

Hepatoprotective and antioxidant activity ofLeucas asperaagainst d-galactosamine induced liver damage in rats

Hepatoprotective and antioxidant activity ofLeucas asperaagainst d-galactosamine induced liver damage in rats

Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Antihypercholesterolemic Effects of Mushroom, Chrysin, Curcumin and Omega-3 in Experimental Hypercholesterolemic Rats

Contact Info

Product

Resources

About