Influence of Chronic Hepatitis B and C Infections on Anemia in Hemodialysis Patients

Fouad, Mohamed M.; Ismail, Mabrouk I.; Mahmoud, Amira A.; Fathy, Hassan; Zidan, Amal; Mostafa, Ezzat

doi:10.18650/2378-542x.21001

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the current study showed a significant decreased in RBCs counts, Hb, Hct, MCH, and MCHC, and increase in MCV in the hemodialysis patients compared with the healthy individuals. These results run parallel with those obtained by the previous studies [27][28][29][30][31]. Olasunkanmi et al [26] and Singh and Bhatta [30] reported that hemoglobin concentration, Hct value, and RBCs count were significantly changes in chronic kidney disease patients compared with the healthy individuals.…”

Section: Discussionsupporting

confidence: 89%

Prevalence of Anemia and Variations of Hematological Parameters among Anemic Hemodialysis Patients in the Tripoli Region

Azab¹,

Alshoukry²

2023

GJCD

View full text Add to dashboard Cite

Background: Prolonged decline in the ability of the kidney to regulate acid-base balance, eliminate waste products, and manage water homeostasis and entered chronic phase, toxic metabolic accumulates and erythropoietin secretion by the kidney is decreasing and causes hematological changes including decrease of HCT, MCV, RBCs and platelet counts. Hemodialysis became a practical treatment for kidney failure and is the most common method used to treat advanced and permanent kidney failure. Anemia is one of the most common complications in hemodialysis patients. Objectives: The study aimed to evaluate the prevalence of anemia among hemodialysis patients and investigate the variations of hematological parameters among anemic hemodialysis patients in the Tripoli region. Materials and Methods: The present study was conducted on 250 renal failure patients, attending Tripoli Center for dialysis and 100 normal healthy subjects. The study Ethical Committee of the medical centers and the Libyan Academy of graduate studies reviewed and approved the study design and patient consent statements were taken from each patient. Information's about the patients were recorded in a questionnaire. A blood sample of 5 ml was drawn by venous puncture from each normal healthy individual and hemodialysis patient. 2.5 ml of the blood sample was collected in K-EDTA tubes for the hematological examinations and another 2.5 ml of the blood sample was collected in a plain tubes for biochemical tests (serum urea, creatinine, and uric acid concentrations). The hematological parameters (RBCs count, Hb, HCT, MCV, MCH, MCHC, WBCs count, differential count of WBCs, and Platelets count) were determined using an automated hematology analyzer Sysmex (K-4500) machine. The data were compared using GraphPad Prism version.9. The statistical significance of differences between groups was evaluated with the independent t-test. A P-value of <0.05 was considered significant for all statistical tests. Results: The results showed that the prevalence of anemia among hemodialysis patients was 89.8%. The degrees of anemia were 17% severe, 71.66% moderate, and 11.34% mild anemia. The types of anemia were 13.36% microcytic hypochromic, 82.59% normocytic hypochromic, and 4.05% macrocytic hypochromic anemia. RBCs, WBCs & platelets counts, Hct, MCHC, and Lymphocytes % showed a significant (P<0.01) decrease, and MCV was a significant (P<0.01) increase in the anemic hemodialysis patients compared with the healthy individuals. But, a significant (P<0.05) decrease in MCH was observed in the anemic hemodialysis patients when compared with the healthy individuals. A significant correlation was observed between RBCs and their indices with most of the hematological parameters. A significant (P<0.01) negative correlation was observed between serum urea with Hb, and RBCs count and Hct. While, a significant (P<0.01) positive correlation was recorded between uric acid with platelets count. A significant (P<0.05) positive correlation was observed between gender with platelets count, wh...

show abstract

Section: Discussionsupporting

confidence: 89%

Prevalence of Anemia and Variations of Hematological Parameters among Anemic Hemodialysis Patients in the Tripoli Region

Azab¹,

Alshoukry²

2023

GJCD

View full text Add to dashboard Cite

show abstract

Assessment of the impact of anemia on hematological parameters among hemodialysis patients with chronic kidney disease

Humudat

2023

View full text Add to dashboard Cite

Anemia is a common consequence of chronic kidney disease (CKD) that is linked to a decrease in patients' quality of life, a rise in morbidity and mortality, and an acceleration in CKD progression. This study aimed to investigate the hematological profile of chronic renal patients undergoing hemodialysis and to correlate the same with anemia. Fifty (54% males and 46% females) with ages ranging from 18-76 years of patients with CKD and on regular maintenance hemodialysis not less than three months at the Iraqi center for dialysis in Baghdad teaching hospital, and 30 healthy adults were recruited into the study. Hemoglobin concentration, red cell count, white blood cell count, platelet count, ESR, CRP and HCV were assessed for the subjects and controls. Results were analyzed using a t-test independent, and the data were retrieved from the laboratory information system in the hospital. Red blood cell count was reduced in nearly all (96%) of the study patients, while ESR was elevated in (98%) and CRP was elevated in (95%). All patients suffered anemia in HD patients. Most of the patients' WBCs and platelet counts were normal. Anti-HCV antibodies were positive in 15 (30%) of these patients, with non-significant differences in both genders. The study concludes that anemia is a significant comorbidity in hemodialysis patients, with several factors contributing to it, and thorough workup and successful treatment of anemia are essential in this group of patients. Keywords: Anemia; Hematological profile; Hemodialysis; Hepatitis; chronic kidney disease

show abstract

Influence of Chronic Hepatitis B and C Infections on Anemia in Hemodialysis Patients

Cited by 2 publications

References 0 publications

Prevalence of Anemia and Variations of Hematological Parameters among Anemic Hemodialysis Patients in the Tripoli Region

Prevalence of Anemia and Variations of Hematological Parameters among Anemic Hemodialysis Patients in the Tripoli Region

Assessment of the impact of anemia on hematological parameters among hemodialysis patients with chronic kidney disease

Contact Info

Product

Resources

About