Influence of chronic endometritis on women`s reproductive health: current view

Abstract

Chronic inflammatory process in endometrium is an obvious factor of infertility and recurrent pregnancy loss. But uncertainty of its etiology in most of the clinical cases results in complications of diagnostic process of the disease despite the broad spectrum of diagnostic techniques. Shift of the focus from specific infectious agents towards opportunistic pathogens also leads to several complications in interpretation of bacteriological examination results. Moreover, the role of viruses as ethiological factor of chronic endometritis is still not well established. At the same time the capability of invasive diagnostic techniques is always discussed by the clinicians because of additional risks from intervention into uterine cavity. From this point of view treatment of chronic endometritis (CE) and pregravid preparation of women involved in in vitro fertilization algorithm with such pathology requires comprehensive analysis. Routine antibiotic administration, principles of choice of these medications and effectiveness of other therapeutical approaches, for example, physiotherapy techniques, are still controversial. This article highlights modern ideas about chronic endometritis: ethiological factors of the disorder, coincidence with infertility and reproductive failure, diagnostic methods, treatment and pregravid preparation of women with the disease and ways of optimization of patient management for preserving their reproductive potential. Key words: chronic endometritis, infertility, in vitro fertilization, antibiotic therapy.