Influence of chronic dosing on theophylline clearance.

Folláth, Ferenc

doi:10.1111/j.1365-2125.1985.tb02703.x

Brit J Clinical Pharma

1985

DOI: 10.1111/j.1365-2125.1985.tb02703.x

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Influence of chronic dosing on theophylline clearance.

Ferenc Folláth¹

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1985

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“…Influence of chronic dosing on theophylline clearance Vozeh & Follath (1985) have given two reasons in criticizing our exclusion of concentration dependence as a possible mechanism for the difference in oral clearances of theophylline (Efthimiou et al, 1984).…”

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confidence: 99%

“…The size of the loading dose determines the plasma drug concentration at the end of the 20 min loading infusion and, as Vozeh & Follath (1985) point out, for some time thereafter. Thus, Voieh & Follath (1985) argue that basing the intravenous loading dose on the oral clearance value will bias the apparent intravenous clearance value obtained towards the oral clearance value.…”

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Influence of chronic dosing on theophylline clearance.

Morgan¹,

Raymond²,

McLean³

1985

Brit J Clinical Pharma

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mentioning

confidence: 99%

mentioning

confidence: 99%

Influence of chronic dosing on theophylline clearance.

Morgan¹,

Raymond²,

McLean³

1985

Brit J Clinical Pharma

View full text Add to dashboard Cite

Influence of chronic dosing on theophylline clearance.

Efthimiou¹,

Morgan²,

Ioannides‐Demos³

et al. 1984

Brit J Clinical Pharma

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Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/‐ 6.48 ml/min (mean +/‐ s.e. mean, n = 10) to 48.0 +/‐ 6.4 ml/min. Steady‐state intravenous clearance decreased by 26 +/‐ 2% from 55.1 +/‐ 7.7 ml/min to 41.0 +/‐ 5.96 ml/min (mean +/‐ s.e. mean, n = 6; P less than 0.001) at constant steady‐state intravenous test concentrations (mean 15.0 +/‐ 1.6 micrograms/ml after chronic oral dosing), excluding significant concentration dependence. Extrapolation of acute clearance findings to maintenance requirement may not be valid even in the same individual, with theophylline therapy requiring on‐going review beyond acute stabilisation.

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Influence of chronic dosing on theophylline clearance.

Cited by 2 publications

References 1 publication

Influence of chronic dosing on theophylline clearance.

Influence of chronic dosing on theophylline clearance.

Influence of chronic dosing on theophylline clearance.

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